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Endometrial gland specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss

Endometrial gland specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss
Endometrial gland specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss
Endometrial glands are essential for fertility, consisting of ciliated and secretory cells that facilitate a suitable uterine environment for embryo implantation. This study sought to determine whether an endometrial gland-specific transcriptome and splicing profile are altered in women with recurrent pregnancy loss. Our data provide a comprehensive catalogue of cilia and progestagen-associated endometrial protein (PAEP) gene isoforms and relative exon usage in endometrial glands. We report a previously unannotated endometrial gland cilia transcript GALNT11 and its susceptibility to exon skipping. Key endometrial receptivity gene transcripts are also reported to change in endometrial glands of women with recurrent pregnancy loss. The endometrial gland cilia and PAEP targets identified in this study could be used to identify a perturbed endometrium, isolate causes of recurrent pregnancy loss and develop targeted therapies in personalised medicine.
fertility, gland secretions, exon skipping, gene transcription, uterine environment
2633-8386
162-72
Pearson-Farr, Jennifer
6c1e2bb4-ea4f-4fbe-a3fa-36a47757dc21
Wheway, Gabrielle
2e547e5d-b921-4243-a071-2208fd4cc090
Jongen, Maaike SA
13f00bd0-5bf2-400f-a3ac-aa90d2180327
Goggin, Patricia
90c80d17-9f7a-4401-8e6f-919c63efe5e6
Lewis, Rohan
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Cheong, Ying
4efbba2a-3036-4dce-82f1-8b4017952c83
Cleal, Jane
18cfd2c1-bd86-4a13-b38f-c321af56da66
Pearson-Farr, Jennifer
6c1e2bb4-ea4f-4fbe-a3fa-36a47757dc21
Wheway, Gabrielle
2e547e5d-b921-4243-a071-2208fd4cc090
Jongen, Maaike SA
13f00bd0-5bf2-400f-a3ac-aa90d2180327
Goggin, Patricia
90c80d17-9f7a-4401-8e6f-919c63efe5e6
Lewis, Rohan
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Cheong, Ying
4efbba2a-3036-4dce-82f1-8b4017952c83
Cleal, Jane
18cfd2c1-bd86-4a13-b38f-c321af56da66

Pearson-Farr, Jennifer, Wheway, Gabrielle, Jongen, Maaike SA, Goggin, Patricia, Lewis, Rohan, Cheong, Ying and Cleal, Jane (2022) Endometrial gland specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss. Reproduction and Fertility, 3 (3), 162-72. (doi:10.1530/RAF-22-0002).

Record type: Article

Abstract

Endometrial glands are essential for fertility, consisting of ciliated and secretory cells that facilitate a suitable uterine environment for embryo implantation. This study sought to determine whether an endometrial gland-specific transcriptome and splicing profile are altered in women with recurrent pregnancy loss. Our data provide a comprehensive catalogue of cilia and progestagen-associated endometrial protein (PAEP) gene isoforms and relative exon usage in endometrial glands. We report a previously unannotated endometrial gland cilia transcript GALNT11 and its susceptibility to exon skipping. Key endometrial receptivity gene transcripts are also reported to change in endometrial glands of women with recurrent pregnancy loss. The endometrial gland cilia and PAEP targets identified in this study could be used to identify a perturbed endometrium, isolate causes of recurrent pregnancy loss and develop targeted therapies in personalised medicine.

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FINAL Resubmited manuscript J.Pearson-Farr reproduction and fertility - Accepted Manuscript
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[26338386 - Reproduction and Fertility] Endometrial gland-specific progestagen-associated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss - Version of Record
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Accepted/In Press date: 15 August 2022
e-pub ahead of print date: 2 September 2022
Published date: 2 September 2022
Additional Information: The acceptance email is dated 15/08/2022 but the hyperlink http://dx.doi.org/10.1530/RAF-22-0002 goes to an on-line version with the date of 01/08/2022. I've put the first date down and listed as accepted/in press. bioRxiv preprint DOI: 10.1101/2021.09.09.459643 I hope that is okay.
Keywords: fertility, gland secretions, exon skipping, gene transcription, uterine environment
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Identifiers

Local EPrints ID: 469737
URI: http://eprints.soton.ac.uk/id/eprint/469737
DOI: doi:10.1530/RAF-22-0002
ISSN: 2633-8386
PURE UUID: e6d01e77-57bb-4596-aa7c-c40d23a875cd
ORCID for Gabrielle Wheway: ORCID iD orcid.org/0000-0002-0494-0783
ORCID for Rohan Lewis: ORCID iD orcid.org/0000-0003-4044-9104
ORCID for Ying Cheong: ORCID iD orcid.org/0000-0001-7687-4597
ORCID for Jane Cleal: ORCID iD orcid.org/0000-0001-7978-4327

Catalogue record

Date deposited: 23 Sep 2022 16:34
Last modified: 17 Mar 2024 03:53

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Contributors

Author: Jennifer Pearson-Farr
Author: Gabrielle Wheway ORCID iD
Author: Maaike SA Jongen
Author: Patricia Goggin
Author: Rohan Lewis ORCID iD
Author: Ying Cheong ORCID iD
Author: Jane Cleal ORCID iD

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