The University of Southampton
University of Southampton Institutional Repository

Long COVID and post-infective fatigue syndrome – a review

Long COVID and post-infective fatigue syndrome – a review
Long COVID and post-infective fatigue syndrome – a review

Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed "long-COVID"), with up to 46% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13% to 33% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10%-35% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.

Assessment, COVID-19, Cohorts, Fatigue, Post-viral
2328-8957
Sandler, Carolina X.
a66d7b7c-929d-4996-9474-ab3cc2b30140
Wyller, Vegard B.B.
7f951aba-2326-430b-80ea-602caec9443f
Moss-Morris, Rona
acfaee0f-af37-4a35-b1bb-e3cc40e87511
et al.,
96c90377-641f-4276-9d09-6968e3f36258
Little, Paul
1bf2d1f7-200c-47a5-ab16-fe5a8756a777
Sandler, Carolina X.
a66d7b7c-929d-4996-9474-ab3cc2b30140
Wyller, Vegard B.B.
7f951aba-2326-430b-80ea-602caec9443f
Moss-Morris, Rona
acfaee0f-af37-4a35-b1bb-e3cc40e87511
et al.,
96c90377-641f-4276-9d09-6968e3f36258
Little, Paul
1bf2d1f7-200c-47a5-ab16-fe5a8756a777

Sandler, Carolina X., Wyller, Vegard B.B., Moss-Morris, Rona, et al., and Little, Paul (2021) Long COVID and post-infective fatigue syndrome – a review. Open Forum Infectious Diseases, 8 (10), [ofab440]. (doi:10.1093/ofid/ofab440).

Record type: Article

Abstract

Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed "long-COVID"), with up to 46% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13% to 33% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10%-35% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.

Text
LongCOVID_PIFS Accepted_COFFI - Accepted Manuscript
Download (2MB)

More information

Accepted/In Press date: 12 August 2021
Published date: 7 October 2021
Additional Information: Funding Information: A. R. L. is supported by a National Health and Medical Research Council Practitioner Fellowship (Grant 1041897). C. X. S. is supported by the Mason Foundation National Medical Program. R. M.-M. is partly funded by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Keywords: Assessment, COVID-19, Cohorts, Fatigue, Post-viral

Identifiers

Local EPrints ID: 451071
URI: http://eprints.soton.ac.uk/id/eprint/451071
ISSN: 2328-8957
PURE UUID: 242ad5be-b562-47c9-991a-297f666de3ae
ORCID for Paul Little: ORCID iD orcid.org/0000-0003-3664-1873

Catalogue record

Date deposited: 07 Sep 2021 16:30
Last modified: 12 Jul 2024 01:35

Export record

Altmetrics

Contributors

Author: Carolina X. Sandler
Author: Vegard B.B. Wyller
Author: Rona Moss-Morris
Author: et al.
Author: Paul Little ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×