Ta, Le Duc Huy, Tay, Carina Jing Xuan, Lay, Christophe, de Sessions, Paola Florez, Tan, Cheryl Pei-Ting, Tay, Michelle Jia-Yu, Lau, Hui Xing, Zulkiffi, Atiqa Binte, Yap, Gaik Chin, Tham, Elizabeth Huiwen, Ho, Eliza Xin Peri, Goh, Anne Eng Neo, Godfrey, Keith, Eriksson, Johan G., Knol, Jan, Gluckman, Peter D., Chong, Yap-Seng, Chan, Jerry Kok Yen, Tan, Kok Hian, Chong, Kok Wee, Goh, Si Hui, Cheng, Zai Ru, Lee, Bee Wah, Shek, Lynette P. and Loo, Evelyn X.L. (2021) Household environmental microbiota influences early-life eczema development. Environmental Microbiology Reports. (doi:10.1111/1462-2920.15684).
Abstract
Exposure to a diverse microbial environment during pregnancy and early postnatal period is important in determining predisposition towards allergy. However, the effect of environmental microbiota exposure on allergy during preconception, pregnancy and postnatal life on development of allergy in the child has not been investigated so far. In the S-PRESTO (Singapore PREconception Study of long Term maternal and child Outcomes) cohort, we collected house dust during all three critical window periods and analysed microbial composition using 16S rRNA gene sequencing. At 6 and 18 months, the child was assessed for eczema by clinicians. In the eczema group, household environmental microbiota was characterized by presence of human-associated bacteria Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium at all time points, suggesting their possible contributions to regulating host immunity and increasing the susceptibility to eczema. In the home environment of the control group, putative protective effect of an environmental microbe Planomicrobium (Planococcaceae family) was observed to be significantly higher than that in the eczema group. Network correlation analysis demonstrated inverse relationships between beneficial Planomicrobium and human associated bacteria (Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium). Exposure to natural environmental microbiota may be beneficial to modulate shed human associated microbiota in an indoor environment.
More information
Identifiers
Catalogue record
Export record
Altmetrics
Contributors
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.