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Household environmental microbiota influences early-life eczema development

Household environmental microbiota influences early-life eczema development
Household environmental microbiota influences early-life eczema development
Exposure to a diverse microbial environment during pregnancy and early postnatal period is important in determining predisposition towards allergy. However, the effect of environmental microbiota exposure on allergy during preconception, pregnancy and postnatal life on development of allergy in the child has not been investigated so far. In the S-PRESTO (Singapore PREconception Study of long Term maternal and child Outcomes) cohort, we collected house dust during all three critical window periods and analysed microbial composition using 16S rRNA gene sequencing. At 6 and 18 months, the child was assessed for eczema by clinicians. In the eczema group, household environmental microbiota was characterized by presence of human-associated bacteria Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium at all time points, suggesting their possible contributions to regulating host immunity and increasing the susceptibility to eczema. In the home environment of the control group, putative protective effect of an environmental microbe Planomicrobium (Planococcaceae family) was observed to be significantly higher than that in the eczema group. Network correlation analysis demonstrated inverse relationships between beneficial Planomicrobium and human associated bacteria (Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium). Exposure to natural environmental microbiota may be beneficial to modulate shed human associated microbiota in an indoor environment.
1758-2229
Ta, Le Duc Huy
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Tay, Carina Jing Xuan
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Lay, Christophe
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de Sessions, Paola Florez
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Tan, Cheryl Pei-Ting
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Lau, Hui Xing
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Yap, Gaik Chin
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Tham, Elizabeth Huiwen
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Godfrey, Keith
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Eriksson, Johan G.
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Knol, Jan
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Gluckman, Peter D.
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Chong, Yap-Seng
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Shek, Lynette P.
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Ta, Le Duc Huy
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Tay, Carina Jing Xuan
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Lay, Christophe
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de Sessions, Paola Florez
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Tan, Cheryl Pei-Ting
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Tay, Michelle Jia-Yu
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Lau, Hui Xing
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Zulkiffi, Atiqa Binte
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Yap, Gaik Chin
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Tham, Elizabeth Huiwen
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Ho, Eliza Xin Peri
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Goh, Anne Eng Neo
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Godfrey, Keith
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Eriksson, Johan G.
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Knol, Jan
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Gluckman, Peter D.
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Chong, Yap-Seng
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Chan, Jerry Kok Yen
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Tan, Kok Hian
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Chong, Kok Wee
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Goh, Si Hui
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Cheng, Zai Ru
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Lee, Bee Wah
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Shek, Lynette P.
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Loo, Evelyn X.L.
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Ta, Le Duc Huy, Tay, Carina Jing Xuan, Lay, Christophe, de Sessions, Paola Florez, Tan, Cheryl Pei-Ting, Tay, Michelle Jia-Yu, Lau, Hui Xing, Zulkiffi, Atiqa Binte, Yap, Gaik Chin, Tham, Elizabeth Huiwen, Ho, Eliza Xin Peri, Goh, Anne Eng Neo, Godfrey, Keith, Eriksson, Johan G., Knol, Jan, Gluckman, Peter D., Chong, Yap-Seng, Chan, Jerry Kok Yen, Tan, Kok Hian, Chong, Kok Wee, Goh, Si Hui, Cheng, Zai Ru, Lee, Bee Wah, Shek, Lynette P. and Loo, Evelyn X.L. (2021) Household environmental microbiota influences early-life eczema development. Environmental Microbiology Reports. (doi:10.1111/1462-2920.15684).

Record type: Article

Abstract

Exposure to a diverse microbial environment during pregnancy and early postnatal period is important in determining predisposition towards allergy. However, the effect of environmental microbiota exposure on allergy during preconception, pregnancy and postnatal life on development of allergy in the child has not been investigated so far. In the S-PRESTO (Singapore PREconception Study of long Term maternal and child Outcomes) cohort, we collected house dust during all three critical window periods and analysed microbial composition using 16S rRNA gene sequencing. At 6 and 18 months, the child was assessed for eczema by clinicians. In the eczema group, household environmental microbiota was characterized by presence of human-associated bacteria Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium at all time points, suggesting their possible contributions to regulating host immunity and increasing the susceptibility to eczema. In the home environment of the control group, putative protective effect of an environmental microbe Planomicrobium (Planococcaceae family) was observed to be significantly higher than that in the eczema group. Network correlation analysis demonstrated inverse relationships between beneficial Planomicrobium and human associated bacteria (Actinomyces, Anaerococcus, Finegoldia, Micrococcus, Prevotella and Propionibacterium). Exposure to natural environmental microbiota may be beneficial to modulate shed human associated microbiota in an indoor environment.

Text
SPRESTO Dust Manuscript revised EMI clean 210621 - Accepted Manuscript
Restricted to Repository staff only until 26 July 2022.
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More information

Accepted/In Press date: 19 July 2021
e-pub ahead of print date: 26 July 2021

Identifiers

Local EPrints ID: 450583
URI: http://eprints.soton.ac.uk/id/eprint/450583
ISSN: 1758-2229
PURE UUID: ac5a9d3f-ad1b-41c2-8ac6-842b7698c26f
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 04 Aug 2021 16:34
Last modified: 15 Oct 2021 01:34

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Contributors

Author: Le Duc Huy Ta
Author: Carina Jing Xuan Tay
Author: Christophe Lay
Author: Paola Florez de Sessions
Author: Cheryl Pei-Ting Tan
Author: Michelle Jia-Yu Tay
Author: Hui Xing Lau
Author: Atiqa Binte Zulkiffi
Author: Gaik Chin Yap
Author: Elizabeth Huiwen Tham
Author: Eliza Xin Peri Ho
Author: Anne Eng Neo Goh
Author: Keith Godfrey ORCID iD
Author: Johan G. Eriksson
Author: Jan Knol
Author: Peter D. Gluckman
Author: Yap-Seng Chong
Author: Jerry Kok Yen Chan
Author: Kok Hian Tan
Author: Kok Wee Chong
Author: Si Hui Goh
Author: Zai Ru Cheng
Author: Bee Wah Lee
Author: Lynette P. Shek
Author: Evelyn X.L. Loo

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