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Platinum-based chemotherapy ‘Rechallenge’ in advanced non-ovarian solid malignancies

Platinum-based chemotherapy ‘Rechallenge’ in advanced non-ovarian solid malignancies
Platinum-based chemotherapy ‘Rechallenge’ in advanced non-ovarian solid malignancies
Platinum-based chemotherapy forms the backbone of treatment for many solid cancers. However, resistance inevitably develops in those with advanced disease. Platinum rechallenge is a well-established concept in the management of ovarian cancer, small cell lung cancer and germ cell tumours. In other solid malignancies there is a lack of quality evidence to support platinum rechallenge, yet it is a widely adopted strategy. Often, patients are within the last year of life, making questions of efficacy, treatment-related toxicity and quality of life critical factors for treatment recommendations. In this overview we appraise the available evidence for platinum rechallenge and strategies being developed to attempt resensitisation of tumours to platinum-based chemotherapy.
Carboplatin, chemotherapy, cisplatin, rechallenge, resistance
0936-6555
Hack, Joanna
a79b6801-0771-4fe7-a632-e3413b6ffe6f
Crabb, Simon
bcd1b566-7677-4f81-8429-3ab0e85f8373
Hack, Joanna
a79b6801-0771-4fe7-a632-e3413b6ffe6f
Crabb, Simon
bcd1b566-7677-4f81-8429-3ab0e85f8373

Hack, Joanna and Crabb, Simon (2022) Platinum-based chemotherapy ‘Rechallenge’ in advanced non-ovarian solid malignancies. Clinical Oncology. (doi:10.1016/j.clon.2022.02.015).

Record type: Article

Abstract

Platinum-based chemotherapy forms the backbone of treatment for many solid cancers. However, resistance inevitably develops in those with advanced disease. Platinum rechallenge is a well-established concept in the management of ovarian cancer, small cell lung cancer and germ cell tumours. In other solid malignancies there is a lack of quality evidence to support platinum rechallenge, yet it is a widely adopted strategy. Often, patients are within the last year of life, making questions of efficacy, treatment-related toxicity and quality of life critical factors for treatment recommendations. In this overview we appraise the available evidence for platinum rechallenge and strategies being developed to attempt resensitisation of tumours to platinum-based chemotherapy.

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Overview - platinum rechallenge
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Accepted/In Press date: 17 February 2022
e-pub ahead of print date: 11 March 2022
Published date: 11 March 2022
Keywords: Carboplatin, chemotherapy, cisplatin, rechallenge, resistance

Identifiers

Local EPrints ID: 456407
URI: http://eprints.soton.ac.uk/id/eprint/456407
ISSN: 0936-6555
PURE UUID: 9d679b58-65a2-4ddc-bf0c-f5c36d95a8c1
ORCID for Simon Crabb: ORCID iD orcid.org/0000-0003-3521-9064

Catalogue record

Date deposited: 28 Apr 2022 16:33
Last modified: 21 Jun 2022 01:36

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Contributors

Author: Joanna Hack
Author: Simon Crabb ORCID iD

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