Zonulin and blood-brain barrier permeability are dissociated in humans
Zonulin and blood-brain barrier permeability are dissociated in humans
Zonulin regulates intestinal epithelial tight junctions but its role in blood-brain barrier permeability in humans is unclear.
Three techniques were utilized to assess blood-brain barrier permeability: dynamic contrast-enhanced magnetic resonance imaging, cerebrospinal fluid / serum albumin quotient and fluorescent dextrans in a human cerebrovascular endothelial cell line.
Zonulin did not correlate with blood-brain barrier permeability in vivo or in vitro.
blood-brain barrier, haptoglobin, permeability, zonulin
e965
Stuart, Charlotte M
734d13d9-fd1f-4c55-ba90-bf1abf303bb4
Varatharaj, Aravinthan
33d833af-9459-4b21-8489-ce9c0b6a09e0
Winberg, Martin E.
e670daa3-1063-4aba-b294-ce200d72c74b
Galea, Pascale
8fdf18e7-7b22-4bb7-aac9-9a51fc1b22b2
Larsson, Henrik B.W.
e6a4213a-310b-4928-8f07-4e2e53be51ae
Cramer, Stig P.
ed3fe479-8e5e-4e38-bc02-bac30263db63
Fasano, Alessio
8cdd7259-3b8e-4597-8ebb-ef24e258774b
Maherally, Zaynah
7cbfb6ae-a6bc-462f-b005-884cfa42c9cf
Pilkington, Geoffrey J.
c61b55d2-41d3-46e9-96ee-48a82e1abb0d
Keita, Åsa V
0eea0dcf-e282-4211-a8ca-94f454bf506c
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
July 2022
Stuart, Charlotte M
734d13d9-fd1f-4c55-ba90-bf1abf303bb4
Varatharaj, Aravinthan
33d833af-9459-4b21-8489-ce9c0b6a09e0
Winberg, Martin E.
e670daa3-1063-4aba-b294-ce200d72c74b
Galea, Pascale
8fdf18e7-7b22-4bb7-aac9-9a51fc1b22b2
Larsson, Henrik B.W.
e6a4213a-310b-4928-8f07-4e2e53be51ae
Cramer, Stig P.
ed3fe479-8e5e-4e38-bc02-bac30263db63
Fasano, Alessio
8cdd7259-3b8e-4597-8ebb-ef24e258774b
Maherally, Zaynah
7cbfb6ae-a6bc-462f-b005-884cfa42c9cf
Pilkington, Geoffrey J.
c61b55d2-41d3-46e9-96ee-48a82e1abb0d
Keita, Åsa V
0eea0dcf-e282-4211-a8ca-94f454bf506c
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Stuart, Charlotte M, Varatharaj, Aravinthan, Winberg, Martin E., Galea, Pascale, Larsson, Henrik B.W., Cramer, Stig P., Fasano, Alessio, Maherally, Zaynah, Pilkington, Geoffrey J., Keita, Åsa V and Galea, Ian
(2022)
Zonulin and blood-brain barrier permeability are dissociated in humans.
Clinical and Translational Medicine, 12 (7), .
(doi:10.1002/ctm2.965).
Abstract
Zonulin regulates intestinal epithelial tight junctions but its role in blood-brain barrier permeability in humans is unclear.
Three techniques were utilized to assess blood-brain barrier permeability: dynamic contrast-enhanced magnetic resonance imaging, cerebrospinal fluid / serum albumin quotient and fluorescent dextrans in a human cerebrovascular endothelial cell line.
Zonulin did not correlate with blood-brain barrier permeability in vivo or in vitro.
Text
Stuart et al 2022 postprint
- Accepted Manuscript
Text
Clinical Translational Med - 2022 - Stuart - Zonulin and blood brain barrier permeability are dissociated in humans
- Version of Record
More information
Accepted/In Press date: 20 June 2022
e-pub ahead of print date: 8 July 2022
Published date: July 2022
Keywords:
blood-brain barrier, haptoglobin, permeability, zonulin
Identifiers
Local EPrints ID: 467973
URI: http://eprints.soton.ac.uk/id/eprint/467973
ISSN: 2001-1326
PURE UUID: 739cc666-a3b9-4930-8975-3c785d5f78a7
Catalogue record
Date deposited: 26 Jul 2022 17:19
Last modified: 17 Mar 2024 03:53
Export record
Altmetrics
Contributors
Author:
Charlotte M Stuart
Author:
Martin E. Winberg
Author:
Pascale Galea
Author:
Henrik B.W. Larsson
Author:
Stig P. Cramer
Author:
Alessio Fasano
Author:
Zaynah Maherally
Author:
Geoffrey J. Pilkington
Author:
Åsa V Keita
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics