CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer
CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer
We report a rapidly progressive and fatal CD8 T-cell-mediated cerebellitis after ipilimumab (cytotoxic T-lymphocyte-associated protein 4 inhibitor) for small cell lung cancer. Clinical features and histopathology were consistent with an accelerated form of paraneoplastic cerebellar degeneration. A patchy CD8 T-cell infiltrate spatially corresponded to areas of Purkinje cell loss, with occasional CD8 polarisation towards Purkinje cells. CD20-positive B cells were sparse. CD8 T-cell-mediated cerebellitis after immune checkpoint inhibitor treatment may recapitulate the early stages of paraneoplastic cerebellar degeneration.
CD8 T cells, CTLA-4 inhibitor, cerebellitis, immune checkpoint inhibitors, ipilimumab, paraneoplastic cerebellar degeneration
Hardwick, Marc
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Nolan, Luke
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Nicoll, James
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Jogai, Sanjay
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Arriola, Edurne
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Joseph-Pietras, Debora
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Norman, Jeanette
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Ottensmeier, Christian
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Galea, Ian
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Hardwick, Marc
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Nolan, Luke
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Nicoll, James
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Jogai, Sanjay
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Arriola, Edurne
d6f5bb26-ab29-47a1-8272-8e49354561c8
Joseph-Pietras, Debora
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Norman, Jeanette
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Ottensmeier, Christian
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Galea, Ian
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Hardwick, Marc, Nolan, Luke, Nicoll, James, Jogai, Sanjay, Arriola, Edurne, Joseph-Pietras, Debora, Norman, Jeanette, Ottensmeier, Christian and Galea, Ian
(2021)
CD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer.
Neuropathology and Applied Neurobiology.
(doi:10.1111/nan.12755).
Abstract
We report a rapidly progressive and fatal CD8 T-cell-mediated cerebellitis after ipilimumab (cytotoxic T-lymphocyte-associated protein 4 inhibitor) for small cell lung cancer. Clinical features and histopathology were consistent with an accelerated form of paraneoplastic cerebellar degeneration. A patchy CD8 T-cell infiltrate spatially corresponded to areas of Purkinje cell loss, with occasional CD8 polarisation towards Purkinje cells. CD20-positive B cells were sparse. CD8 T-cell-mediated cerebellitis after immune checkpoint inhibitor treatment may recapitulate the early stages of paraneoplastic cerebellar degeneration.
Text
Hardwick et al 2021
- Accepted Manuscript
More information
Accepted/In Press date: 15 July 2021
e-pub ahead of print date: 26 July 2021
Keywords:
CD8 T cells, CTLA-4 inhibitor, cerebellitis, immune checkpoint inhibitors, ipilimumab, paraneoplastic cerebellar degeneration
Identifiers
Local EPrints ID: 450524
URI: http://eprints.soton.ac.uk/id/eprint/450524
ISSN: 0305-1846
PURE UUID: 335838ee-59f8-4a9d-ab0c-48b5aba4360f
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Date deposited: 03 Aug 2021 16:30
Last modified: 17 Mar 2024 02:57
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Contributors
Author:
Marc Hardwick
Author:
Luke Nolan
Author:
Sanjay Jogai
Author:
Edurne Arriola
Author:
Debora Joseph-Pietras
Author:
Jeanette Norman
Author:
Christian Ottensmeier
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