Long COVID and post-infective fatigue syndrome – a review
Long COVID and post-infective fatigue syndrome – a review
Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed "long-COVID"), with up to 46% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13% to 33% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10%-35% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.
Assessment, COVID-19, Cohorts, Fatigue, Post-viral
Sandler, Carolina X.
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Wyller, Vegard B.B.
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Moss-Morris, Rona
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et al.,
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Little, Paul
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7 October 2021
Sandler, Carolina X.
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Wyller, Vegard B.B.
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Moss-Morris, Rona
acfaee0f-af37-4a35-b1bb-e3cc40e87511
et al.,
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Little, Paul
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Sandler, Carolina X., Wyller, Vegard B.B., Moss-Morris, Rona, et al., and Little, Paul
(2021)
Long COVID and post-infective fatigue syndrome – a review.
Open Forum Infectious Diseases, 8 (10), [ofab440].
(doi:10.1093/ofid/ofab440).
Abstract
Fatigue is a dominant feature of both acute and convalescent coronavirus disease 2019 (COVID-19) (sometimes termed "long-COVID"), with up to 46% of patients reporting fatigue that lasts from weeks to months. The investigators of the international Collaborative on Fatigue Following Infection (COFFI) conducted a systematic review of post-COVID fatigue and a narrative review on fatigue after other infections, and made recommendations for clinical and research approaches to assessing fatigue after COVID-19. In the majority of COVID-19 cohort studies, persistent fatigue was reported by a significant minority of patients, ranging from 13% to 33% at 16-20 weeks post-symptom onset. Data from the prospective cohort studies in COFFI and others indicate that fatigue is also a prevalent outcome from many acute systemic infections, notably infectious mononucleosis, with a case rate for clinically significant Post-infective fatigue after exclusion of recognized medical and psychiatric causes, ranging from 10%-35% at 6 months. To better characterize post-COVID fatigue, the COFFI investigators recommend the following: application of validated screening questionnaires for case detection; standardized interviews encompassing fatigue, mood, and other symptoms; and investigative approaches to identify end-organ damage and mental health conditions.
Text
LongCOVID_PIFS Accepted_COFFI
- Accepted Manuscript
More information
Accepted/In Press date: 12 August 2021
Published date: 7 October 2021
Additional Information:
Funding Information:
A. R. L. is supported by a National Health and Medical Research Council Practitioner Fellowship (Grant 1041897). C. X. S. is supported by the Mason Foundation National Medical Program. R. M.-M. is partly funded by the NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London.
Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Keywords:
Assessment, COVID-19, Cohorts, Fatigue, Post-viral
Identifiers
Local EPrints ID: 451071
URI: http://eprints.soton.ac.uk/id/eprint/451071
ISSN: 2328-8957
PURE UUID: 242ad5be-b562-47c9-991a-297f666de3ae
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Date deposited: 07 Sep 2021 16:30
Last modified: 16 Mar 2024 13:47
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Author:
Carolina X. Sandler
Author:
Vegard B.B. Wyller
Author:
Rona Moss-Morris
Author:
et al.
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