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Associations between child filaggrin mutations and maternal diet with the development of allergic diseases in children

Associations between child filaggrin mutations and maternal diet with the development of allergic diseases in children
Associations between child filaggrin mutations and maternal diet with the development of allergic diseases in children
Background
Filaggrin (FLG) loss-of-function mutations in children and maternal diet in pregnancy have been implicated in child allergy outcomes. This paper studies the questions: “do FLG mutations modify the effect of maternal diet on the odds of development of allergic diseases?” and “which factor leads to the highest rate of diagnosis allergic diseases over time, maternal diet, or FLG mutations?”.

Methods
Exact logistic regressions studied effect modification. Cox proportional hazard models compared the rate of allergic disease development in three groups (N = 624): (1) children with FLG mutation, (2) children without FLG mutation whose mothers did not eat an allergy preventive diet, and (3) children without FLG mutation whose mothers ate an allergy preventive diet. Maternal diet was classified using a validated index.

Results
Cox models showed the development of atopic dermatitis, asthma, and wheeze was significantly higher for children in group 1 versus 3 (HR = 2.40 [1.32, 4.37], HR = 2.29 [1.05, 4.97], and HR 2.10 [1.004, 4.38], respectively), but not significantly higher for children in group 1 versus 2 (HR = 1.30 [0.74, 2.29], HR = 1.27 [0.61, 2.63], and HR = 1.29 [0.65, 2.58], respectively). Development of allergic rhinitis was significantly higher for group 1 versus 2 and 3 (1 vs. 2: HR = 2.29 [1.10, 4.76]; 1 vs. 3: HR = 3.21 [1.46, 7.08]). There was no significant effect modification for any outcome.

Conclusion
Children with FLG mutation had similar risk of atopic dermatitis, asthma, and wheeze as children without an FLG mutation whose mothers did not eat an allergy preventive diet during pregnancy. Child FLG mutation did not modify the effect of maternal diet. The results suggest that maternal diet in pregnancy, a modifiable risk factor, could be a target for preventive interventions.
FLG mutation, allergic rhinitis, allergy, asthma, atopic dermatitis, filaggrin, maternal diet, pregnancy, prevention
0905-6157
Venter, Carina
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Palumbo, Michaela P.
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Sauder, Katherine A.
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Glueck, Deborah H.
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O’mahony, Liam
fab1543f-d033-4b4a-b267-99948c8c2a52
Yang, Ivana
ffb15dcd-ac2e-43bf-a2cc-443ff692f526
Davidson, Elizabeth J.
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Brough, Helen A.
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Holloway, John W.
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Fleischer, David M.
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Ben‐abdallah, Miriam
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Dabelea, Dana
ac81e62b-06c8-48cd-801f-03f17eeaf559
Venter, Carina
a9b7dd5e-b0cb-4068-be82-e15b587cc20b
Palumbo, Michaela P.
080f7999-6458-454c-a7ef-615b6248c196
Sauder, Katherine A.
6ab7fb57-feb5-4991-8255-a32fea18f0bd
Glueck, Deborah H.
3fb4c978-b918-4f19-a3dd-a5ff6248e3db
O’mahony, Liam
fab1543f-d033-4b4a-b267-99948c8c2a52
Yang, Ivana
ffb15dcd-ac2e-43bf-a2cc-443ff692f526
Davidson, Elizabeth J.
2cc61857-c382-42cb-95ee-ab6dca15dc37
Brough, Helen A.
ad550b22-eed8-4a61-9703-bd16aea45873
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Fleischer, David M.
085e52de-faaa-41a9-8eba-47ff70f8a99d
Ben‐abdallah, Miriam
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Dabelea, Dana
ac81e62b-06c8-48cd-801f-03f17eeaf559

Venter, Carina, Palumbo, Michaela P., Sauder, Katherine A., Glueck, Deborah H., O’mahony, Liam, Yang, Ivana, Davidson, Elizabeth J., Brough, Helen A., Holloway, John W., Fleischer, David M., Ben‐abdallah, Miriam and Dabelea, Dana (2022) Associations between child filaggrin mutations and maternal diet with the development of allergic diseases in children. Pediatric Allergy and Immunology, 33 (3), [e13753]. (doi:10.1111/pai.13753).

Record type: Article

Abstract

Background
Filaggrin (FLG) loss-of-function mutations in children and maternal diet in pregnancy have been implicated in child allergy outcomes. This paper studies the questions: “do FLG mutations modify the effect of maternal diet on the odds of development of allergic diseases?” and “which factor leads to the highest rate of diagnosis allergic diseases over time, maternal diet, or FLG mutations?”.

Methods
Exact logistic regressions studied effect modification. Cox proportional hazard models compared the rate of allergic disease development in three groups (N = 624): (1) children with FLG mutation, (2) children without FLG mutation whose mothers did not eat an allergy preventive diet, and (3) children without FLG mutation whose mothers ate an allergy preventive diet. Maternal diet was classified using a validated index.

Results
Cox models showed the development of atopic dermatitis, asthma, and wheeze was significantly higher for children in group 1 versus 3 (HR = 2.40 [1.32, 4.37], HR = 2.29 [1.05, 4.97], and HR 2.10 [1.004, 4.38], respectively), but not significantly higher for children in group 1 versus 2 (HR = 1.30 [0.74, 2.29], HR = 1.27 [0.61, 2.63], and HR = 1.29 [0.65, 2.58], respectively). Development of allergic rhinitis was significantly higher for group 1 versus 2 and 3 (1 vs. 2: HR = 2.29 [1.10, 4.76]; 1 vs. 3: HR = 3.21 [1.46, 7.08]). There was no significant effect modification for any outcome.

Conclusion
Children with FLG mutation had similar risk of atopic dermatitis, asthma, and wheeze as children without an FLG mutation whose mothers did not eat an allergy preventive diet during pregnancy. Child FLG mutation did not modify the effect of maternal diet. The results suggest that maternal diet in pregnancy, a modifiable risk factor, could be a target for preventive interventions.

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Accepted/In Press date: 16 February 2022
Published date: 2 March 2022
Additional Information: Funding Information: This work was supported by the National Institutes of Health (NIH), grant numbers: R01 DK076648/DK/NIDDK NIH HHS/United States, R01 GM121081/GM/NIGMS NIH HHS/United States, UG3 OD023248/OD/NIH HHS/United States, UH3 OD023248/OD/NIH HHS/United States, R25GM111901-S1, R25GM11190, NIH grant R00ES025817. This work was supported by the National Institutes of Health (NIH), grant numbers: R01 DK076648/DK/NIDDK NIH HHS/United States, R01 GM121081/GM/NIGMS NIH HHS/United States, UG3 OD023248/OD/NIH HHS/United States, UH3 OD023248/OD/NIH HHS/United States, R25GM111901-S1, R25GM11190, NIH grant R00ES025817. Funding Information: This work was supported by University of Buenos Aires (UBACyT 20020130100610BA for MJ & 2002017010755BA for BCB), Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT PICT 2012-1167 for MJ), Fundación Argentina de Nanotecnología (Proyecto Presemillas for BCB) and National Research Council of Argentina (CONICET PIP 11220170100991CO for MJ). Authors thanks Dr. Claudia Marchi for her remarkable help in the FESEM images. VO is a member of ALN. Publisher Copyright: © 2022 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
Keywords: FLG mutation, allergic rhinitis, allergy, asthma, atopic dermatitis, filaggrin, maternal diet, pregnancy, prevention

Identifiers

Local EPrints ID: 455716
URI: http://eprints.soton.ac.uk/id/eprint/455716
ISSN: 0905-6157
PURE UUID: 0913fed5-7534-457e-b185-6de0462be158
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

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Date deposited: 31 Mar 2022 16:34
Last modified: 17 Mar 2024 07:10

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Contributors

Author: Carina Venter
Author: Michaela P. Palumbo
Author: Katherine A. Sauder
Author: Deborah H. Glueck
Author: Liam O’mahony
Author: Ivana Yang
Author: Elizabeth J. Davidson
Author: Helen A. Brough
Author: David M. Fleischer
Author: Miriam Ben‐abdallah
Author: Dana Dabelea

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