Platinum-based chemotherapy ‘Rechallenge’ in advanced non-ovarian solid malignancies
Platinum-based chemotherapy ‘Rechallenge’ in advanced non-ovarian solid malignancies
Platinum-based chemotherapy forms the backbone of treatment for many solid cancers. However, resistance inevitably develops in those with advanced disease. Platinum rechallenge is a well-established concept in the management of ovarian cancer, small cell lung cancer and germ cell tumours. In other solid malignancies there is a lack of quality evidence to support platinum rechallenge, yet it is a widely adopted strategy. Often, patients are within the last year of life, making questions of efficacy, treatment-related toxicity and quality of life critical factors for treatment recommendations. In this overview we appraise the available evidence for platinum rechallenge and strategies being developed to attempt resensitisation of tumours to platinum-based chemotherapy.
Carboplatin, chemotherapy, cisplatin, rechallenge, resistance
e329-e344
Hack, Joanna
a79b6801-0771-4fe7-a632-e3413b6ffe6f
Crabb, Simon
bcd1b566-7677-4f81-8429-3ab0e85f8373
August 2022
Hack, Joanna
a79b6801-0771-4fe7-a632-e3413b6ffe6f
Crabb, Simon
bcd1b566-7677-4f81-8429-3ab0e85f8373
Hack, Joanna and Crabb, Simon
(2022)
Platinum-based chemotherapy ‘Rechallenge’ in advanced non-ovarian solid malignancies.
Clinical Oncology, 34 (8), .
(doi:10.1016/j.clon.2022.02.015).
Abstract
Platinum-based chemotherapy forms the backbone of treatment for many solid cancers. However, resistance inevitably develops in those with advanced disease. Platinum rechallenge is a well-established concept in the management of ovarian cancer, small cell lung cancer and germ cell tumours. In other solid malignancies there is a lack of quality evidence to support platinum rechallenge, yet it is a widely adopted strategy. Often, patients are within the last year of life, making questions of efficacy, treatment-related toxicity and quality of life critical factors for treatment recommendations. In this overview we appraise the available evidence for platinum rechallenge and strategies being developed to attempt resensitisation of tumours to platinum-based chemotherapy.
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Overview - platinum rechallenge
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Accepted/In Press date: 17 February 2022
e-pub ahead of print date: 11 March 2022
Published date: August 2022
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© 2022 The Authors
Keywords:
Carboplatin, chemotherapy, cisplatin, rechallenge, resistance
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Local EPrints ID: 456407
URI: http://eprints.soton.ac.uk/id/eprint/456407
ISSN: 0936-6555
PURE UUID: 9d679b58-65a2-4ddc-bf0c-f5c36d95a8c1
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Date deposited: 28 Apr 2022 16:33
Last modified: 17 Mar 2024 07:13
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Author:
Joanna Hack
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