The many antibiotic resistance and tolerance strategies of Pseudomonas aeruginosa
The many antibiotic resistance and tolerance strategies of Pseudomonas aeruginosa
Pseudomonas aeruginosa is a bacterial pathogen associated with a wide range of infections and utilizes several strategies to establish and maintain infection including biofilm production, multidrug resistance, and antibiotic tolerance. Multidrug resistance in P. aeruginosa, as well as in all other bacterial pathogens, is a growing concern. Aminoglycoside resistance, in particular, is a major concern in P. aeruginosa infections and must be better understood in order to maintain effective clinical treatment. In this review, the various antibiotic resistance and tolerance mechanisms of Pseudomonas are explored including: classic mutation driven resistance, adaptive resistance, persister cells, small colony variants, phoenix colonies, and biofilms. It is important to further characterize each of these phenotypes and continue to evaluate antibiotic surviving isolates for novel driving mechanisms, so that we are better prepared to combat the rising number of recurrent and recalcitrant infections.
Pseudomonas, Antibiotic Tolerance, Antibiotic Resistance, Biofilm
100056
Sindeldecker, Devin
53899a0e-6c67-40e4-813d-ce3e907f3ee8
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
December 2021
Sindeldecker, Devin
53899a0e-6c67-40e4-813d-ce3e907f3ee8
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Sindeldecker, Devin and Stoodley, Paul
(2021)
The many antibiotic resistance and tolerance strategies of Pseudomonas aeruginosa.
Biofilm, 3, , [100056].
(doi:10.1016/j.bioflm.2021.100056).
Abstract
Pseudomonas aeruginosa is a bacterial pathogen associated with a wide range of infections and utilizes several strategies to establish and maintain infection including biofilm production, multidrug resistance, and antibiotic tolerance. Multidrug resistance in P. aeruginosa, as well as in all other bacterial pathogens, is a growing concern. Aminoglycoside resistance, in particular, is a major concern in P. aeruginosa infections and must be better understood in order to maintain effective clinical treatment. In this review, the various antibiotic resistance and tolerance mechanisms of Pseudomonas are explored including: classic mutation driven resistance, adaptive resistance, persister cells, small colony variants, phoenix colonies, and biofilms. It is important to further characterize each of these phenotypes and continue to evaluate antibiotic surviving isolates for novel driving mechanisms, so that we are better prepared to combat the rising number of recurrent and recalcitrant infections.
Text
Antibiotic Tolerance and Resistance Review Revised
- Accepted Manuscript
Text
1-s2.0-S2590207521000149-main (1)
- Version of Record
More information
Accepted/In Press date: 18 August 2021
e-pub ahead of print date: 21 August 2021
Published date: December 2021
Additional Information:
© 2021 The Authors. Published by Elsevier B.V.
Keywords:
Pseudomonas, Antibiotic Tolerance, Antibiotic Resistance, Biofilm
Identifiers
Local EPrints ID: 451146
URI: http://eprints.soton.ac.uk/id/eprint/451146
ISSN: 2590-2075
PURE UUID: 463abbde-7fff-4b3f-ada7-e7b126657cac
Catalogue record
Date deposited: 14 Sep 2021 15:23
Last modified: 17 Mar 2024 03:18
Export record
Altmetrics
Contributors
Author:
Devin Sindeldecker
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
