Medical history, medication use and physical activity in adults in their eighth and ninth decade of life in the Hertfordshire Cohort Study
Medical history, medication use and physical activity in adults in their eighth and ninth decade of life in the Hertfordshire Cohort Study
While there are many known health benefits to maintained physical activity levels in late adulthood, there have been very few studies that have considered relationships between morbidity profile and physical activity in the eighth decade of life. We studied 1097 participants, 555 men and 542 women from the Hertfordshire Cohort Study, a UK community based sample. Validated questionnaire based data were used to relate self-reported physical activity (PA) levels to medical history, and medication use. Regression analyses were adjusted for age, BMI, smoker status, alcohol consumption. The mean (SD) age of participants in the study was 80.2 (2.7) years for men and 80.2 (2.6) for women. A higher proportion of men (33.7 %) than women (24 %) were in the high activity score group. 20.8 % of female participants and 22.6 % male participants reported having no comorbid disease; 10.5 % men and 8.4 % women were taking no medication. Higher number of chronic conditions was associated with lower levels of PA [men (OR 0.73, 95 % CI 0.63-0.84, p<0.001); women (OR 0.74, 95 % CI 0.64-0.86, p<0.001)] as was being prescribed a higher number of medications [men (OR 0.88, 95 % CI 0.84-0.93, p<0.001); women (OR 0.86, 95 % CI 0.82-0.91, p<0.001)]. All these associations remained robust following adjustments. Strong relationships were seen in both sexes between PA and taking medication for disorders of the central nervous system and gastrointestinal system, with relationships generally stronger in men. We have observed relationships between comorbid medical history and medication use with physical activity in a cohort of community dwelling older adults. These highlight the need to consider medical history when considering how best to optimize PA in older adults.
Older, activity, comorbidity, medication, system
695-703
Bevilacqua, Gregorio
e93e3b18-7d1e-4da5-9fcd-e6b4637e1c2e
Zhang, Jean
437abe90-46ac-46de-8183-042c36ed3398
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Laskou, Faidra
3959d6e2-ccfa-4d97-8311-16f27b893365
Fuggle, Nicholas
9ab0c81a-ac67-41c4-8860-23e0fdb1a900
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
18 April 2022
Bevilacqua, Gregorio
e93e3b18-7d1e-4da5-9fcd-e6b4637e1c2e
Zhang, Jean
437abe90-46ac-46de-8183-042c36ed3398
Parsons, Camille
9730e5c3-0382-4ed7-8eaa-6932ab09ec15
Laskou, Faidra
3959d6e2-ccfa-4d97-8311-16f27b893365
Fuggle, Nicholas
9ab0c81a-ac67-41c4-8860-23e0fdb1a900
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Bevilacqua, Gregorio, Zhang, Jean, Parsons, Camille, Laskou, Faidra, Fuggle, Nicholas, Cooper, Cyrus and Dennison, Elaine
(2022)
Medical history, medication use and physical activity in adults in their eighth and ninth decade of life in the Hertfordshire Cohort Study.
Experimental & Clinical Sciences Journal, 21, .
(doi:10.17179/excli2022-4874).
Abstract
While there are many known health benefits to maintained physical activity levels in late adulthood, there have been very few studies that have considered relationships between morbidity profile and physical activity in the eighth decade of life. We studied 1097 participants, 555 men and 542 women from the Hertfordshire Cohort Study, a UK community based sample. Validated questionnaire based data were used to relate self-reported physical activity (PA) levels to medical history, and medication use. Regression analyses were adjusted for age, BMI, smoker status, alcohol consumption. The mean (SD) age of participants in the study was 80.2 (2.7) years for men and 80.2 (2.6) for women. A higher proportion of men (33.7 %) than women (24 %) were in the high activity score group. 20.8 % of female participants and 22.6 % male participants reported having no comorbid disease; 10.5 % men and 8.4 % women were taking no medication. Higher number of chronic conditions was associated with lower levels of PA [men (OR 0.73, 95 % CI 0.63-0.84, p<0.001); women (OR 0.74, 95 % CI 0.64-0.86, p<0.001)] as was being prescribed a higher number of medications [men (OR 0.88, 95 % CI 0.84-0.93, p<0.001); women (OR 0.86, 95 % CI 0.82-0.91, p<0.001)]. All these associations remained robust following adjustments. Strong relationships were seen in both sexes between PA and taking medication for disorders of the central nervous system and gastrointestinal system, with relationships generally stronger in men. We have observed relationships between comorbid medical history and medication use with physical activity in a cohort of community dwelling older adults. These highlight the need to consider medical history when considering how best to optimize PA in older adults.
Text
4874-Article Text
- Accepted Manuscript
More information
Accepted/In Press date: 12 April 2022
e-pub ahead of print date: 18 April 2022
Published date: 18 April 2022
Additional Information:
Funding Information:
Professor Cyrus Cooper has received lecture fees and honoraria from Amgen, Danone, Eli Lilly, GSK, Kyowa Kirin, Medtronic, Merck, Nestlé, Novartis, Pfizer, Roche, Servier, Shire, Takeda and UCB outside of the submitted work. Drs. Faidra Laskou and Jean Zhang are supported by the NIHR Southampton Biomedical Research Centre, and the University of Southampton. Professor Elaine Dennison has received lecture fees and honoraria from UCB, Pfizer, Lilly and Viatris outside of the submitted work. Dr. Nicholas Fug-gle has received travel and educational bursaries from Pfizer and Lilly. Drs. Gregorio Bevilacqua and Millie Parsons declare no conflicts of interest.
Funding Information:
We thank the Hertfordshire Cohort study participants who made this work possible. This work was funded by the Medical Research Council. FL and JZ are supported by the NIHR Southampton Biomedical Research Centre, and the University of Southampton.
Publisher Copyright:
© 2022, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
Keywords:
Older, activity, comorbidity, medication, system
Identifiers
Local EPrints ID: 457641
URI: http://eprints.soton.ac.uk/id/eprint/457641
PURE UUID: 1c6585ed-3996-453f-a69d-16d171070d3f
Catalogue record
Date deposited: 14 Jun 2022 16:50
Last modified: 18 Mar 2024 05:10
Export record
Altmetrics
Contributors
Author:
Gregorio Bevilacqua
Author:
Jean Zhang
Author:
Camille Parsons
Author:
Faidra Laskou
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics