Correctly computing targeting efficiency in magnetically targeted delivery from particle tracking models

Podoliak, Nina and Richardson, Giles (2022) Correctly computing targeting efficiency in magnetically targeted delivery from particle tracking models. Journal of Magnetism and Magnetic Materials, 549, [168960]. (doi:10.1016/j.jmmm.2021.168960).

Record type: Article

Abstract

The aim of this work is to correct a widely occurring, but subtle, error in the interpretation of models of magnetically targeted delivery. This can result in
inaccuracies in the predicted targeting efficiency of up to an order of magnitude. In order to correct this error a model for magnetic targeting that is based upon a particle conservation law is developed. The close relationship between this model and the standard approach is demonstrated. Interpretation of magnetic particle dynamics in terms of a conservation law leads to an improved understanding of the overall process and results in an alternative, and correct, definition of the targeting efficiency. It is shown that when the predicted magnetic particle trajectories are used to compute the targeting efficiency, based on this alternative definition, it yields a prediction that compares much more favourably to the results of a simple in-vitro experiment [28] than when the same particle trajectories are used to compute the targeting efficiency based on the standard, but erroneous, definition.

Text

Target_effic_accept - Accepted Manuscript

Available under License Creative Commons Attribution Non-commercial No Derivatives.

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