Osteoarthritis: The importance of hormonal status in midlife women
Osteoarthritis: The importance of hormonal status in midlife women
Osteoarthritis (OA) is the commonest joint condition globally, affecting 18 % of women over the age of 60 years, although the prevalence varies according to the definition used. Although it may develop in any joint, it most commonly affects joints of the knee, hip, hand, spine and foot. Because OA often emerges in women in midlife, there has been longstanding interest in the association between hormonal status and the development and progression of OA. Researchers have variably suggested that estrogen exposure may be a risk factor for OA development, or that, conversely, it may be used as a therapy to treat OA. This review considers the historical development of this question, first described in the literature in 1805, and highlights the need for future research in this area.
Epidemiology, Estrogen, Hormone, Menopause, Osteoarthritis
8-11
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
November 2022
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Abstract
Osteoarthritis (OA) is the commonest joint condition globally, affecting 18 % of women over the age of 60 years, although the prevalence varies according to the definition used. Although it may develop in any joint, it most commonly affects joints of the knee, hip, hand, spine and foot. Because OA often emerges in women in midlife, there has been longstanding interest in the association between hormonal status and the development and progression of OA. Researchers have variably suggested that estrogen exposure may be a risk factor for OA development, or that, conversely, it may be used as a therapy to treat OA. This review considers the historical development of this question, first described in the literature in 1805, and highlights the need for future research in this area.
Text
Maturitas 2022 OA menopause final revised 1
- Accepted Manuscript
Text
1-s2.0-S037851222200144X-main (1)
- Version of Record
More information
Accepted/In Press date: 2 June 2022
e-pub ahead of print date: 11 July 2022
Published date: November 2022
Additional Information:
Publisher Copyright:
© 2022 The Author(s)
Keywords:
Epidemiology, Estrogen, Hormone, Menopause, Osteoarthritis
Identifiers
Local EPrints ID: 468586
URI: http://eprints.soton.ac.uk/id/eprint/468586
ISSN: 0378-5122
PURE UUID: 7417ca28-8a11-4bfc-9637-6809a90dc8bb
Catalogue record
Date deposited: 18 Aug 2022 16:41
Last modified: 06 Jun 2024 04:14
Export record
Altmetrics
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
