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Incidence of hip fracture in Saudi Arabia and the development of a FRAX model

Incidence of hip fracture in Saudi Arabia and the development of a FRAX model
Incidence of hip fracture in Saudi Arabia and the development of a FRAX model

A prospective hospital-based survey in representative regions of Saudi Arabia determined the incidence of fractures at the hip. The hip fracture rates were used to create a FRAX® model to facilitate fracture risk assessment in Saudi Arabia. OBJECTIVE: This paper describes the incidence of hip fracture in the Kingdom of Saudi Arabia that was used to characterize the current and future burden of hip fracture, to develop a country-specific FRAX® tool for fracture prediction and to compare fracture probabilities with neighbouring countries. METHODS: During a 2-year (2017/2018) prospective survey in 15 hospitals with a defined catchment population, hip fractures in Saudi citizens were prospectively identified from hospital registers. The number of hip fractures and future burden was determined from national demography. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Saudi Arabia. Fracture probabilities were compared with those from Kuwait and Abu Dhabi. RESULTS: The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 2,949 and is predicted to increase nearly sevenfold to 20,328 in 2050. Hip fracture rates were comparable with estimates from Abu Dhabi and Kuwait. By contrast, probabilities of a major osteoporotic fracture or hip fracture from the age of 70 years were much lower than those seen in Abu Dhabi and Kuwait due to higher mortality estimates for Saudi Arabia. CONCLUSION: A country-specific FRAX tool for fracture prediction has been developed for Saudi Arabia which is expected to help guide decisions about treatment.

FRAX, Fracture probability, Hip fracture, Osteoporosis epidemiology, Saudi Arabia
1862-3522
56
Al-Saleh, Yousef
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Sulimani, Riad
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Alomary, Shaker
bd526f1a-bb7c-49e1-8bfa-d88457ec74cd
Alnajjar, Yassmeen
19ce6609-8a94-474b-82ff-b3eda8ebb303
Vandenput, Liesbeth
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Liu, Enwu
08027c15-9e71-44bb-9623-3081f5f6492d
Lorentzon, Mattias
9d78ed25-2b0c-46c5-a2db-a8b246af0956
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Eugene, McCloskey
907f53ab-b84f-40f7-9718-3c34c3fc7916
Johansson, Helena
04f12338-4dd1-437b-b9bc-e0884130c215
Kanis, John A.
f1621d8d-8afb-4d97-9679-2165d88a344d
Saudi FRAX Study Group
Al-Saleh, Yousef
b6a30c8e-441b-418f-9c77-cf61799fd2b1
Sulimani, Riad
b53ee653-3b91-44db-be46-dd6ad0e7e7f7
Alomary, Shaker
bd526f1a-bb7c-49e1-8bfa-d88457ec74cd
Alnajjar, Yassmeen
19ce6609-8a94-474b-82ff-b3eda8ebb303
Vandenput, Liesbeth
0910d143-4b58-4579-82b0-3810272f1814
Liu, Enwu
08027c15-9e71-44bb-9623-3081f5f6492d
Lorentzon, Mattias
9d78ed25-2b0c-46c5-a2db-a8b246af0956
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Eugene, McCloskey
907f53ab-b84f-40f7-9718-3c34c3fc7916
Johansson, Helena
04f12338-4dd1-437b-b9bc-e0884130c215
Kanis, John A.
f1621d8d-8afb-4d97-9679-2165d88a344d

Al-Saleh, Yousef, Sulimani, Riad, Alomary, Shaker, Alnajjar, Yassmeen, Vandenput, Liesbeth, Liu, Enwu, Lorentzon, Mattias, Harvey, Nicholas, Eugene, McCloskey, Johansson, Helena and Kanis, John A. , Saudi FRAX Study Group (2022) Incidence of hip fracture in Saudi Arabia and the development of a FRAX model. Archives of Osteoporosis, 17 (1), 56, [56]. (doi:10.1007/s11657-022-01085-x).

Record type: Article

Abstract

A prospective hospital-based survey in representative regions of Saudi Arabia determined the incidence of fractures at the hip. The hip fracture rates were used to create a FRAX® model to facilitate fracture risk assessment in Saudi Arabia. OBJECTIVE: This paper describes the incidence of hip fracture in the Kingdom of Saudi Arabia that was used to characterize the current and future burden of hip fracture, to develop a country-specific FRAX® tool for fracture prediction and to compare fracture probabilities with neighbouring countries. METHODS: During a 2-year (2017/2018) prospective survey in 15 hospitals with a defined catchment population, hip fractures in Saudi citizens were prospectively identified from hospital registers. The number of hip fractures and future burden was determined from national demography. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Saudi Arabia. Fracture probabilities were compared with those from Kuwait and Abu Dhabi. RESULTS: The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 years for 2015 was 2,949 and is predicted to increase nearly sevenfold to 20,328 in 2050. Hip fracture rates were comparable with estimates from Abu Dhabi and Kuwait. By contrast, probabilities of a major osteoporotic fracture or hip fracture from the age of 70 years were much lower than those seen in Abu Dhabi and Kuwait due to higher mortality estimates for Saudi Arabia. CONCLUSION: A country-specific FRAX tool for fracture prediction has been developed for Saudi Arabia which is expected to help guide decisions about treatment.

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Saudi FRAX model report v4 OSIN R2 - Accepted Manuscript
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Accepted/In Press date: 23 February 2022
Published date: 2 April 2022
Keywords: FRAX, Fracture probability, Hip fracture, Osteoporosis epidemiology, Saudi Arabia

Identifiers

Local EPrints ID: 456620
URI: http://eprints.soton.ac.uk/id/eprint/456620
ISSN: 1862-3522
PURE UUID: fada7b8c-ced6-41aa-aed7-6a637379e37c
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

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Date deposited: 05 May 2022 16:56
Last modified: 26 Nov 2022 02:39

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Contributors

Author: Yousef Al-Saleh
Author: Riad Sulimani
Author: Shaker Alomary
Author: Yassmeen Alnajjar
Author: Liesbeth Vandenput
Author: Enwu Liu
Author: Mattias Lorentzon
Author: Nicholas Harvey ORCID iD
Author: McCloskey Eugene
Author: Helena Johansson
Author: John A. Kanis
Corporate Author: Saudi FRAX Study Group

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