Preterm birth and infant diurnal cortisol regulation
Preterm birth and infant diurnal cortisol regulation
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy. METHODS: A secondary analysis was conducted of saliva cortisol measured morning, midday and evening, monthly, across infancy, as part of a birth cohort conducted in Linköping, Sweden. Diurnal cortisol regulation of infants born extremely preterm (n=24), very preterm (n=27) and at term (n=130) were compared across infancy through random coefficients regression models. RESULTS: Compared with infants born at term, infants born extremely preterm (-17.2%, 95% CI: -30.7 to -1.2), but not very preterm (1.7%, 95% CI: -14.1 to 20.4), had a flattened diurnal slope across infancy. CONCLUSIONS: Extremely preterm birth is associated with a flattened diurnal slope in infancy. This pattern of cortisol regulation could contribute to adverse metabolic and neurodevelopmental phenotypes observed in this population.
endocrinology, infant development
565-567
Stoye, David Q
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Boardman, James P.
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Osmond, Clive
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Sullivan, Gemma
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Lamb, Gillian
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Black, Gill S.
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Homer, Natalie Z.
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Nelson, Nina
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Theodorsson, Elvar
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Reynolds, Rebecca M.
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Morelius, Evalotte
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1 September 2022
Stoye, David Q
ff298889-64e8-4f3e-96ed-9a4f145f1dbd
Boardman, James P.
28ce9bba-1bff-40c3-968c-666d8a11b0dd
Osmond, Clive
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Sullivan, Gemma
aaa8f78b-b1c6-4b8d-9285-89d8fd5947ac
Lamb, Gillian
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Black, Gill S.
e3df84f7-347c-4341-98af-eaff5ade7e6c
Homer, Natalie Z.
bfe271fd-80ca-410b-a50b-5a0305f2705c
Nelson, Nina
4ebaddea-8464-47c0-9948-09a3047aec6a
Theodorsson, Elvar
eff50eca-0be0-467e-82a0-5e9442573615
Reynolds, Rebecca M.
0e42554c-fafd-447c-99ec-19b024c47302
Morelius, Evalotte
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Stoye, David Q, Boardman, James P., Osmond, Clive, Sullivan, Gemma, Lamb, Gillian, Black, Gill S., Homer, Natalie Z., Nelson, Nina, Theodorsson, Elvar, Reynolds, Rebecca M. and Morelius, Evalotte
(2022)
Preterm birth and infant diurnal cortisol regulation.
Archives of Disease in Childhood: Fetal and Neonatal Edition, 107 (5), , [archdischild-2021-323296].
(doi:10.1136/archdischild-2021-323296).
Abstract
BACKGROUND: Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy. METHODS: A secondary analysis was conducted of saliva cortisol measured morning, midday and evening, monthly, across infancy, as part of a birth cohort conducted in Linköping, Sweden. Diurnal cortisol regulation of infants born extremely preterm (n=24), very preterm (n=27) and at term (n=130) were compared across infancy through random coefficients regression models. RESULTS: Compared with infants born at term, infants born extremely preterm (-17.2%, 95% CI: -30.7 to -1.2), but not very preterm (1.7%, 95% CI: -14.1 to 20.4), had a flattened diurnal slope across infancy. CONCLUSIONS: Extremely preterm birth is associated with a flattened diurnal slope in infancy. This pattern of cortisol regulation could contribute to adverse metabolic and neurodevelopmental phenotypes observed in this population.
Text
Preterm birth and infant diurnal cortisol regulation
- Accepted Manuscript
More information
Accepted/In Press date: 11 February 2022
e-pub ahead of print date: 14 March 2022
Published date: 1 September 2022
Additional Information:
Funding Information:
We are grateful to the families who consented to participate in the cohort. This study was funded by Theirworld (www.theirworld.org) and was undertaken in the MRC Centre for Reproductive Health, which is funded by MRC Centre Grant (MRC G1002033). RMR acknowledges the support of the British Heart Foundation (RE/18/5/34216). EM acknowledge Perth Children’s Hospital Foundation for supporting the professorial position.
Publisher Copyright:
© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
Keywords:
endocrinology, infant development
Identifiers
Local EPrints ID: 456162
URI: http://eprints.soton.ac.uk/id/eprint/456162
ISSN: 1359-2998
PURE UUID: 688eab3a-d926-452e-aae4-023589757ddf
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Date deposited: 26 Apr 2022 15:10
Last modified: 17 Mar 2024 02:42
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Contributors
Author:
David Q Stoye
Author:
James P. Boardman
Author:
Gemma Sullivan
Author:
Gillian Lamb
Author:
Gill S. Black
Author:
Natalie Z. Homer
Author:
Nina Nelson
Author:
Elvar Theodorsson
Author:
Rebecca M. Reynolds
Author:
Evalotte Morelius
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