Long‐term fatigue following aneurysmal subarachnoid haemorrhage and the impact on employment
Long‐term fatigue following aneurysmal subarachnoid haemorrhage and the impact on employment
Background and purpose
Fatigue is common following aneurysmal subarachnoid haemorrhage (aSAH) but little is known about its frequency, prognosis and impact on employment. The aim of this study was to assess the frequency of fatigue, whether it changes over time and the relationship to employment in the long term.
Methods
This was a retrospective observational study of aSAH cases and matched controls from the UK Biobank. The presence of fatigue was compared between cases and controls using the chi-squared test. The change in frequency over time was assessed using Spearman's rank correlation coefficient. The effect of fatigue on employment was assessed using mediation analysis.
Results
Fatigue is more common following aSAH compared to matched controls (aSAH 18.7%; controls 13.7%; χ2 = 13.0, p < 0.001) at a mean follow-up of 123 months. Fatigue gradually improves over time with significant fatigue decreasing by 50% from ~20% in the first year to ~10% after a decade (p = 0.04). Fatigue significantly mediated 24.0% of the effect of aSAH status on employment.
Conclusions
Fatigue is common following aSAH and persists in the long term. It gradually improves over time but has a major impact on aSAH survivors, significantly contributing to unemployment following haemorrhage. Further work is required to develop treatments and management strategies for fatigue with a view to improving this symptom and consequently employment following aSAH.
employment, fatigue, outcome, subarachnoid haemorrhage
3564-3570
Gaastra, Ben
c7b7f371-706b-4d59-9150-94e8f254e205
Carmichael, Harry
46780173-28a7-4490-8438-2d402f7d21f8
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Bulters, Diederik
d6f9644a-a32f-45d8-b5ed-be54486ec21d
December 2022
Gaastra, Ben
c7b7f371-706b-4d59-9150-94e8f254e205
Carmichael, Harry
46780173-28a7-4490-8438-2d402f7d21f8
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
Bulters, Diederik
d6f9644a-a32f-45d8-b5ed-be54486ec21d
Gaastra, Ben, Carmichael, Harry, Galea, Ian and Bulters, Diederik
(2022)
Long‐term fatigue following aneurysmal subarachnoid haemorrhage and the impact on employment.
European Journal of Neurology, 29 (12), .
(doi:10.1111/ene.15533).
Abstract
Background and purpose
Fatigue is common following aneurysmal subarachnoid haemorrhage (aSAH) but little is known about its frequency, prognosis and impact on employment. The aim of this study was to assess the frequency of fatigue, whether it changes over time and the relationship to employment in the long term.
Methods
This was a retrospective observational study of aSAH cases and matched controls from the UK Biobank. The presence of fatigue was compared between cases and controls using the chi-squared test. The change in frequency over time was assessed using Spearman's rank correlation coefficient. The effect of fatigue on employment was assessed using mediation analysis.
Results
Fatigue is more common following aSAH compared to matched controls (aSAH 18.7%; controls 13.7%; χ2 = 13.0, p < 0.001) at a mean follow-up of 123 months. Fatigue gradually improves over time with significant fatigue decreasing by 50% from ~20% in the first year to ~10% after a decade (p = 0.04). Fatigue significantly mediated 24.0% of the effect of aSAH status on employment.
Conclusions
Fatigue is common following aSAH and persists in the long term. It gradually improves over time but has a major impact on aSAH survivors, significantly contributing to unemployment following haemorrhage. Further work is required to develop treatments and management strategies for fatigue with a view to improving this symptom and consequently employment following aSAH.
Text
Gaastra et al 2022
- Accepted Manuscript
Text
Euro J of Neurology - 2022 - Gaastra - Long‐term fatigue following aneurysmal subarachnoid haemorrhage and the impact on
- Version of Record
More information
e-pub ahead of print date: 30 August 2022
Published date: December 2022
Additional Information:
Funding Information:
BG is funded by the Royal College of Surgeons of England, Society of British Neurological Surgeons, Barrow Foundation and Guarantors of Brain in addition to the Institute for Life Sciences, University of Southampton.
Funding Information:
The authors acknowledge the use of the IRIDIS High Performance Computing Facility and associated support services at the University of Southampton in the completion of this work. This research has been conducted using the UK Biobank Resource under application number 49305.
Publisher Copyright:
© 2022 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.
Keywords:
employment, fatigue, outcome, subarachnoid haemorrhage
Identifiers
Local EPrints ID: 470290
URI: http://eprints.soton.ac.uk/id/eprint/470290
ISSN: 1351-5101
PURE UUID: b80c6ea5-5e0b-4bd9-b547-372c6dc05692
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Date deposited: 05 Oct 2022 16:53
Last modified: 17 Mar 2024 04:07
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Contributors
Author:
Harry Carmichael
Author:
Diederik Bulters
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