From hurdle to springboard: the macrophage as target in biomaterial-based bone regeneration strategies
From hurdle to springboard: the macrophage as target in biomaterial-based bone regeneration strategies
The past decade has seen a growing appreciation for the role of the innate immune response in mediating repair and biomaterial directed tissue regeneration. The long-held view of the host immune/inflammatory response as an obstacle limiting stem cell regenerative activity, has given way to a fresh appreciation of the pivotal role the macrophage plays in orchestrating the resolution of inflammation and launching the process of remodelling and repair. In the context of bone, work over the past decade has established an essential coordinating role for macrophages in supporting bone repair and sustaining biomaterial driven osteogenesis. In this review evidence for the role of the macrophage in bone regeneration and repair is surveyed before discussing recent biomaterial and drug-delivery based approaches that target macrophage modulation with the goal of accelerating and enhancing bone tissue regeneration.
Bone, Macrophage, immune response, inflammation, scaffold, tissue regeneration
Kim, Yang-Hee
de0d641b-c2cb-4e73-9ae2-e20d33689f5d
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dawson, Jonathan I.
b220fe76-498d-47be-9995-92da6c289cf3
24 March 2022
Kim, Yang-Hee
de0d641b-c2cb-4e73-9ae2-e20d33689f5d
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dawson, Jonathan I.
b220fe76-498d-47be-9995-92da6c289cf3
Kim, Yang-Hee, Oreffo, Richard O.C. and Dawson, Jonathan I.
(2022)
From hurdle to springboard: the macrophage as target in biomaterial-based bone regeneration strategies.
Bone, 159, [116389].
(doi:10.1016/j.bone.2022.116389).
Abstract
The past decade has seen a growing appreciation for the role of the innate immune response in mediating repair and biomaterial directed tissue regeneration. The long-held view of the host immune/inflammatory response as an obstacle limiting stem cell regenerative activity, has given way to a fresh appreciation of the pivotal role the macrophage plays in orchestrating the resolution of inflammation and launching the process of remodelling and repair. In the context of bone, work over the past decade has established an essential coordinating role for macrophages in supporting bone repair and sustaining biomaterial driven osteogenesis. In this review evidence for the role of the macrophage in bone regeneration and repair is surveyed before discussing recent biomaterial and drug-delivery based approaches that target macrophage modulation with the goal of accelerating and enhancing bone tissue regeneration.
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Accepted/In Press date: 11 March 2022
e-pub ahead of print date: 14 March 2022
Published date: 24 March 2022
Additional Information:
Funding Information:
Work in the authors' laboratories was supported by the MRC-AMED Regenerative Medicine and Stem Cell Research Initiative (ref. MR/V00543X/1 ), the EPSRC (ref.EP/S017054/1), U.K. Regenerative Medicine Platform ( MR/R015651/1 ) the Rosetrees Trust and Wessex Medical Research and Biotechnology and Biological Sciences Research Council ( BB/P017711/1 ). The work presented has arisen from many useful discussions derived from past and current members of the Bone and Joint Research Group in Southampton as well as fruitful collaborations, in particular Professor Yasuhiko Tabata, Kyoto University. We apologise to those authors whose valuable work it was not possible to cite due to restrictions of space.
Keywords:
Bone, Macrophage, immune response, inflammation, scaffold, tissue regeneration
Identifiers
Local EPrints ID: 456616
URI: http://eprints.soton.ac.uk/id/eprint/456616
ISSN: 8756-3282
PURE UUID: b05583be-b44b-490f-8b74-0c24e593b2d4
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Date deposited: 05 May 2022 16:55
Last modified: 17 Mar 2024 07:14
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