Prevalence of metachronous contralateral mature ovarian teratoma: a systematic review
Prevalence of metachronous contralateral mature ovarian teratoma: a systematic review
There is increasing recognition that contralateral metachronous tumor may occur following treatment of unilateral mature ovarian teratoma. We aimed to define this risk to guide appropriate surveillance strategies. We undertook a systematic review of three large medical databases (Ovid Medline, Embase, and Cochrane Controlled Trials Register) to April 2020 using a defined search strategy. From 1831 articles retrieved, 23 were included, reporting 1101 girls with unilateral mature ovarian teratomas. The intensity and duration of follow-up varied between studies, with only five reporting close surveillance. Overall prevalence of metachronous contralateral mature teratoma was 2.1%, with a prevalence per study of 0%–23% (median 0%). Prevalence was higher (7%) among studies with more robust surveillance. These data suggest a small but real risk of metachronous contralateral tumors. Surveillance ultrasonography is proportionate and indicated alongside further prospective data collection to record the natural history and impact of surveillance in greater detail.
mature teratoma, ovarian, pediatric, recurrence
Kiely, David
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Lewis, Carianne
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Gray, Juliet
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Hall, Nigel
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November 2021
Kiely, David
bd8affa0-af44-485f-b8b6-480f4c51f932
Lewis, Carianne
14181472-679b-435b-9be9-77daf4c0fb7d
Gray, Juliet
12d5e17c-97bb-4d6d-8fc4-3914b730ed42
Hall, Nigel
6919e8af-3890-42c1-98a7-c110791957cf
Kiely, David, Lewis, Carianne, Gray, Juliet and Hall, Nigel
(2021)
Prevalence of metachronous contralateral mature ovarian teratoma: a systematic review.
Pediatric Blood and Cancer, 68 (11), [e29237].
(doi:10.1002/pbc.29237).
Abstract
There is increasing recognition that contralateral metachronous tumor may occur following treatment of unilateral mature ovarian teratoma. We aimed to define this risk to guide appropriate surveillance strategies. We undertook a systematic review of three large medical databases (Ovid Medline, Embase, and Cochrane Controlled Trials Register) to April 2020 using a defined search strategy. From 1831 articles retrieved, 23 were included, reporting 1101 girls with unilateral mature ovarian teratomas. The intensity and duration of follow-up varied between studies, with only five reporting close surveillance. Overall prevalence of metachronous contralateral mature teratoma was 2.1%, with a prevalence per study of 0%–23% (median 0%). Prevalence was higher (7%) among studies with more robust surveillance. These data suggest a small but real risk of metachronous contralateral tumors. Surveillance ultrasonography is proportionate and indicated alongside further prospective data collection to record the natural history and impact of surveillance in greater detail.
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Prevalence of metachronous contralateral mature ovarian teratoma- a systematic review_R1-2
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Figure 2 - Risk of bias summary
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Accepted/In Press date: 6 July 2021
e-pub ahead of print date: 31 July 2021
Published date: November 2021
Additional Information:
Funding Information:
The authors would like to thank their families for their continued love and support.
Publisher Copyright:
© 2021 Wiley Periodicals LLC
Keywords:
mature teratoma, ovarian, pediatric, recurrence
Identifiers
Local EPrints ID: 450975
URI: http://eprints.soton.ac.uk/id/eprint/450975
ISSN: 1545-5017
PURE UUID: de579fe2-3974-4141-a900-6af72c580b39
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Date deposited: 31 Aug 2021 16:30
Last modified: 17 Mar 2024 06:42
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Author:
David Kiely
Author:
Carianne Lewis
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