The synthesis and application of novel resins and solid supported reagents
The synthesis and application of novel resins and solid supported reagents
The aims of this project were the synthesize new PS-based resins and investigate their properties with respect to cross-linking by application to organic and peptide chemistry, and also to investigate the synthesis of novel resin-bound reagents.
A range of PS-DVB resins was synthesized by suspension polymerization and yields a reaction and swelling properties measured as a function of cross-linking. The first synthesis of the natural product Kawaguchipeptin B was performed on each resin and the relationship between purity and cross-linking investigated. The Suzuki reaction was performed and the rate of formation of a biaryl compound on the resins then investigated as a function of cross-linking.
The synthesis of a paramagnetic resin by novel suspension polymerisation methods was demonstrated and the resin applied to the field of reaction scavenging.
The synthesis of a novel PS-DVB-imidazole and PS-DVB-isocyanate resin was carried out and their utilities in reaction catalysis and scavenging investigated.
University of Southampton
Rana, Sunil
16726f81-3e09-45e4-b07b-944e7679e8ca
2001
Rana, Sunil
16726f81-3e09-45e4-b07b-944e7679e8ca
Rana, Sunil
(2001)
The synthesis and application of novel resins and solid supported reagents.
University of Southampton, Doctoral Thesis.
Record type:
Thesis
(Doctoral)
Abstract
The aims of this project were the synthesize new PS-based resins and investigate their properties with respect to cross-linking by application to organic and peptide chemistry, and also to investigate the synthesis of novel resin-bound reagents.
A range of PS-DVB resins was synthesized by suspension polymerization and yields a reaction and swelling properties measured as a function of cross-linking. The first synthesis of the natural product Kawaguchipeptin B was performed on each resin and the relationship between purity and cross-linking investigated. The Suzuki reaction was performed and the rate of formation of a biaryl compound on the resins then investigated as a function of cross-linking.
The synthesis of a paramagnetic resin by novel suspension polymerisation methods was demonstrated and the resin applied to the field of reaction scavenging.
The synthesis of a novel PS-DVB-imidazole and PS-DVB-isocyanate resin was carried out and their utilities in reaction catalysis and scavenging investigated.
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Published date: 2001
Identifiers
Local EPrints ID: 464335
URI: http://eprints.soton.ac.uk/id/eprint/464335
PURE UUID: 651ec6d7-9ec7-4bb0-895b-50e75a5ee282
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Date deposited: 04 Jul 2022 22:18
Last modified: 16 Mar 2024 19:25
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Author:
Sunil Rana
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