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HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management
HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

Human papillomavirus (HPV)-positive (HPV +) oropharyngeal squamous cell carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high-income countries. The most recent (8th) edition of the UICC/AJCC staging system separates HPV + OPSCC from its HPV-negative (HPV ) counterpart to account for the improved prognosis seen in the former. Indeed, owing to its improved prognosis and greater prevalence in younger individuals, numerous ongoing trials are examining the potential for treatment de-intensification as a means to improve quality of life while maintaining acceptable survival outcomes. In addition, owing to the distinct biology of HPV + OPSCCs, targeted therapies and immunotherapies have become an area of particular interest. Importantly, OPSCC is often detected at an advanced stage owing to a lack of symptoms in the early stages; therefore, a need exists to identify and validate possible diagnostic biomarkers to aid in earlier detection. In this Review, we provide a summary of the epidemiology, molecular biology and clinical management of HPV + OPSCC in an effort to highlight important advances in the field. Ultimately, a need exists for improved understanding of the molecular basis and clinical course of this disease to guide efforts towards early detection and precision care, and to improve patient outcomes.

1759-4774
306-327
Lechner, Matt
327faa2a-e083-46bb-8da6-337114f3a172
Liu, Jacklyn
f5c703b4-a2d3-44f9-9581-fb72bfb1f105
Masterson, Liam
6c6cee63-03c7-4cea-8c69-2f2f77d3e50d
Fenton, Tim R.
087260ba-f6a1-405a-85df-099d05810a84
Lechner, Matt
327faa2a-e083-46bb-8da6-337114f3a172
Liu, Jacklyn
f5c703b4-a2d3-44f9-9581-fb72bfb1f105
Masterson, Liam
6c6cee63-03c7-4cea-8c69-2f2f77d3e50d
Fenton, Tim R.
087260ba-f6a1-405a-85df-099d05810a84

Lechner, Matt, Liu, Jacklyn, Masterson, Liam and Fenton, Tim R. (2022) HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management. Nature Reviews Clinical Oncology, 19 (5), 306-327. (doi:10.1038/s41571-022-00603-7).

Record type: Review

Abstract

Human papillomavirus (HPV)-positive (HPV +) oropharyngeal squamous cell carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high-income countries. The most recent (8th) edition of the UICC/AJCC staging system separates HPV + OPSCC from its HPV-negative (HPV ) counterpart to account for the improved prognosis seen in the former. Indeed, owing to its improved prognosis and greater prevalence in younger individuals, numerous ongoing trials are examining the potential for treatment de-intensification as a means to improve quality of life while maintaining acceptable survival outcomes. In addition, owing to the distinct biology of HPV + OPSCCs, targeted therapies and immunotherapies have become an area of particular interest. Importantly, OPSCC is often detected at an advanced stage owing to a lack of symptoms in the early stages; therefore, a need exists to identify and validate possible diagnostic biomarkers to aid in earlier detection. In this Review, we provide a summary of the epidemiology, molecular biology and clinical management of HPV + OPSCC in an effort to highlight important advances in the field. Ultimately, a need exists for improved understanding of the molecular basis and clinical course of this disease to guide efforts towards early detection and precision care, and to improve patient outcomes.

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Restricted to Repository staff only until 13 January 2023.
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Accepted/In Press date: 13 January 2022
e-pub ahead of print date: 1 February 2022
Published date: May 2022

Identifiers

Local EPrints ID: 454563
URI: http://eprints.soton.ac.uk/id/eprint/454563
ISSN: 1759-4774
PURE UUID: 0b3530f8-d4f4-4c84-b8c5-395183758518
ORCID for Tim R. Fenton: ORCID iD orcid.org/0000-0002-4737-8233

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Date deposited: 16 Feb 2022 17:35
Last modified: 28 Jun 2022 02:06

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Contributors

Author: Matt Lechner
Author: Jacklyn Liu
Author: Liam Masterson
Author: Tim R. Fenton ORCID iD

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