Parental preconception BMI trajectories from childhood to adolescence and asthma in the future offspring
Parental preconception BMI trajectories from childhood to adolescence and asthma in the future offspring
Background
Recent evidence suggests that parental exposures before conception can increase the risk of asthma in offspring.
Objective
We investigated the association between parents' preconception body mass index (BMI) trajectories from childhood to adolescence and subsequent risk of asthma in their offspring.
Methods
Using group-based trajectory modeling from the Tasmanian Longitudinal Health Study, we identified BMI trajectories for index participants (parents) when aged 4 years to 15 years. Multinomial regression models adjusted for potential confounders were utilized to estimate the association between these early-life parents' BMI trajectories and asthma phenotypes in their subsequent offspring.
Results
The main analysis included 1822 parents and 4208 offspring. Four BMI trajectories from age 4 years to 15 years were identified as the best-fitting model: low (8.8%), normal (44.1%), above normal (40.2%), and high (7.0%). Associations were observed between father’s high BMI trajectory and risk of asthma in offspring before the age of 10 years (relative risk ratio [RRR] =1.70 [95% CI = 0.98-2.93]) and also asthma ever (RRR = 1.72 [95% CI = 1.00-2.97]), especially allergic asthma ever (RRR = 2.05 [95% CI = 1.12-3.72]). These associations were not mediated by offspring birth weight. No associations were observed for maternal BMI trajectories and offspring asthma phenotypes.
Conclusion
This cohort study over 6 decades of life and across 2 generations suggests that the high BMI trajectory in fathers, well before conception, increased the risk of asthma in their offspring.
Body mass index, asthma, epigenetics, intergenerational, preconception, transgenerational
67-74.e30
Bowatte, Gayan
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Bui, Dinh
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Priyankara, Sajith
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Lowe, Adrian J.
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Perret, Jennifer L.
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Lodge, Caroline J.
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Hamilton, Garun S.
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Erbas, Bircan
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Thomas, Paul
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Thompson, Bruce
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Schlünssen, Vivi
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Martino, David
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Holloway, John W.
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Svanes, Cecilie
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Abramson, Michael J.
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Walters, E. Haydn
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Dharmage, Shyamali C.
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8 January 2022
Bowatte, Gayan
1d07b318-ea1a-46e8-8046-31ea85b9e3da
Bui, Dinh
15750bb8-eb32-48b5-ba6f-f3f0aca177cd
Priyankara, Sajith
4224b66d-5447-4e4f-9417-5ff56cc99230
Lowe, Adrian J.
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Perret, Jennifer L.
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Lodge, Caroline J.
4857af90-4ecf-413c-a354-11685d499de6
Hamilton, Garun S.
e51c7b9f-e5de-4291-8a50-1aba886c91c1
Erbas, Bircan
3c9ad62e-66a1-4ead-af74-9aea44546bdb
Thomas, Paul
8af4831d-4ae4-4c29-bc1d-01b278ec650c
Thompson, Bruce
0b7b7407-57cb-4502-9e32-152a2f3b0c2f
Schlünssen, Vivi
872b391d-a114-4392-9701-265792601c79
Martino, David
d483381d-4912-4b75-a457-6b5f49900936
Holloway, John W.
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Svanes, Cecilie
4a547f80-e3d3-47b4-ae0a-2741ad93c629
Abramson, Michael J.
deb3d27e-6b6d-4be3-a441-ef9e40795dc1
Walters, E. Haydn
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Dharmage, Shyamali C.
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Bowatte, Gayan, Bui, Dinh, Priyankara, Sajith, Lowe, Adrian J., Perret, Jennifer L., Lodge, Caroline J., Hamilton, Garun S., Erbas, Bircan, Thomas, Paul, Thompson, Bruce, Schlünssen, Vivi, Martino, David, Holloway, John W., Svanes, Cecilie, Abramson, Michael J., Walters, E. Haydn and Dharmage, Shyamali C.
(2022)
Parental preconception BMI trajectories from childhood to adolescence and asthma in the future offspring.
Journal of Allergy and Clinical Immunology, 150 (1), .
(doi:10.1016/j.jaci.2021.11.028).
Abstract
Background
Recent evidence suggests that parental exposures before conception can increase the risk of asthma in offspring.
Objective
We investigated the association between parents' preconception body mass index (BMI) trajectories from childhood to adolescence and subsequent risk of asthma in their offspring.
Methods
Using group-based trajectory modeling from the Tasmanian Longitudinal Health Study, we identified BMI trajectories for index participants (parents) when aged 4 years to 15 years. Multinomial regression models adjusted for potential confounders were utilized to estimate the association between these early-life parents' BMI trajectories and asthma phenotypes in their subsequent offspring.
Results
The main analysis included 1822 parents and 4208 offspring. Four BMI trajectories from age 4 years to 15 years were identified as the best-fitting model: low (8.8%), normal (44.1%), above normal (40.2%), and high (7.0%). Associations were observed between father’s high BMI trajectory and risk of asthma in offspring before the age of 10 years (relative risk ratio [RRR] =1.70 [95% CI = 0.98-2.93]) and also asthma ever (RRR = 1.72 [95% CI = 1.00-2.97]), especially allergic asthma ever (RRR = 2.05 [95% CI = 1.12-3.72]). These associations were not mediated by offspring birth weight. No associations were observed for maternal BMI trajectories and offspring asthma phenotypes.
Conclusion
This cohort study over 6 decades of life and across 2 generations suggests that the high BMI trajectory in fathers, well before conception, increased the risk of asthma in their offspring.
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More information
Accepted/In Press date: 24 November 2021
e-pub ahead of print date: 8 January 2022
Published date: 8 January 2022
Additional Information:
Funding Information:
Supported by the National Health and Medical Research Council (NHMRC) of Australia (grants 299901 and 1021275 ); the University of Melbourne, Australia; the Clifford Craig Foundation, Australia; the Victorian, Queensland, and Tasmanian Asthma Foundations, Australia; Royal Hobart Hospital, Australia; the Helen MacPherson Smith Trust, Australia; GlaxoSmithKline, Australia; and John L. Hopper. G.B., J.P., A.L., C.L., and S.C.D. are funded through the NHMRC of Australia . The sponsors of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.
Publisher Copyright:
© 2022 American Academy of Allergy, Asthma & Immunology
Keywords:
Body mass index, asthma, epigenetics, intergenerational, preconception, transgenerational
Identifiers
Local EPrints ID: 454350
URI: http://eprints.soton.ac.uk/id/eprint/454350
ISSN: 0091-6749
PURE UUID: 6dcb4206-72b1-49c9-a080-e2ba89198789
Catalogue record
Date deposited: 07 Feb 2022 17:55
Last modified: 17 Mar 2024 07:03
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Contributors
Author:
Gayan Bowatte
Author:
Dinh Bui
Author:
Sajith Priyankara
Author:
Adrian J. Lowe
Author:
Jennifer L. Perret
Author:
Caroline J. Lodge
Author:
Garun S. Hamilton
Author:
Bircan Erbas
Author:
Paul Thomas
Author:
Bruce Thompson
Author:
Vivi Schlünssen
Author:
David Martino
Author:
Cecilie Svanes
Author:
Michael J. Abramson
Author:
E. Haydn Walters
Author:
Shyamali C. Dharmage
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