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Associations between maternal distress during early life periods and offspring respiratory infections and allergic outcomes

Associations between maternal distress during early life periods and offspring respiratory infections and allergic outcomes
Associations between maternal distress during early life periods and offspring respiratory infections and allergic outcomes
Background: increasing evidence suggests that maternal distress is a risk factor for development of respiratory infections and allergic diseases in the offspring. We aim to evaluate the link between maternal distress during critical periods in early life, namely the preconception, pregnancy and postnatal periods, and development of respiratory infections and allergic diseases in the offspring from the Singapore PREconception Study of long Term maternal and child Outcomes (S-PRESTO) cohort.

Methods: maternal perceived distress was evaluated using validated questionnaires including Beck Depression Inventory-II (BDI-II) administered during three time periods: preconception (three months apart at four timepoints), pregnancy (during each trimester) and postnatal (3 and 6 months post-delivery). Child eczema, rhinitis and wheeze outcomes were evaluated using a modified ISAAC questionnaire at ages 3, 6, 12, and 18 months. Child allergic sensitization was determined by skin prick testing at 18 months.

Results: among 332 mother-child pairs studied, higher maternal distress during preconception and pregnancy increased the risks of wheeze development in the first 18 months; for example, preconception and pregnancy BDI-II scores ≥20 were associated with increased risks of wheeze by 18 months [adjusted risk ratios 3.2 (95%CI 1.1–9.4) and 2.5 (1.0–5.9), respectively]. Emotional and practical support from family during preconception decreased the risks of offspring wheeze. No associations were observed between maternal distress and offspring eczema, rhinitis and allergic sensitization.

Conclusion: maternal distress during critical early life periods was associated with offspring wheeze in the first 18 months of life. Supporting maternal mental health even before pregnancy could reduce the risk of offspring wheeze.
allergic sensitization, eczema, maternal distress, postnatal, preconception, pregnancy, rhinitis, wheeze
2296-2360
Lau, Hui Xing
31f26ca2-82af-47d4-9077-84a4ebc19ba8
Kee, Michelle Zhi Ling
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Yap, Qai Ven
ccb659a8-9154-46cd-8c86-57f3de54ff6e
Tham, Elizabeth Huiwen
e22014ec-8242-478a-aafc-e4177164f814
Chan, Yiong Huak
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Goh, Anne Eng Neo
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Teoh, Oon Hoe
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Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
Godfrey, Keith
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Gluckman, Peter D.
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Chong, Yap-Seng
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Chan, Jerry KY
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van Bever, Hugo
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Lee, Bee Wah
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Shek, Lynette Pei-Chi
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Meaney, Michael J.
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Loo, Evelyn Xiu-Ling
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Lau, Hui Xing
31f26ca2-82af-47d4-9077-84a4ebc19ba8
Kee, Michelle Zhi Ling
b10a1ed0-e2ab-40bf-bba0-471e5f7ae601
Yap, Qai Ven
ccb659a8-9154-46cd-8c86-57f3de54ff6e
Tham, Elizabeth Huiwen
e22014ec-8242-478a-aafc-e4177164f814
Chan, Yiong Huak
6e604543-7616-48cc-a07e-86a80dfa5df0
Goh, Anne Eng Neo
9d869111-5368-420f-97dc-336f052bef41
Teoh, Oon Hoe
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Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
Godfrey, Keith
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Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Chong, Yap-Seng
7043124b-e892-4d4b-8bb7-6d35ed94e136
Chan, Jerry KY
42e59d61-c3d1-486b-b33a-22c4645acf12
van Bever, Hugo
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Lee, Bee Wah
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Shek, Lynette Pei-Chi
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Meaney, Michael J.
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Loo, Evelyn Xiu-Ling
229ed4b9-220f-4d95-a384-eb6529f6d2d6

Lau, Hui Xing, Kee, Michelle Zhi Ling, Yap, Qai Ven, Tham, Elizabeth Huiwen, Chan, Yiong Huak, Goh, Anne Eng Neo, Teoh, Oon Hoe, Eriksson, Johan G., Godfrey, Keith, Gluckman, Peter D., Chong, Yap-Seng, Chan, Jerry KY, van Bever, Hugo, Lee, Bee Wah, Shek, Lynette Pei-Chi, Meaney, Michael J. and Loo, Evelyn Xiu-Ling (2022) Associations between maternal distress during early life periods and offspring respiratory infections and allergic outcomes. Frontiers in Pediatrics, 10, [749323]. (doi:10.3389/fped.2022.749323).

Record type: Article

Abstract

Background: increasing evidence suggests that maternal distress is a risk factor for development of respiratory infections and allergic diseases in the offspring. We aim to evaluate the link between maternal distress during critical periods in early life, namely the preconception, pregnancy and postnatal periods, and development of respiratory infections and allergic diseases in the offspring from the Singapore PREconception Study of long Term maternal and child Outcomes (S-PRESTO) cohort.

Methods: maternal perceived distress was evaluated using validated questionnaires including Beck Depression Inventory-II (BDI-II) administered during three time periods: preconception (three months apart at four timepoints), pregnancy (during each trimester) and postnatal (3 and 6 months post-delivery). Child eczema, rhinitis and wheeze outcomes were evaluated using a modified ISAAC questionnaire at ages 3, 6, 12, and 18 months. Child allergic sensitization was determined by skin prick testing at 18 months.

Results: among 332 mother-child pairs studied, higher maternal distress during preconception and pregnancy increased the risks of wheeze development in the first 18 months; for example, preconception and pregnancy BDI-II scores ≥20 were associated with increased risks of wheeze by 18 months [adjusted risk ratios 3.2 (95%CI 1.1–9.4) and 2.5 (1.0–5.9), respectively]. Emotional and practical support from family during preconception decreased the risks of offspring wheeze. No associations were observed between maternal distress and offspring eczema, rhinitis and allergic sensitization.

Conclusion: maternal distress during critical early life periods was associated with offspring wheeze in the first 18 months of life. Supporting maternal mental health even before pregnancy could reduce the risk of offspring wheeze.

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More information

Accepted/In Press date: 16 February 2022
e-pub ahead of print date: 30 March 2022
Published date: 30 March 2022
Additional Information: Funding Information: This work is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme, administered by the Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore-NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science and Technology. KG is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research [NIHR Senior Investigator (NF-SI-0515-10042) and NIHR Southampton Biomedical Research Centre (IS-BRC-1215-20004)], the European Union (Erasmus+ Programme ImpENSA 598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP) and the British Heart Foundation (RG/15/17/3174). Funding Information: We thank the S-PRESTO study group and all clinical and home-visit staff involved. The voluntary participation of all participants is greatly appreciated. The S-PRESTO study group includes includes Airu Chia, Anna Magdalena Fogel, AG, Anne Hin Yee Chu, Anne Rifkin-Graboi, Anqi Qiu, BL, Bobby Kyungbeom Cheon, Candida Vaz, Christiani Jeyakumar Henry, Ciaran Gerard Forde, Claudia Chi, Dawn Xin Ping Koh, Desiree Y. Phua, Doris Ngiuk Lan Loh, Elaine Phaik Ling Quah, Elizabeth Huiwen Tham, Evelyn Chung Ning Law, Faidon Magkos, Falk Mueller-Riemenschneider, George Seow Heong Yeo, Hannah Ee Juen Yong, Helen Yu Chen, Heng Hao Tan, Hong Pan, Hugo P S van Bever, Hui Min Tan, Izzuddin Bin Mohd Aris, Jeannie Tay, JC, Jia Xu, Joanne Su-Yin Yoong, JE, Jonathan Tze Liang Choo, Jonathan Y. Bernard, Jonathan Yinhao Huang, Jun Shi Lai, Karen Mei Ling Tan, KG, Kenneth Yung Chiang Kwek, Keri McCrickerd, Kothandaraman Narasimhan, Kok Wee Chong, Kuan Jin Lee, Li Chen, Lieng Hsi Ling, Ling-Wei Chen, Lourdes Mary Daniel, LS, Marielle V. Fortier, Mary Foong-Fong Chong, Mei Chien Chua, Melvin Khee-Shing Leow, Michelle Zhi Ling Kee, Min Gong, Mya Thway Tint, Navin Michael, Ngee Lek, OT, Priti Mishra, Queenie Ling Jun Li, Sambasivam Sendhil Velan, Seng Bin Ang, Shirong Cai, Si Hui Goh, Sok Bee Lim, Stella Tsotsi, Stephen Chin-Ying Hsu, Sue-Anne Ee Shiow Toh, Suresh Anand Sadananthan, Teng Hong Tan, Tong Wei Yew, Varsha Gupta, Victor Samuel Rajadurai, Wee Meng Han, Wei Wei Pang, Wen Lun Yuan, Yanan Zhu, Yin Bun Cheung, Yiong Huak Chan and Zai Ru Cheng. Publisher Copyright: Copyright © 2022 Lau, Kee, Yap, Tham, Chan, Goh, Teoh, Eriksson, Godfrey, Gluckman, Chong, Chan, Van Bever, Lee, Shek, Meaney and Loo. Copyright: Copyright 2022 Elsevier B.V., All rights reserved.
Keywords: allergic sensitization, eczema, maternal distress, postnatal, preconception, pregnancy, rhinitis, wheeze

Identifiers

Local EPrints ID: 455995
URI: http://eprints.soton.ac.uk/id/eprint/455995
ISSN: 2296-2360
PURE UUID: c2a60c49-cf84-4fce-b08b-bfab29c07eb0
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 12 Apr 2022 16:30
Last modified: 17 Mar 2024 02:38

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Contributors

Author: Hui Xing Lau
Author: Michelle Zhi Ling Kee
Author: Qai Ven Yap
Author: Elizabeth Huiwen Tham
Author: Yiong Huak Chan
Author: Anne Eng Neo Goh
Author: Oon Hoe Teoh
Author: Johan G. Eriksson
Author: Keith Godfrey ORCID iD
Author: Peter D. Gluckman
Author: Yap-Seng Chong
Author: Jerry KY Chan
Author: Hugo van Bever
Author: Bee Wah Lee
Author: Lynette Pei-Chi Shek
Author: Michael J. Meaney
Author: Evelyn Xiu-Ling Loo

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