Dataset to support the Southampton Doctoral thesis entitled 'Novel approaches to discovering inhibitors of essential bacterial enzymes'

Abstract

Biochemical data collected in support of thesis entitled 'Novel Approaches to Discovering Inhibitors of Essential Bacterial Enzymes'. Comprises: - Melting analysis of truncated tRNA with MBG1 (Figure 2.5.2) - Obtained using a Lightcycler 1.5, see methods 9.4.7. Date collected 19-09-16 - Melting analysis of tRNALeuUAG with MBG1 (Figure 3.4.2) - Obtained using a BioRad CFX touch, see methods 9.5.8. Date collected 02-08-18 - Optimization of DH and MBG1 concentrations (Figure 3.4.4) - Obtained using a BMG plate reader, see methods 9.5.10. Date collected 20-11-18 - Optimized time course (Figure 4.2.2) - Obtained using a BMG plate reader, see methods 9.6.2. Date collected 12-06-17 - Km of SAM (Figure 4.2.4) - Obtained using a BMG plate reader, see methods 9.6.5. Date collected 28-11-18 - Inhibitor Assay screen (Figure 4.4.4) - Obtained using a BMG plate reader, see methods 9.6.5. Date collected 10-12-18 - HPLC validation (Figure 4.3.7) -See methods 9.6.3. Date collected 11-12-18

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