Review: The Nutritional Management of Multiple Sclerosis With Propionate
Review: The Nutritional Management of Multiple Sclerosis With Propionate
Over the last 15 years there has been an accumulation of data supporting the concept of a gut-brain axis whereby dysbiosis of the gut microbiota can impact neurological function. Such dysbiosis has been suggested as a possible environmental exposure triggering multiple sclerosis (MS). Dysbiosis has been consistently shown to result in a reduction in short-chain fatty acid (SCFA) producing bacteria and a reduction in stool and plasma levels of propionate has been shown for MS patients independent of disease stage and in different geographies. A wealth of evidence supports the action of propionate on T-cell activity, resulting in decreased T-helper cell 1 (Th1) and T-helper cell 17 (Th17) numbers/activity and increased regulatory T cell (Treg cell) numbers/activity and an overall anti-inflammatory profile. These different T-cell populations play various roles in the pathophysiology of MS. A recent clinical study in MS patients demonstrated that supplementation of propionate reduces the annual relapse rate and slows disease progression. This review discusses this data and the relevant mechanistic background and discusses whether taming of the overactive immune system in MS is likely to allow easier bacterial and viral infection.
auto-immune, immunity, microbiota, multiple sclerosis, propionate, short chain fatty acid
Tobin, Derek
4e08e45d-a820-4d4d-9e03-efdabbda08f1
Vige, Runar
667c0c76-48c3-47e6-8ab6-c69e7e73b4e9
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
28 July 2021
Tobin, Derek
4e08e45d-a820-4d4d-9e03-efdabbda08f1
Vige, Runar
667c0c76-48c3-47e6-8ab6-c69e7e73b4e9
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Tobin, Derek, Vige, Runar and Calder, Philip
(2021)
Review: The Nutritional Management of Multiple Sclerosis With Propionate.
Frontiers in Immunology, 12, [676016].
(doi:10.3389/fimmu.2021.676016).
Abstract
Over the last 15 years there has been an accumulation of data supporting the concept of a gut-brain axis whereby dysbiosis of the gut microbiota can impact neurological function. Such dysbiosis has been suggested as a possible environmental exposure triggering multiple sclerosis (MS). Dysbiosis has been consistently shown to result in a reduction in short-chain fatty acid (SCFA) producing bacteria and a reduction in stool and plasma levels of propionate has been shown for MS patients independent of disease stage and in different geographies. A wealth of evidence supports the action of propionate on T-cell activity, resulting in decreased T-helper cell 1 (Th1) and T-helper cell 17 (Th17) numbers/activity and increased regulatory T cell (Treg cell) numbers/activity and an overall anti-inflammatory profile. These different T-cell populations play various roles in the pathophysiology of MS. A recent clinical study in MS patients demonstrated that supplementation of propionate reduces the annual relapse rate and slows disease progression. This review discusses this data and the relevant mechanistic background and discusses whether taming of the overactive immune system in MS is likely to allow easier bacterial and viral infection.
Text
676016_Manuscript
- Accepted Manuscript
More information
Accepted/In Press date: 14 July 2021
Published date: 28 July 2021
Additional Information:
Copyright © 2021 Tobin, Vige and Calder.
Keywords:
auto-immune, immunity, microbiota, multiple sclerosis, propionate, short chain fatty acid
Identifiers
Local EPrints ID: 450437
URI: http://eprints.soton.ac.uk/id/eprint/450437
ISSN: 1664-3224
PURE UUID: c951e36b-d7ec-490d-85e0-9cb3683edd53
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Date deposited: 28 Jul 2021 16:31
Last modified: 17 Mar 2024 06:43
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Author:
Derek Tobin
Author:
Runar Vige
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