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Osteoarthritis: The importance of hormonal status in midlife women

Osteoarthritis: The importance of hormonal status in midlife women
Osteoarthritis: The importance of hormonal status in midlife women
Osteoarthritis (OA) is the commonest joint condition globally, affecting 18 % of women over the age of 60 years, although the prevalence varies according to the definition used. Although it may develop in any joint, it most commonly affects joints of the knee, hip, hand, spine and foot. Because OA often emerges in women in midlife, there has been longstanding interest in the association between hormonal status and the development and progression of OA. Researchers have variably suggested that estrogen exposure may be a risk factor for OA development, or that, conversely, it may be used as a therapy to treat OA. This review considers the historical development of this question, first described in the literature in 1805, and highlights the need for future research in this area.
0378-5122
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1

Dennison, Elaine (2022) Osteoarthritis: The importance of hormonal status in midlife women. Maturitas, 165. (doi:10.1016/j.maturitas.2022.07.002).

Record type: Article

Abstract

Osteoarthritis (OA) is the commonest joint condition globally, affecting 18 % of women over the age of 60 years, although the prevalence varies according to the definition used. Although it may develop in any joint, it most commonly affects joints of the knee, hip, hand, spine and foot. Because OA often emerges in women in midlife, there has been longstanding interest in the association between hormonal status and the development and progression of OA. Researchers have variably suggested that estrogen exposure may be a risk factor for OA development, or that, conversely, it may be used as a therapy to treat OA. This review considers the historical development of this question, first described in the literature in 1805, and highlights the need for future research in this area.

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Maturitas 2022 OA menopause final revised 1 - Accepted Manuscript
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Accepted/In Press date: 2 June 2022
e-pub ahead of print date: 11 July 2022

Identifiers

Local EPrints ID: 468586
URI: http://eprints.soton.ac.uk/id/eprint/468586
ISSN: 0378-5122
PURE UUID: 7417ca28-8a11-4bfc-9637-6809a90dc8bb
ORCID for Elaine Dennison: ORCID iD orcid.org/0000-0002-3048-4961

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Date deposited: 18 Aug 2022 16:41
Last modified: 19 Aug 2022 01:34

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