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Ferroptosis and metabolic dysfunction-associated fatty liver disease: is there a link?

Ferroptosis and metabolic dysfunction-associated fatty liver disease: is there a link?
Ferroptosis and metabolic dysfunction-associated fatty liver disease: is there a link?
Non-alcoholic fatty liver disease (NAFLD), recently re-defined and re-classified as metabolic dysfunction-associated fatty liver disease (MAFLD), has become increasingly prevalent and emerged as a public health problem worldwide. To date, the precise pathogenic mechanisms underpinning MAFLD are not entirely understood, and there is no effective pharmacological therapy for NAFLD/MAFLD. As a newly discovered form of iron-dependent programmed cell death, ferroptosis can be involved in the development and progression of various chronic diseases, but the pathogenic connections and mechanisms that link MAFLD and ferroptosis have not been fully elucidated. The main characteristics of ferroptosis are the accumulation of lipid peroxides and reactive oxygen species. In this brief narrative review, the mechanisms of ferroptosis and its putative pathogenic role in MAFLD are discussed to highlight potential new research directions and ideas for the prevention and treatment of MAFLD.
1478-3223
1496-1502
Feng, Gong
3bb0f07d-e371-412e-a04e-ed89abe18672
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni
9ee4f188-846e-4ef7-85b9-4c03cc092d10
Wang, Fudi
0ec3db8b-abca-4542-b8a4-2818e9ae6691
Zheng, Ming-Hua
93a0c970-8c84-4ebb-a35b-2134c4e0ee47
Feng, Gong
3bb0f07d-e371-412e-a04e-ed89abe18672
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni
9ee4f188-846e-4ef7-85b9-4c03cc092d10
Wang, Fudi
0ec3db8b-abca-4542-b8a4-2818e9ae6691
Zheng, Ming-Hua
93a0c970-8c84-4ebb-a35b-2134c4e0ee47

Feng, Gong, Byrne, Christopher, Targher, Giovanni, Wang, Fudi and Zheng, Ming-Hua (2022) Ferroptosis and metabolic dysfunction-associated fatty liver disease: is there a link? Liver International, 42 (7), 1496-1502. (doi:10.1111/liv.15163).

Record type: Review

Abstract

Non-alcoholic fatty liver disease (NAFLD), recently re-defined and re-classified as metabolic dysfunction-associated fatty liver disease (MAFLD), has become increasingly prevalent and emerged as a public health problem worldwide. To date, the precise pathogenic mechanisms underpinning MAFLD are not entirely understood, and there is no effective pharmacological therapy for NAFLD/MAFLD. As a newly discovered form of iron-dependent programmed cell death, ferroptosis can be involved in the development and progression of various chronic diseases, but the pathogenic connections and mechanisms that link MAFLD and ferroptosis have not been fully elucidated. The main characteristics of ferroptosis are the accumulation of lipid peroxides and reactive oxygen species. In this brief narrative review, the mechanisms of ferroptosis and its putative pathogenic role in MAFLD are discussed to highlight potential new research directions and ideas for the prevention and treatment of MAFLD.

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More information

Accepted/In Press date: 4 January 2022
e-pub ahead of print date: 10 January 2022
Published date: 1 July 2022
Additional Information: © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Identifiers

Local EPrints ID: 454029
URI: http://eprints.soton.ac.uk/id/eprint/454029
ISSN: 1478-3223
PURE UUID: 04befaaa-b941-45b2-a7f6-7396323340a1
ORCID for Christopher Byrne: ORCID iD orcid.org/0000-0001-6322-7753

Catalogue record

Date deposited: 27 Jan 2022 18:48
Last modified: 22 Jan 2023 05:01

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Contributors

Author: Gong Feng
Author: Giovanni Targher
Author: Fudi Wang
Author: Ming-Hua Zheng

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