Quantifying skin sensitivity caused by mechanical insults: A review
Quantifying skin sensitivity caused by mechanical insults: A review
Background: Skin sensitivity (SS) is a commonly occurring response to a range of stimuli, including environmental conditions (e.g., sun exposure), chemical irritants (e.g., soaps and cosmetics), and mechanical forces (e.g., while shaving). From both industry and academia, many efforts have been taken to quantify the characteristics of SS in a standardised manner, but the study is hindered by the lack of an objective definition. Methods: A review of the scientific literature regarding different parameters attributed to the loss of skin integrity and linked with exhibition of SS was conducted. Articles included were screened for mechanical stimulation of the skin, with objective quantification of tissue responses using biophysical or imaging techniques. Additionally, studies where cohorts of SS and non-SS individuals were reported have been critiqued. Results: The findings identified that the structure and function of the stratum corneum and its effective barrier properties are closely associated with SS. Thus, an array of skin tissue responses has been selected for characterization of SS due to mechanical stimuli, including: transepidermal water loss, hydration, redness, temperature, and sebum index. Additionally, certain imaging tools allow quantification of the superficial skin layers, providing structural characteristics underlying SS. Conclusion: This review proposes a multimodal approach for identification of SS, providing a means to characterise skin tissue responses objectively. Optical coherence tomography (OCT) has been suggested as a suitable tool for dermatological research with clinical applications. Such an approach would enhance the knowledge underlying the multifactorial nature of SS and aid the development of personalised solutions in medical and consumer devices.
OCT, biophysical, imaging, mechanical stimuli, multimodal analysis, sensitive skin
Chaturvedi, Pakhi
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Worsley, Peter R.
6d33aee3-ef43-468d-aef6-86d190de6756
Zanelli, Giulia
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Kroon, Wilco
40633fdc-17f8-404b-8236-8e7cd3d8b7be
Bader, Dan L.
06079726-5aa3-49cd-ad71-402ab4cd3255
27 October 2021
Chaturvedi, Pakhi
f24c30f6-0a45-404a-9c61-0f66b20ca8d3
Worsley, Peter R.
6d33aee3-ef43-468d-aef6-86d190de6756
Zanelli, Giulia
d0ebb72b-b06b-4787-b864-874a5c6c81ea
Kroon, Wilco
40633fdc-17f8-404b-8236-8e7cd3d8b7be
Bader, Dan L.
06079726-5aa3-49cd-ad71-402ab4cd3255
Chaturvedi, Pakhi, Worsley, Peter R., Zanelli, Giulia, Kroon, Wilco and Bader, Dan L.
(2021)
Quantifying skin sensitivity caused by mechanical insults: A review.
Skin Research and Technology.
(doi:10.1111/srt.13104).
Abstract
Background: Skin sensitivity (SS) is a commonly occurring response to a range of stimuli, including environmental conditions (e.g., sun exposure), chemical irritants (e.g., soaps and cosmetics), and mechanical forces (e.g., while shaving). From both industry and academia, many efforts have been taken to quantify the characteristics of SS in a standardised manner, but the study is hindered by the lack of an objective definition. Methods: A review of the scientific literature regarding different parameters attributed to the loss of skin integrity and linked with exhibition of SS was conducted. Articles included were screened for mechanical stimulation of the skin, with objective quantification of tissue responses using biophysical or imaging techniques. Additionally, studies where cohorts of SS and non-SS individuals were reported have been critiqued. Results: The findings identified that the structure and function of the stratum corneum and its effective barrier properties are closely associated with SS. Thus, an array of skin tissue responses has been selected for characterization of SS due to mechanical stimuli, including: transepidermal water loss, hydration, redness, temperature, and sebum index. Additionally, certain imaging tools allow quantification of the superficial skin layers, providing structural characteristics underlying SS. Conclusion: This review proposes a multimodal approach for identification of SS, providing a means to characterise skin tissue responses objectively. Optical coherence tomography (OCT) has been suggested as a suitable tool for dermatological research with clinical applications. Such an approach would enhance the knowledge underlying the multifactorial nature of SS and aid the development of personalised solutions in medical and consumer devices.
Text
srt.13104
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Quantifying skin sensitivity caused by mechanical insults a review
More information
Accepted/In Press date: 21 August 2021
e-pub ahead of print date: 27 October 2021
Published date: 27 October 2021
Additional Information:
Funding Information:
The work was carried out as part of the project ‘Skin Tissue Integrity under Shear’ (STINTS) that is funded from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie Grant Agreement No. 811965.
Publisher Copyright:
© 2021 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd.
Keywords:
OCT, biophysical, imaging, mechanical stimuli, multimodal analysis, sensitive skin
Identifiers
Local EPrints ID: 452637
URI: http://eprints.soton.ac.uk/id/eprint/452637
ISSN: 0909-752X
PURE UUID: 35f8b2f4-af92-4267-90cf-216229b8a390
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Date deposited: 11 Dec 2021 11:30
Last modified: 17 Mar 2024 06:56
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Contributors
Author:
Pakhi Chaturvedi
Author:
Giulia Zanelli
Author:
Wilco Kroon
Author:
Dan L. Bader
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