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COVID-19 and metabolic disease: mechanisms and clinical management

COVID-19 and metabolic disease: mechanisms and clinical management
COVID-19 and metabolic disease: mechanisms and clinical management
Up to 50% of the people who have died from COVID-19 had metabolic and vascular disorders. Notably, there are many direct links between COVID-19 and the metabolic and endocrine systems. Thus, not only are patients with metabolic dysfunction (eg, obesity, hypertension, non-alcoholic fatty liver disease, and diabetes) at an increased risk of developing severe COVID-19 but also infection with SARS-CoV-2 might lead to new-onset diabetes or aggravation of pre-existing metabolic disorders. In this Review, we provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19. Additionally, we update the practical recommendations and management of patients with COVID-19 and post-pandemic. Furthermore, we summarise new treatment options for patients with both COVID-19 and diabetes, and highlight current challenges in clinical management.
2213-8587
786 - 798
Holt, Richard
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Steeenblock, Charlotte
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Schwarz, Peter E H
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Ludwig, Barbara
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Linkermann, Andreas
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Zimmet, Paul
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Kulebyakin, Konstantin
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Tkachuk, Vsevolod A
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Markov, Alexander G
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Lehnert, Hendrik
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Hrabe de Angelis, Martin
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Rietzsch, Hannes
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Rodionov, Roman N
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Khunti, Kamlesh
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Hopkins, David
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Birkenfeld, Andreas L
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Boehm, Bernhard
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Skyler, Jay S
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DeVries, J Hans
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Renard, Eric
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Eckel, Robert H
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Alberti, K George M M
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Geloneze, Bruno
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Chan, Juliana C
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Mbanya, Jean Claude
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Onyegbutulem, Henry C
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Ramachandran, Ambady
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Basit, Abdul
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Hassanein, Mohammed
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Bewick, Gavin
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Spinas, Giatgen A
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Beuschlein, Felix
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Landgraf, Rudiger
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Rubino, Francesco
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Mingrone, Geltrude
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Bornstein, Stefan R
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Holt, Richard
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Steeenblock, Charlotte
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Schwarz, Peter E H
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Ludwig, Barbara
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Linkermann, Andreas
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Zimmet, Paul
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Kulebyakin, Konstantin
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Tkachuk, Vsevolod A
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Markov, Alexander G
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Hrabe de Angelis, Martin
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Khunti, Kamlesh
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Hopkins, David
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Birkenfeld, Andreas L
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Boehm, Bernhard
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Skyler, Jay S
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DeVries, J Hans
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Renard, Eric
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Eckel, Robert H
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Alberti, K George M M
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Geloneze, Bruno
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Chan, Juliana C
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Mbanya, Jean Claude
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Onyegbutulem, Henry C
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Hassanein, Mohammed
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Bewick, Gavin
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Spinas, Giatgen A
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Beuschlein, Felix
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Landgraf, Rudiger
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Rubino, Francesco
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Mingrone, Geltrude
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Bornstein, Stefan R
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Holt, Richard, Steeenblock, Charlotte, Schwarz, Peter E H, Ludwig, Barbara, Linkermann, Andreas, Zimmet, Paul, Kulebyakin, Konstantin, Tkachuk, Vsevolod A, Markov, Alexander G, Lehnert, Hendrik, Hrabe de Angelis, Martin, Rietzsch, Hannes, Rodionov, Roman N, Khunti, Kamlesh, Hopkins, David, Birkenfeld, Andreas L, Boehm, Bernhard, Skyler, Jay S, DeVries, J Hans, Renard, Eric, Eckel, Robert H, Alberti, K George M M, Geloneze, Bruno, Chan, Juliana C, Mbanya, Jean Claude, Onyegbutulem, Henry C, Ramachandran, Ambady, Basit, Abdul, Hassanein, Mohammed, Bewick, Gavin, Spinas, Giatgen A, Beuschlein, Felix, Landgraf, Rudiger, Rubino, Francesco, Mingrone, Geltrude and Bornstein, Stefan R (2021) COVID-19 and metabolic disease: mechanisms and clinical management. The Lancet Diabetes & Endocrinology, 9 (11), 786 - 798. (doi:10.1016/S2213-8587(21)00244-8).

Record type: Article

Abstract

Up to 50% of the people who have died from COVID-19 had metabolic and vascular disorders. Notably, there are many direct links between COVID-19 and the metabolic and endocrine systems. Thus, not only are patients with metabolic dysfunction (eg, obesity, hypertension, non-alcoholic fatty liver disease, and diabetes) at an increased risk of developing severe COVID-19 but also infection with SARS-CoV-2 might lead to new-onset diabetes or aggravation of pre-existing metabolic disorders. In this Review, we provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19. Additionally, we update the practical recommendations and management of patients with COVID-19 and post-pandemic. Furthermore, we summarise new treatment options for patients with both COVID-19 and diabetes, and highlight current challenges in clinical management.

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e-pub ahead of print date: 4 October 2021
Published date: 4 October 2021

Identifiers

Local EPrints ID: 452172
URI: http://eprints.soton.ac.uk/id/eprint/452172
DOI: doi:10.1016/S2213-8587(21)00244-8
ISSN: 2213-8587
PURE UUID: 562741c1-587e-4e04-8997-cbb93d0e3901
ORCID for Richard Holt: ORCID iD orcid.org/0000-0001-8911-6744

Catalogue record

Date deposited: 26 Nov 2021 17:34
Last modified: 17 Mar 2024 06:56

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Contributors

Author: Richard Holt ORCID iD
Author: Charlotte Steeenblock
Author: Peter E H Schwarz
Author: Barbara Ludwig
Author: Andreas Linkermann
Author: Paul Zimmet
Author: Konstantin Kulebyakin
Author: Vsevolod A Tkachuk
Author: Alexander G Markov
Author: Hendrik Lehnert
Author: Martin Hrabe de Angelis
Author: Hannes Rietzsch
Author: Roman N Rodionov
Author: Kamlesh Khunti
Author: David Hopkins
Author: Andreas L Birkenfeld
Author: Bernhard Boehm
Author: Jay S Skyler
Author: J Hans DeVries
Author: Eric Renard
Author: Robert H Eckel
Author: K George M M Alberti
Author: Bruno Geloneze
Author: Juliana C Chan
Author: Jean Claude Mbanya
Author: Henry C Onyegbutulem
Author: Ambady Ramachandran
Author: Abdul Basit
Author: Mohammed Hassanein
Author: Gavin Bewick
Author: Giatgen A Spinas
Author: Felix Beuschlein
Author: Rudiger Landgraf
Author: Francesco Rubino
Author: Geltrude Mingrone
Author: Stefan R Bornstein

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