Age- and sex-specific effects of obesity, metabolic syndrome and its components on back pain: The English Longitudinal Study of Ageing.
Age- and sex-specific effects of obesity, metabolic syndrome and its components on back pain: The English Longitudinal Study of Ageing.
Objectives
We aimed to investigate age- and sex-specific effects of obesity, metabolic syndrome (MetS) and its components on back pain in middle-aged and older English individuals.
Methods
We used data from the English Longitudinal Study of Ageing, wave 2 (2004–2005). Body mass index (BMI) expressed the obesity, while MetS was defined according to revised Adult Treatment Panel (ATP) III criteria. We assessed associations between obesity, MetS and its components with presence and severity of back pain and provided estimates per strata, middle-aged (50–64 years) and older (65–79 years), women and men.
Results
The study sample included 3328 participants, 1021 and 835 middle-aged women and men and 773 and 699 older women and men, respectively. We found that BMI (OR = 1.07, 95% CI 1.05–1.09), MetS (OR = 1.47, 95% CI 1.22–1.77), high waist circumference (WC), high triglycerides (TG), and high fasting blood glucose were associated with the presence of back pain. Effects of BMI were consistent across the strata. However, MetS was associated with back pain only in women, middle-aged (OR = 1.59, 95% CI 1.14–2.21) and older (OR = 1.43, 95% CI 1.01–2.05). The MetS component driving this association was high WC, supported by high TG in older women. Higher BMI, presence of MetS, high blood pressure and TG were associated with back pain severity.
Conclusions
We found that obesity was associated with the presence and severity of back pain, irrespective of age and sex. However, we found women-specific effects of MetS driven by high WC, indicating that metabolic dysregulation contributes to back pain pathophysiology in women.
Back pain, Body mass index, Metabolic syndrome, Sex differences, Waist circumference
Perera, Romain S.
41222096-6830-4e20-a2fb-b7f18a9ad9b6
Chen, Lingxiao
15a40a3b-0f1e-4686-adb8-b9ebc723792a
Ferreira, Manuela L.
908e590e-f84c-4f9e-8fb6-26501b014deb
Arden, Nigel
23af958d-835c-4d79-be54-4bbe4c68077f
Radojčić, Maja R.
b2003caf-f95c-4cb4-8215-50e2e96873b7
Kluzek, Stefan
02edaad0-3ec7-4c71-a5fc-ffae0a870dff
October 2022
Perera, Romain S.
41222096-6830-4e20-a2fb-b7f18a9ad9b6
Chen, Lingxiao
15a40a3b-0f1e-4686-adb8-b9ebc723792a
Ferreira, Manuela L.
908e590e-f84c-4f9e-8fb6-26501b014deb
Arden, Nigel
23af958d-835c-4d79-be54-4bbe4c68077f
Radojčić, Maja R.
b2003caf-f95c-4cb4-8215-50e2e96873b7
Kluzek, Stefan
02edaad0-3ec7-4c71-a5fc-ffae0a870dff
Perera, Romain S., Chen, Lingxiao, Ferreira, Manuela L., Arden, Nigel, Radojčić, Maja R. and Kluzek, Stefan
(2022)
Age- and sex-specific effects of obesity, metabolic syndrome and its components on back pain: The English Longitudinal Study of Ageing.
Joint Bone Spine, 89 (5), [105366].
(doi:10.1016/j.jbspin.2022.105366).
Abstract
Objectives
We aimed to investigate age- and sex-specific effects of obesity, metabolic syndrome (MetS) and its components on back pain in middle-aged and older English individuals.
Methods
We used data from the English Longitudinal Study of Ageing, wave 2 (2004–2005). Body mass index (BMI) expressed the obesity, while MetS was defined according to revised Adult Treatment Panel (ATP) III criteria. We assessed associations between obesity, MetS and its components with presence and severity of back pain and provided estimates per strata, middle-aged (50–64 years) and older (65–79 years), women and men.
Results
The study sample included 3328 participants, 1021 and 835 middle-aged women and men and 773 and 699 older women and men, respectively. We found that BMI (OR = 1.07, 95% CI 1.05–1.09), MetS (OR = 1.47, 95% CI 1.22–1.77), high waist circumference (WC), high triglycerides (TG), and high fasting blood glucose were associated with the presence of back pain. Effects of BMI were consistent across the strata. However, MetS was associated with back pain only in women, middle-aged (OR = 1.59, 95% CI 1.14–2.21) and older (OR = 1.43, 95% CI 1.01–2.05). The MetS component driving this association was high WC, supported by high TG in older women. Higher BMI, presence of MetS, high blood pressure and TG were associated with back pain severity.
Conclusions
We found that obesity was associated with the presence and severity of back pain, irrespective of age and sex. However, we found women-specific effects of MetS driven by high WC, indicating that metabolic dysregulation contributes to back pain pathophysiology in women.
Text
Manuscript_MetS_20220214MRR_accepted
- Accepted Manuscript
More information
Accepted/In Press date: 2 February 2022
e-pub ahead of print date: 25 February 2022
Published date: October 2022
Additional Information:
Funding Information:
The present study was supported by Versus Arthritis through Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis Grant Number 21595.
Publisher Copyright:
© 2022 Société française de rhumatologie
Keywords:
Back pain, Body mass index, Metabolic syndrome, Sex differences, Waist circumference
Identifiers
Local EPrints ID: 455770
URI: http://eprints.soton.ac.uk/id/eprint/455770
ISSN: 1297-319X
PURE UUID: 297fdd2a-cc2b-4e94-bf8c-9afbe2141d80
Catalogue record
Date deposited: 04 Apr 2022 16:35
Last modified: 17 Mar 2024 07:11
Export record
Altmetrics
Contributors
Author:
Romain S. Perera
Author:
Lingxiao Chen
Author:
Manuela L. Ferreira
Author:
Maja R. Radojčić
Author:
Stefan Kluzek
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics