Sleep and cognition in children with fetal alcohol spectrum disorders (Fasd) and children with autism spectrum disorders (asd)
Sleep and cognition in children with fetal alcohol spectrum disorders (Fasd) and children with autism spectrum disorders (asd)
Children with Fetal Alcohol Spectrum Disorders (FASD) and Autism Spectrum Disorders (ASD) experience significantly higher rates of sleep disturbances than their typically developing peers. However, little is known about the association between sleep and the cognitive phenotype in these clinical populations. Structural damage affecting cortical and subcortical connectivity occurs as a result of prenatal alcohol exposure in children with FASD, whilst it is believed an abundance of short-range connectivity explains the phenotypic manifestations of childhood ASD. These underlying neural structural and connectivity differences manifest as cognitive patterns, with some shared and some unique characteristics between FASD and ASD. This is the first study to examine sleep and its association with cognition in individuals with FASD, and to compare sleep in individuals with FASD and ASD. We assessed children aged 6–12 years with a diagnosis of FASD (n = 29), ASD (n = 21), and Typically Developing (TD) children (n = 46) using actigraphy (CamNTech Actiwatch 8), digit span tests of working memory (Weschler Intelligence Scale), tests of nonverbal mental age (MA; Ravens Standard Progressive Matrices), receptive vocabulary (British Picture Vocabulary Scale), and a choice reaction time (CRT) task. Children with FASD and ASD presented with significantly shorter total sleep duration, lower sleep efficiency, and more nocturnal wakings than their TD peers. Sleep was significantly associated with scores on the cognitive tests in all three groups. Our findings support the growing body of work asserting that sleep is significant to cognitive functioning in these neurodevelopmental conditions; however, more research is needed to determine cause and effect.
Actigraphy, ASD, Autism, Autism spectrum disorder, Cognition, FASD, Fetal alcohol spectrum disorder, Sleep
Mughal, Rabya
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Hill, Catherine M.
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Joyce, Anna
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Dimitriou, Dagmara
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November 2020
Mughal, Rabya
bf81f246-8088-4af3-a379-aa52965d63f7
Hill, Catherine M.
867cd0a0-dabc-4152-b4bf-8e9fbc0edf8d
Joyce, Anna
b0a0c3c1-0792-4d2a-a50b-251cae879884
Dimitriou, Dagmara
3b510b78-4c3d-49d9-8960-84450c33c5c9
Mughal, Rabya, Hill, Catherine M., Joyce, Anna and Dimitriou, Dagmara
(2020)
Sleep and cognition in children with fetal alcohol spectrum disorders (Fasd) and children with autism spectrum disorders (asd).
Brain Sciences, 10 (11), [863].
(doi:10.3390/brainsci10110863).
Abstract
Children with Fetal Alcohol Spectrum Disorders (FASD) and Autism Spectrum Disorders (ASD) experience significantly higher rates of sleep disturbances than their typically developing peers. However, little is known about the association between sleep and the cognitive phenotype in these clinical populations. Structural damage affecting cortical and subcortical connectivity occurs as a result of prenatal alcohol exposure in children with FASD, whilst it is believed an abundance of short-range connectivity explains the phenotypic manifestations of childhood ASD. These underlying neural structural and connectivity differences manifest as cognitive patterns, with some shared and some unique characteristics between FASD and ASD. This is the first study to examine sleep and its association with cognition in individuals with FASD, and to compare sleep in individuals with FASD and ASD. We assessed children aged 6–12 years with a diagnosis of FASD (n = 29), ASD (n = 21), and Typically Developing (TD) children (n = 46) using actigraphy (CamNTech Actiwatch 8), digit span tests of working memory (Weschler Intelligence Scale), tests of nonverbal mental age (MA; Ravens Standard Progressive Matrices), receptive vocabulary (British Picture Vocabulary Scale), and a choice reaction time (CRT) task. Children with FASD and ASD presented with significantly shorter total sleep duration, lower sleep efficiency, and more nocturnal wakings than their TD peers. Sleep was significantly associated with scores on the cognitive tests in all three groups. Our findings support the growing body of work asserting that sleep is significant to cognitive functioning in these neurodevelopmental conditions; however, more research is needed to determine cause and effect.
Text
brainsci-10-00863-v3
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More information
Accepted/In Press date: 9 November 2020
e-pub ahead of print date: 16 November 2020
Published date: November 2020
Keywords:
Actigraphy, ASD, Autism, Autism spectrum disorder, Cognition, FASD, Fetal alcohol spectrum disorder, Sleep
Identifiers
Local EPrints ID: 450184
URI: http://eprints.soton.ac.uk/id/eprint/450184
ISSN: 2076-3425
PURE UUID: 19663ca2-ffe6-47c5-bdb0-84de667ea331
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Date deposited: 15 Jul 2021 16:35
Last modified: 06 Jun 2024 01:37
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Author:
Rabya Mughal
Author:
Anna Joyce
Author:
Dagmara Dimitriou
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