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Polyunsaturated fatty acids and metabolic health: novel insights

Polyunsaturated fatty acids and metabolic health: novel insights
Polyunsaturated fatty acids and metabolic health: novel insights

Purpose of review
This review aims to discuss the potential roles of omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) in the prevention and treatment of metabolic diseases, to provide the latest evidence from epidemiological and clinical studies, and to highlight novel insights into this field.

Recent findings
Higher dietary or circulating ω-3 PUFA levels are related to a lower risk of metabolic syndrome. Novel findings in obesity indicate higher proportions of ω-6 and ω-3 PUFAs, a modulated oxylipin profile and an altered transcriptome in subcutaneous white adipose tissue, that seem resistant to the effects of ω-3 PUFAs compared with what occurs in normal weight individuals. ω-3 PUFAs may improve the blood lipid profile and glycemic outcomes in patients with type 2 diabetes mellitus and reduce liver fat in nonalcoholic fatty liver disease (NAFLD); the findings of several recent meta-analyses support these effects. Genetic background affects inter-individual variability in the insulin sensitivity response to ω-3 PUFA supplementation. ω-3 PUFAs have prebiotic effects, altering the gut microbiota.

Summary
Although evidence for health benefits of ω-3 PUFAs is strong, recent findings suggest a more personalized approach to ω-3 PUFA intake for individuals at high risk for metabolic diseases.
1363-1950
Djuricic, Ivana
e4c91f46-aadf-42d6-abe2-736ba00be71b
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Djuricic, Ivana
e4c91f46-aadf-42d6-abe2-736ba00be71b
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6

Djuricic, Ivana and Calder, Philip (2022) Polyunsaturated fatty acids and metabolic health: novel insights. Current Opinion in Clinical Nutrition and Metabolic Care. (doi:10.1097/MCO.0000000000000865).

Record type: Review

Abstract


Purpose of review
This review aims to discuss the potential roles of omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) in the prevention and treatment of metabolic diseases, to provide the latest evidence from epidemiological and clinical studies, and to highlight novel insights into this field.

Recent findings
Higher dietary or circulating ω-3 PUFA levels are related to a lower risk of metabolic syndrome. Novel findings in obesity indicate higher proportions of ω-6 and ω-3 PUFAs, a modulated oxylipin profile and an altered transcriptome in subcutaneous white adipose tissue, that seem resistant to the effects of ω-3 PUFAs compared with what occurs in normal weight individuals. ω-3 PUFAs may improve the blood lipid profile and glycemic outcomes in patients with type 2 diabetes mellitus and reduce liver fat in nonalcoholic fatty liver disease (NAFLD); the findings of several recent meta-analyses support these effects. Genetic background affects inter-individual variability in the insulin sensitivity response to ω-3 PUFA supplementation. ω-3 PUFAs have prebiotic effects, altering the gut microbiota.

Summary
Although evidence for health benefits of ω-3 PUFAs is strong, recent findings suggest a more personalized approach to ω-3 PUFA intake for individuals at high risk for metabolic diseases.

Text
Djuricic and Calder_COCN_Revised - Accepted Manuscript
Restricted to Repository staff only until 18 July 2023.
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Text
Polyunsaturated_fatty_acids_and_metabolic_health_.22 - Version of Record
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More information

Accepted/In Press date: 18 July 2022
e-pub ahead of print date: 10 August 2022

Identifiers

Local EPrints ID: 468615
URI: http://eprints.soton.ac.uk/id/eprint/468615
ISSN: 1363-1950
PURE UUID: fbec0546-ce2c-40b7-ae9f-4bf475302378
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 18 Aug 2022 17:07
Last modified: 20 Aug 2022 01:34

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Contributors

Author: Ivana Djuricic
Author: Philip Calder ORCID iD

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