The haematology of Jamaicans: red cell indices in HbAA, HbAS, HbAC, and HbA-HPFH genotypes
The haematology of Jamaicans: red cell indices in HbAA, HbAS, HbAC, and HbA-HPFH genotypes
Based in the parish of Manchester in central Jamaica, the Manchester Project offered free detection of haemoglobin genotype to senior classes in 15 secondary schools between 2008 and 2013. Restricting the database to 15,103 students aged 15.0–19.9 years provided an opportunity to examine the red cell characteristics of the different haemoglobin genotypes, including normal (HbAA) in 85.0%, the sickle cell trait (HbAS) in 9.7%, HbC trait (HbAC) in 3.5% and hereditary persistence of foetal haemoglobin (HbA-HPFH) in 0.4%. Compared to the normal HbAA phenotype, HbAS had significantly increased mean cell haemoglobin concentration (MCHC), red cell count (RBC), and red cell distribution width (RDW) and decreased mean cell volume (MCV) and mean cell haemoglobin (MCH), these differences being even more marked in HbAC. Compared to HbAA, the HbA-HPFH had significantly increased RDW, but there were no consistent differences in other red cell indices, and there were no significant differences in haematological indices between the two common deletion HPFH variants, HPFH-1 and HPFH-2. Although these changes are unlikely to be clinically significant, they contribute to an understanding of the haematological spectrum of the common haemoglobin genotypes in peoples of African origin.
Haemoglobin C trait, Jamaica, Normal AA genotype, Red cell indices, Sickle cell trait
229-234
Serjeant, G.R.
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Serjeant, B.E.
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Mason, K.P.
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Gibson, F.
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Osmond, Clive
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Thein, S.L.
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Happich, M.
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Kulozik, A.E
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1 April 2022
Serjeant, G.R.
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Serjeant, B.E.
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Mason, K.P.
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Gibson, F.
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Osmond, Clive
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Thein, S.L.
ad5ff1c1-121c-43e8-90e4-90bb3ddc4eba
Happich, M.
c7b237ad-ead9-46bc-bf08-4f23b3016d8d
Kulozik, A.E
c38c5e40-1e44-4638-b1de-0572c11c0149
Serjeant, G.R., Serjeant, B.E., Mason, K.P., Gibson, F., Osmond, Clive, Thein, S.L., Happich, M. and Kulozik, A.E
(2022)
The haematology of Jamaicans: red cell indices in HbAA, HbAS, HbAC, and HbA-HPFH genotypes.
Journal of Community Genetics, 13 (2), .
(doi:10.1007/s12687-021-00575-8).
Abstract
Based in the parish of Manchester in central Jamaica, the Manchester Project offered free detection of haemoglobin genotype to senior classes in 15 secondary schools between 2008 and 2013. Restricting the database to 15,103 students aged 15.0–19.9 years provided an opportunity to examine the red cell characteristics of the different haemoglobin genotypes, including normal (HbAA) in 85.0%, the sickle cell trait (HbAS) in 9.7%, HbC trait (HbAC) in 3.5% and hereditary persistence of foetal haemoglobin (HbA-HPFH) in 0.4%. Compared to the normal HbAA phenotype, HbAS had significantly increased mean cell haemoglobin concentration (MCHC), red cell count (RBC), and red cell distribution width (RDW) and decreased mean cell volume (MCV) and mean cell haemoglobin (MCH), these differences being even more marked in HbAC. Compared to HbAA, the HbA-HPFH had significantly increased RDW, but there were no consistent differences in other red cell indices, and there were no significant differences in haematological indices between the two common deletion HPFH variants, HPFH-1 and HPFH-2. Although these changes are unlikely to be clinically significant, they contribute to an understanding of the haematological spectrum of the common haemoglobin genotypes in peoples of African origin.
Text
Haem indices submitted
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More information
Accepted/In Press date: 22 December 2021
Published date: 1 April 2022
Additional Information:
Funding Information:
This study was supported by the National Health Fund of Jamaica under Grant HPP70 and by Jamalco
Funding Information:
School screening was supported by the National Health Fund of Jamaica and Jamalco.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Keywords:
Haemoglobin C trait, Jamaica, Normal AA genotype, Red cell indices, Sickle cell trait
Identifiers
Local EPrints ID: 454216
URI: http://eprints.soton.ac.uk/id/eprint/454216
PURE UUID: 1ed254b6-8702-4ac5-98f8-abc5076b9e6e
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Date deposited: 02 Feb 2022 17:52
Last modified: 17 Mar 2024 07:04
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Contributors
Author:
G.R. Serjeant
Author:
B.E. Serjeant
Author:
K.P. Mason
Author:
F. Gibson
Author:
S.L. Thein
Author:
M. Happich
Author:
A.E Kulozik
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