Validation of EURO-D, a geriatric depression scale in South India: Findings from the Mysore Study of Natal effects on Ageing and Health (MYNAH).
Validation of EURO-D, a geriatric depression scale in South India: Findings from the Mysore Study of Natal effects on Ageing and Health (MYNAH).
Introduction: Many of the assessment tools used to study depression amongst older people in low- and middle- income countries (LMICs) are adaptations of instruments developed in other cultural settings. There is a need to validate those instruments in LMICs. Methods: 721 men and women aged 55–80 years from the Mysore Birth Records Cohort underwent standardised assessments for sociodemographic characteristics, cardiometabolic risk factors, cognitive function and mental health. Sensitivity, specificity and level of agreement of EURO-D diagnosis of depression with diagnosis of depression derived by the Geriatric Mental State (GMS) examination were calculated. To validate the EURO-D score against GMS depressive episode, we used maximum Youden's index as the criterion for each cut-off point. Concurrent validity was assessed by measuring correlations with the WHO Disability Assessment Schedule (WHO DAS II). Results: Of the 721 (408 men and 313 women) who participated in this study, 138 (54 men and 84 women) were diagnosed with depression. Women had higher depression scores on the EURO-D scale and disability on the WHO DAS II scale. A maximum Youden's Index of 0.60 was observed at a EURO-D cut-off of 6, which corresponded to 95% sensitivity, 64% specificity, kappa value of 0.6 and area under the curve (AUC) of 80%. There was significant and positive correlation between EURO-D and WHO DAS II scores. Limitations: Future independent validation studies in other settings are required. Discussion: This study supports the use of the EURO-D scale for diagnosing depression amongst older adults in South India.
EURO-D, Geriatric depression, India, Validation
939-945
Prajwal, V.
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Arun, Vanishri
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Rayma, M.C.
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Nagaraj, Santhosh
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Krishnaveni, G.V.
9a5fc779-af1c-402a-9b7e-078f2820534b
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Krishna, Murali
323774b9-e195-4608-8aa2-adb3d16f4637
1 December 2021
Prajwal, V.
bb41d9b0-bdbb-4c80-88cb-486fd4037364
Arun, Vanishri
8d33443b-4e54-4ca3-99d3-6372a84be057
Rayma, M.C.
d091bb38-f055-4011-8634-40539d9b1797
Nagaraj, Santhosh
424cfb5d-d472-4bdb-8182-0d0f80298de0
Krishnaveni, G.V.
9a5fc779-af1c-402a-9b7e-078f2820534b
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Krishna, Murali
323774b9-e195-4608-8aa2-adb3d16f4637
Prajwal, V., Arun, Vanishri, Rayma, M.C., Nagaraj, Santhosh, Krishnaveni, G.V., Fall, Caroline and Krishna, Murali
(2021)
Validation of EURO-D, a geriatric depression scale in South India: Findings from the Mysore Study of Natal effects on Ageing and Health (MYNAH).
Journal of Affective Disorders, 295, .
(doi:10.1016/j.jad.2021.08.045).
Abstract
Introduction: Many of the assessment tools used to study depression amongst older people in low- and middle- income countries (LMICs) are adaptations of instruments developed in other cultural settings. There is a need to validate those instruments in LMICs. Methods: 721 men and women aged 55–80 years from the Mysore Birth Records Cohort underwent standardised assessments for sociodemographic characteristics, cardiometabolic risk factors, cognitive function and mental health. Sensitivity, specificity and level of agreement of EURO-D diagnosis of depression with diagnosis of depression derived by the Geriatric Mental State (GMS) examination were calculated. To validate the EURO-D score against GMS depressive episode, we used maximum Youden's index as the criterion for each cut-off point. Concurrent validity was assessed by measuring correlations with the WHO Disability Assessment Schedule (WHO DAS II). Results: Of the 721 (408 men and 313 women) who participated in this study, 138 (54 men and 84 women) were diagnosed with depression. Women had higher depression scores on the EURO-D scale and disability on the WHO DAS II scale. A maximum Youden's Index of 0.60 was observed at a EURO-D cut-off of 6, which corresponded to 95% sensitivity, 64% specificity, kappa value of 0.6 and area under the curve (AUC) of 80%. There was significant and positive correlation between EURO-D and WHO DAS II scores. Limitations: Future independent validation studies in other settings are required. Discussion: This study supports the use of the EURO-D scale for diagnosing depression amongst older adults in South India.
Text
EuroD for JAD accepted version Aug 2021
- Accepted Manuscript
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Accepted/In Press date: 23 August 2021
e-pub ahead of print date: 27 August 2021
Published date: 1 December 2021
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We are grateful to participants and their families for their cooperation and participation in this study. We acknowledge the contributions of the present and previous staff at Holdsworth Memorial Hospital, Mysore. They include: Dr Sona Rao, Saroja A, Santhosh N, Somashekara R, Malathi MP, Pavithra Rani HD, Tony Gerald, Jayakumar MN, Geetha S, Annamma, Chachyamma, Tony Gerald Lawrence, Tony Clifford Onslow, Swaranagowri MN, Sulekha, Gopal Singh, Shylaja, Harini, Shobha, Poornima, Srinivas and Stephen Justine Manohar. We are thankful to the late Professor David JP Barker for his support in establishing the cohort and the research centre at CSI Holdsworth Memorial Hospital. We also thank other members of the MRC Lifecourse Epidemiology Unit, University of Southampton, UK, who have contributed to the Mysore Birth Records Cohort studies including Claudia Stein, Kumaran Kalyanaraman and Veena Sargur who created the cohort by tracing people born in HMH in 1993?1995. This study was supported by an Early Career Fellowship grant awarded to Dr Murali Krishna by Welcome DBT India Alliance.
Publisher Copyright:
© 2021
Keywords:
EURO-D, Geriatric depression, India, Validation
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Local EPrints ID: 451070
URI: http://eprints.soton.ac.uk/id/eprint/451070
ISSN: 0165-0327
PURE UUID: 34a3ef41-f053-4908-ae0d-0d8d3331bcd8
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Date deposited: 07 Sep 2021 16:30
Last modified: 17 Mar 2024 06:48
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Contributors
Author:
V. Prajwal
Author:
Vanishri Arun
Author:
M.C. Rayma
Author:
Santhosh Nagaraj
Author:
G.V. Krishnaveni
Author:
Murali Krishna
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