The University of Southampton
University of Southampton Institutional Repository

Zonulin and blood-brain barrier permeability are dissociated in humans

Zonulin and blood-brain barrier permeability are dissociated in humans
Zonulin and blood-brain barrier permeability are dissociated in humans
Zonulin regulates intestinal epithelial tight junctions but its role in blood-brain barrier permeability in humans is unclear.

Three techniques were utilized to assess blood-brain barrier permeability: dynamic contrast-enhanced magnetic resonance imaging, cerebrospinal fluid / serum albumin quotient and fluorescent dextrans in a human cerebrovascular endothelial cell line.

Zonulin did not correlate with blood-brain barrier permeability in vivo or in vitro.
blood-brain barrier, haptoglobin, permeability, zonulin
2001-1326
e965
Stuart, Charlotte M
734d13d9-fd1f-4c55-ba90-bf1abf303bb4
Varatharaj, Aravinthan
33d833af-9459-4b21-8489-ce9c0b6a09e0
Winberg, Martin E.
e670daa3-1063-4aba-b294-ce200d72c74b
Galea, Pascale
8fdf18e7-7b22-4bb7-aac9-9a51fc1b22b2
Larsson, Henrik B.W.
e6a4213a-310b-4928-8f07-4e2e53be51ae
Cramer, Stig P.
ed3fe479-8e5e-4e38-bc02-bac30263db63
Fasano, Alessio
8cdd7259-3b8e-4597-8ebb-ef24e258774b
Maherally, Zaynah
7cbfb6ae-a6bc-462f-b005-884cfa42c9cf
Pilkington, Geoffrey J.
c61b55d2-41d3-46e9-96ee-48a82e1abb0d
Keita, Åsa V
0eea0dcf-e282-4211-a8ca-94f454bf506c
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Stuart, Charlotte M
734d13d9-fd1f-4c55-ba90-bf1abf303bb4
Varatharaj, Aravinthan
33d833af-9459-4b21-8489-ce9c0b6a09e0
Winberg, Martin E.
e670daa3-1063-4aba-b294-ce200d72c74b
Galea, Pascale
8fdf18e7-7b22-4bb7-aac9-9a51fc1b22b2
Larsson, Henrik B.W.
e6a4213a-310b-4928-8f07-4e2e53be51ae
Cramer, Stig P.
ed3fe479-8e5e-4e38-bc02-bac30263db63
Fasano, Alessio
8cdd7259-3b8e-4597-8ebb-ef24e258774b
Maherally, Zaynah
7cbfb6ae-a6bc-462f-b005-884cfa42c9cf
Pilkington, Geoffrey J.
c61b55d2-41d3-46e9-96ee-48a82e1abb0d
Keita, Åsa V
0eea0dcf-e282-4211-a8ca-94f454bf506c
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b

Stuart, Charlotte M, Varatharaj, Aravinthan, Winberg, Martin E., Galea, Pascale, Larsson, Henrik B.W., Cramer, Stig P., Fasano, Alessio, Maherally, Zaynah, Pilkington, Geoffrey J., Keita, Åsa V and Galea, Ian (2022) Zonulin and blood-brain barrier permeability are dissociated in humans. Clinical and Translational Medicine, 12 (7), e965. (doi:10.1002/ctm2.965).

Record type: Article

Abstract

Zonulin regulates intestinal epithelial tight junctions but its role in blood-brain barrier permeability in humans is unclear.

Three techniques were utilized to assess blood-brain barrier permeability: dynamic contrast-enhanced magnetic resonance imaging, cerebrospinal fluid / serum albumin quotient and fluorescent dextrans in a human cerebrovascular endothelial cell line.

Zonulin did not correlate with blood-brain barrier permeability in vivo or in vitro.

Text
Stuart et al 2022 postprint - Accepted Manuscript
Available under License Creative Commons Attribution.
Download (492kB)
Text
Clinical Translational Med - 2022 - Stuart - Zonulin and blood brain barrier permeability are dissociated in humans - Version of Record
Available under License Creative Commons Attribution.
Download (736kB)

More information

Accepted/In Press date: 20 June 2022
e-pub ahead of print date: 8 July 2022
Published date: July 2022
Keywords: blood-brain barrier, haptoglobin, permeability, zonulin

Identifiers

Local EPrints ID: 467973
URI: http://eprints.soton.ac.uk/id/eprint/467973
ISSN: 2001-1326
PURE UUID: 739cc666-a3b9-4930-8975-3c785d5f78a7
ORCID for Charlotte M Stuart: ORCID iD orcid.org/0000-0002-5779-5487
ORCID for Aravinthan Varatharaj: ORCID iD orcid.org/0000-0003-1629-5774
ORCID for Ian Galea: ORCID iD orcid.org/0000-0002-1268-5102

Catalogue record

Date deposited: 26 Jul 2022 17:19
Last modified: 17 Mar 2024 03:53

Export record

Altmetrics

Contributors

Author: Charlotte M Stuart ORCID iD
Author: Martin E. Winberg
Author: Pascale Galea
Author: Henrik B.W. Larsson
Author: Stig P. Cramer
Author: Alessio Fasano
Author: Zaynah Maherally
Author: Geoffrey J. Pilkington
Author: Åsa V Keita
Author: Ian Galea ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×