Perinatal plasma carotenoid and vitamin E concentrations with maternal blood pressure during and after pregnancy.
Perinatal plasma carotenoid and vitamin E concentrations with maternal blood pressure during and after pregnancy.
Background and aims: Few studies examined the influence of carotenoids and vitamin E on blood pressure or hypertension during and after pregnancy. We related perinatal plasma concentrations of carotenoids and vitamin E (in individual forms and in combination) to blood pressure and hypertension at late pregnancy and 4 years post-pregnancy. Methods and results: In 684 women of the Growing Up in Singapore Towards Healthy Outcomes cohort, we quantified plasma carotenoids and vitamin E concentrations at delivery. Systolic blood pressure and diastolic blood pressure (SBP and DBP) around 37–39 weeks’ gestation were extracted from obstetric records and measured at 4 years post-pregnancy. Principal component analysis derived patterns of carotenoids (CP) and vitamin E. Associations were examined using linear or logistic regressions adjusting for confounders. Two carotenoids (CP1: α-carotene, β-carotene, and lutein; CP2: zeaxanthin, lycopene, and β-cryptoxanthin) and one vitamin E (γ-, δ-, and α-tocopherols) patterns were derived. CP1 (1SD score increment) was associated with lower SBP and DBP [β (95% CI): −2.36 (−3.47, −1.26) and −1.37 (−2.21, −0.53) mmHg] at late pregnancy> and 4 years post-pregnancy [-1.45 (−2.72, −0.18) and −0.99 (−1.98, −0.01) mmHg]. Higher β-cryptoxanthin concentrations were associated with lower SBP and DBP [-1.50 (−2.49, −0.51) and −1.20 (−1.95, −0.46) mmHg] at late pregnancy. Individual vitamin E and their pattern were not associated with blood pressure or hypertension. Conclusion: Higher perinatal α-carotene, β-carotene, and lutein concentrations are associated with lower blood pressure in women at late pregnancy and post-pregnancy. Foods rich in these carotenoids, such as red-, orange-, and dark-green-colored vegetables, might be beneficial for blood pressure during and after pregnancy.
Blood pressure, Carotenoids, Post-pregnancy, Pregnancy, Vitamin E
2811-2821
Lai, Jun S.
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Yuan, Wen Lun
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Ong, Choon Nam
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Tan, Kok Hian
4714c94d-334a-42ad-b879-f3aa3a931def
Yap, Fabian
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Chong, Yap-Seng
7043124b-e892-4d4b-8bb7-6d35ed94e136
Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Lee, Yung Seng
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Chan, Jerry K.Y.
02be1a7b-b6bc-43e5-b195-0f0253f60afb
Chan, Shiao-Yng
3c9d8970-2cc4-430a-86a7-96f6029a5293
Chong, Mary F.F.
1e188259-b1ab-4448-9e65-5b6a0fd99502
December 2022
Lai, Jun S.
1fd69464-147f-4220-ab67-f9d76437cf3b
Yuan, Wen Lun
ecbeb304-07b2-4a41-a535-e8bb4e31881d
Ong, Choon Nam
29ad2936-dbb8-45c6-8455-03abf5ca757a
Tan, Kok Hian
4714c94d-334a-42ad-b879-f3aa3a931def
Yap, Fabian
22f6b954-31fc-4696-a52b-e985a424b95b
Chong, Yap-Seng
7043124b-e892-4d4b-8bb7-6d35ed94e136
Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Lee, Yung Seng
0e28a8d6-3085-4086-9fa1-ac0684783bcf
Chan, Jerry K.Y.
02be1a7b-b6bc-43e5-b195-0f0253f60afb
Chan, Shiao-Yng
3c9d8970-2cc4-430a-86a7-96f6029a5293
Chong, Mary F.F.
1e188259-b1ab-4448-9e65-5b6a0fd99502
Lai, Jun S., Yuan, Wen Lun, Ong, Choon Nam, Tan, Kok Hian, Yap, Fabian, Chong, Yap-Seng, Gluckman, Peter D., Godfrey, Keith, Lee, Yung Seng, Chan, Jerry K.Y., Chan, Shiao-Yng and Chong, Mary F.F.
(2022)
Perinatal plasma carotenoid and vitamin E concentrations with maternal blood pressure during and after pregnancy.
Nutrition, Metabolism & Cardiovascular Diseases, 32 (12), .
(doi:10.1016/j.numecd.2022.07.019).
Abstract
Background and aims: Few studies examined the influence of carotenoids and vitamin E on blood pressure or hypertension during and after pregnancy. We related perinatal plasma concentrations of carotenoids and vitamin E (in individual forms and in combination) to blood pressure and hypertension at late pregnancy and 4 years post-pregnancy. Methods and results: In 684 women of the Growing Up in Singapore Towards Healthy Outcomes cohort, we quantified plasma carotenoids and vitamin E concentrations at delivery. Systolic blood pressure and diastolic blood pressure (SBP and DBP) around 37–39 weeks’ gestation were extracted from obstetric records and measured at 4 years post-pregnancy. Principal component analysis derived patterns of carotenoids (CP) and vitamin E. Associations were examined using linear or logistic regressions adjusting for confounders. Two carotenoids (CP1: α-carotene, β-carotene, and lutein; CP2: zeaxanthin, lycopene, and β-cryptoxanthin) and one vitamin E (γ-, δ-, and α-tocopherols) patterns were derived. CP1 (1SD score increment) was associated with lower SBP and DBP [β (95% CI): −2.36 (−3.47, −1.26) and −1.37 (−2.21, −0.53) mmHg] at late pregnancy> and 4 years post-pregnancy [-1.45 (−2.72, −0.18) and −0.99 (−1.98, −0.01) mmHg]. Higher β-cryptoxanthin concentrations were associated with lower SBP and DBP [-1.50 (−2.49, −0.51) and −1.20 (−1.95, −0.46) mmHg] at late pregnancy. Individual vitamin E and their pattern were not associated with blood pressure or hypertension. Conclusion: Higher perinatal α-carotene, β-carotene, and lutein concentrations are associated with lower blood pressure in women at late pregnancy and post-pregnancy. Foods rich in these carotenoids, such as red-, orange-, and dark-green-colored vegetables, might be beneficial for blood pressure during and after pregnancy.
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Accepted/In Press date: 22 July 2022
e-pub ahead of print date: 5 August 2022
Published date: December 2022
Additional Information:
Funding Information:
The GUSTO study is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health's National Medical Research Council ( NMRC ) – NMRC /TCR/004- NUS /2008; NMRC /TCR/012- NUHS /2014. Additional funding is provided by the Singapore Institute for Clinical Sciences , A∗STAR , Ministry of Education's Academic Research Fund Tier 1, and the 2018 BASF Nutrition Asia Research Grant. KMG is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research ( NIHR Senior Investigator (NF–SI-0515-10042), NIHR Southampton 1000DaysPlus Global Nutrition Research Group (17/63/154) and NIHR Southampton Biomedical Research Centre (IS-BRC-1215-20004)), the European Union ( Erasmus+ Programme ImpENSA 598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP) and the British Heart Foundation (RG/15/17/3174). The funding bodies had no influence on the study design, data collection, analysis, interpretation, and content of the manuscript.
Funding Information:
FY, KMG, and YSC have received reimbursement for speaking at conferences sponsored by companies selling nutritional products. KMG and YSC are part of an academic consortium that has received research funding from Abbott Nutrition, Nestlé, and Danone. All other authors declared no conflicts of interest.
Publisher Copyright:
© 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
Keywords:
Blood pressure, Carotenoids, Post-pregnancy, Pregnancy, Vitamin E
Identifiers
Local EPrints ID: 468944
URI: http://eprints.soton.ac.uk/id/eprint/468944
ISSN: 0939-4753
PURE UUID: 5fc7b80a-1f39-43a0-924b-e95181e99be4
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Date deposited: 01 Sep 2022 17:04
Last modified: 17 Mar 2024 07:26
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Contributors
Author:
Jun S. Lai
Author:
Wen Lun Yuan
Author:
Choon Nam Ong
Author:
Kok Hian Tan
Author:
Fabian Yap
Author:
Yap-Seng Chong
Author:
Peter D. Gluckman
Author:
Yung Seng Lee
Author:
Jerry K.Y. Chan
Author:
Shiao-Yng Chan
Author:
Mary F.F. Chong
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