Quality of life and health status in older adults (≥65 years) up to five years following colorectal cancer treatment: Findings from the ColoREctal Wellbeing (CREW) cohort study
Quality of life and health status in older adults (≥65 years) up to five years following colorectal cancer treatment: Findings from the ColoREctal Wellbeing (CREW) cohort study
Objective Colorectal cancer (CRC) is common in older adults, with more than 70% of diagnoses in people aged ≥65 years. Despite this, there is a knowledge gap regarding longer-term outcomes in this population. Here, we identify those older people most at risk of poor quality of life (QoL) and health status in the five years following CRC treatment. Materials and methods CREW is a UK longitudinal cohort study investigating factors associated with health and wellbeing recovery following curative-intent CRC surgery. Participants completed self-report questionnaires pre-surgery, then at least annually up to five years. Longitudinal analyses explored the prevalence and pre-surgery risk factors of poor QoL (QLACS-GSS) and health status (EQ-5D: presence/absence of problems in five domains) in older (≥65 years) participants over five years. Results 501 participants aged ≥65years completed questionnaires pre-surgery; 45% completed questionnaires five years later. Oldest-old participants (≥80 years) reported poorer QoL (18% higher QLACS-GSS) and 2–4 times higher odds of having problems with mobility or usual activities, compared with the youngest-old (65–69 years) over follow-up. Baseline higher self-efficacy was significantly associated with better QoL (10–30% lower QLACS-GSS scores compared to those with low self-efficacy) and lower odds of problems in all EQ-5D domains. Adequate social support was significantly associated with better QoL (8% lower QLACS-GSS) and lower odds of problems with usual activities (OR = 0.62) and anxiety/depression (OR = 0.56). Conclusion There are important differences in QoL and health status outcomes for the oldest-old during CRC recovery. CREW reveals pre-surgery risk factors that are amenable to intervention including self-efficacy and social support.
Cummings, Amanda
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Foster, Rebecca
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Calman, Lynn
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Permyakova, Natalia V.
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Bridges, Jackie
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Wiseman, Theresa
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Corbett, Teresa
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Smith, Peter W. F.
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Foster, Claire
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Kardeş, Sinan
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14 July 2022
Cummings, Amanda
7c5f6bd2-979b-456d-9368-8edd13c06691
Foster, Rebecca
74f75d51-0db1-4044-bd77-3ab87e6846ff
Calman, Lynn
9ae254eb-74a7-4906-9eb4-62ad99f058c1
Permyakova, Natalia V.
f72b4f3b-d27e-4e64-ab46-298f312affdf
Bridges, Jackie
57e80ebe-ee5f-4219-9bbc-43215e8363cd
Wiseman, Theresa
e3ff42ae-97ef-4640-af3d-40eeae830df9
Corbett, Teresa
bce81837-17ae-46c3-a6b1-43a7e1f07f9c
Smith, Peter W. F.
961a01a3-bf4c-43ca-9599-5be4fd5d3940
Foster, Claire
00786ac1-bd47-4aeb-a0e2-40e058695b73
Kardeş, Sinan
af5db3db-2036-4808-a4a6-f11af69b58c7
Cummings, Amanda, Foster, Rebecca, Calman, Lynn, Permyakova, Natalia V., Bridges, Jackie, Wiseman, Theresa, Corbett, Teresa, Smith, Peter W. F. and Foster, Claire
,
Kardeş, Sinan
(ed.)
(2022)
Quality of life and health status in older adults (≥65 years) up to five years following colorectal cancer treatment: Findings from the ColoREctal Wellbeing (CREW) cohort study.
PLoS ONE, 17 (7), [e0270033].
(doi:10.1371/journal.pone.0270033).
Abstract
Objective Colorectal cancer (CRC) is common in older adults, with more than 70% of diagnoses in people aged ≥65 years. Despite this, there is a knowledge gap regarding longer-term outcomes in this population. Here, we identify those older people most at risk of poor quality of life (QoL) and health status in the five years following CRC treatment. Materials and methods CREW is a UK longitudinal cohort study investigating factors associated with health and wellbeing recovery following curative-intent CRC surgery. Participants completed self-report questionnaires pre-surgery, then at least annually up to five years. Longitudinal analyses explored the prevalence and pre-surgery risk factors of poor QoL (QLACS-GSS) and health status (EQ-5D: presence/absence of problems in five domains) in older (≥65 years) participants over five years. Results 501 participants aged ≥65years completed questionnaires pre-surgery; 45% completed questionnaires five years later. Oldest-old participants (≥80 years) reported poorer QoL (18% higher QLACS-GSS) and 2–4 times higher odds of having problems with mobility or usual activities, compared with the youngest-old (65–69 years) over follow-up. Baseline higher self-efficacy was significantly associated with better QoL (10–30% lower QLACS-GSS scores compared to those with low self-efficacy) and lower odds of problems in all EQ-5D domains. Adequate social support was significantly associated with better QoL (8% lower QLACS-GSS) and lower odds of problems with usual activities (OR = 0.62) and anxiety/depression (OR = 0.56). Conclusion There are important differences in QoL and health status outcomes for the oldest-old during CRC recovery. CREW reveals pre-surgery risk factors that are amenable to intervention including self-efficacy and social support.
Text
journal.pone.0270033
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Quality of life and health status in older adults (65 years) up to five years following colorectal cancer treatment
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Accepted/In Press date: 6 July 2022
Published date: 14 July 2022
Additional Information:
Funding Information:
The ColoREctal Well-being (CREW) study is funded by Macmillan Cancer Support grant number 3546834. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank all CREW study participants and recruiting NHS Trusts; Carol Hill, Kerry Coleman, Bjoern Schukowsky, Christine May (study support); Matthew Breckons, Cassandra Powers, Alex Recio-Saucedo, Bina Nausheen, Ikumi Okamoto, Kim-Chivers Seymour, Joanne Haviland (researchers); Jo Clough, Alison Farmer (research partners). Members of the Study Advisory Committee: Jo Armes, Janis Baird, Andrew Bateman, Nick Beck, Graham Moon, Claire Hulme, Peter Hall, Karen Poole, Susan Restorick-Banks, Paul Roderick, Claire Taylor, Jocelyn Walters, Fran Williams, Lynn Batehup, Jessica Corner, and Deborah Fenlon.
Publisher Copyright:
© 2022 Cummings et al.
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Local EPrints ID: 468899
URI: http://eprints.soton.ac.uk/id/eprint/468899
ISSN: 1932-6203
PURE UUID: e498e9e8-f097-48ad-8d66-5c39f8688f39
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Date deposited: 31 Aug 2022 16:56
Last modified: 17 Mar 2024 07:26
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Author:
Natalia V. Permyakova
Author:
Theresa Wiseman
Author:
Teresa Corbett
Editor:
Sinan Kardeş
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