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CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer

CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer
CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer

We report a rapidly progressive and fatal CD8 T-cell-mediated cerebellitis after ipilimumab (cytotoxic T-lymphocyte-associated protein 4 inhibitor) for small cell lung cancer. Clinical features and histopathology were consistent with an accelerated form of paraneoplastic cerebellar degeneration. A patchy CD8 T-cell infiltrate spatially corresponded to areas of Purkinje cell loss, with occasional CD8 polarisation towards Purkinje cells. CD20-positive B cells were sparse. CD8 T-cell-mediated cerebellitis after immune checkpoint inhibitor treatment may recapitulate the early stages of paraneoplastic cerebellar degeneration.

CD8 T cells, CTLA-4 inhibitor, cerebellitis, immune checkpoint inhibitors, ipilimumab, paraneoplastic cerebellar degeneration
0305-1846
Hardwick, Marc
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Nolan, Luke
76616eba-b3a6-4d74-ad1b-db49dd8ebc01
Nicoll, James
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Jogai, Sanjay
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Arriola, Edurne
d6f5bb26-ab29-47a1-8272-8e49354561c8
Joseph-Pietras, Debora
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Norman, Jeanette
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Ottensmeier, Christian
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Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Hardwick, Marc
bdd1774b-9ec8-42af-a84a-b7a7b2813c35
Nolan, Luke
76616eba-b3a6-4d74-ad1b-db49dd8ebc01
Nicoll, James
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Jogai, Sanjay
18c2f36b-4572-46d5-b17d-a6d2cdaa916c
Arriola, Edurne
d6f5bb26-ab29-47a1-8272-8e49354561c8
Joseph-Pietras, Debora
3002f7ea-3689-40c3-8949-9da8f0753c91
Norman, Jeanette
b4fa0e8e-3b6e-458b-af1e-2f55c651639a
Ottensmeier, Christian
65a7a864-5bbc-4c0c-ba58-9d6a5e7c1197
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b

Hardwick, Marc, Nolan, Luke, Nicoll, James, Jogai, Sanjay, Arriola, Edurne, Joseph-Pietras, Debora, Norman, Jeanette, Ottensmeier, Christian and Galea, Ian (2021) CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer. Neuropathology and Applied Neurobiology. (doi:10.1111/nan.12755).

Record type: Article

Abstract

We report a rapidly progressive and fatal CD8 T-cell-mediated cerebellitis after ipilimumab (cytotoxic T-lymphocyte-associated protein 4 inhibitor) for small cell lung cancer. Clinical features and histopathology were consistent with an accelerated form of paraneoplastic cerebellar degeneration. A patchy CD8 T-cell infiltrate spatially corresponded to areas of Purkinje cell loss, with occasional CD8 polarisation towards Purkinje cells. CD20-positive B cells were sparse. CD8 T-cell-mediated cerebellitis after immune checkpoint inhibitor treatment may recapitulate the early stages of paraneoplastic cerebellar degeneration.

Text
Hardwick et al 2021 - Accepted Manuscript
Available under License Creative Commons Attribution.
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More information

Accepted/In Press date: 15 July 2021
e-pub ahead of print date: 26 July 2021
Keywords: CD8 T cells, CTLA-4 inhibitor, cerebellitis, immune checkpoint inhibitors, ipilimumab, paraneoplastic cerebellar degeneration

Identifiers

Local EPrints ID: 450524
URI: http://eprints.soton.ac.uk/id/eprint/450524
ISSN: 0305-1846
PURE UUID: 335838ee-59f8-4a9d-ab0c-48b5aba4360f
ORCID for James Nicoll: ORCID iD orcid.org/0000-0002-9444-7246
ORCID for Ian Galea: ORCID iD orcid.org/0000-0002-1268-5102

Catalogue record

Date deposited: 03 Aug 2021 16:30
Last modified: 26 Nov 2021 02:47

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Contributors

Author: Marc Hardwick
Author: Luke Nolan
Author: James Nicoll ORCID iD
Author: Sanjay Jogai
Author: Edurne Arriola
Author: Debora Joseph-Pietras
Author: Jeanette Norman
Author: Christian Ottensmeier
Author: Ian Galea ORCID iD

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