Quality of life in older adults with chronic kidney disease and transient changes in renal function: findings from the Oxford Renal Cohort
Quality of life in older adults with chronic kidney disease and transient changes in renal function: findings from the Oxford Renal Cohort
Background: Quality of life (QoL) is an important measure of disease burden and general health perception. The relationship between early chronic kidney disease (CKD) and QoL remains poorly understood. The Oxford Renal Study (OxRen) cohort comprises 1063 adults aged ≥60 years from UK primary care practices screened for early CKD, grouped according to existing or screen-detected CKD diagnoses, or biochemistry results indicative of reduced renal function (referred to as transient estimated glomerular filtration rate (eGFR) reduction).
Objectives: This study aimed to compare QoL in participants known to have CKD at recruitment to those identified as having CKD through a screening programme.
Methods: Health profile data and multi-attribute utility scores were reported for two generic questionnaires: 5-level EuroQol-5 Dimension (EQ-5D-5L) and ICEpop CAPability measure for Adults (ICECAP-A). QoL was compared between patients with existing and screen-detected CKD; those with transient eGFR reduction served as the reference group in univariable and multivariable linear regression.
Results: Mean and standard deviation utility scores were not significantly different between the subgroups for EQ-5D-5L (screen-detected:0.785±0.156, n = 480, transient:0.779±0.157, n = 261, existing CKD:0.763±0.171, n = 322, p = 0.216) or ICECAP-A (screen-detected:0.909±0.094, transient:0.904±0.110, existing CKD:0.894±0.115, p = 0.200). Age, smoking status, and number of comorbidities were identified as independent predictors of QoL in this cohort.
Conclusion: QoL of participants with existing CKD diagnoses was not significantly different from those with screen-detected CKD or transient eGFR reduction and was similar to UK mean scores for the same age, suggesting that patient burden of early CKD is minor. Moreover, CKD-related comorbidities contribute more significantly to disease burden in earlier stages of CKD than renal function per se. Larger prospective studies are required to define the relationship between QoL and CKD progression more precisely. These data also confirm the essentially asymptomatic nature of CKD, implying that routine screening or case finding are required to diagnose it.
e0275572
Busa, Isabella
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Ordóñez-Mena, Jose
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Yang, Yaling
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Wolstenholme, Jane
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Petrou, Stavros
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Taylor, Clare J.
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O’Callaghan, Chris A.
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Fraser, Simon
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Taal, Maarten
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McManus, Richard J.
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Hirst, Jennifer A.
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Hobbs, F.D.Richard
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14 October 2022
Busa, Isabella
0e0f0b13-aa7c-4bed-9286-59fc432c5e62
Ordóñez-Mena, Jose
d00052a1-1298-4551-9c84-e7d17351c132
Yang, Yaling
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Wolstenholme, Jane
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Petrou, Stavros
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Taylor, Clare J.
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O’Callaghan, Chris A.
bc0cf39c-9d0f-4eb3-9b9b-3fc77a545fc0
Fraser, Simon
135884b6-8737-4e8a-a98c-5d803ac7a2dc
Taal, Maarten
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McManus, Richard J.
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Hirst, Jennifer A.
fec754b7-430a-49c7-afe5-2539ca5f72a1
Hobbs, F.D.Richard
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Busa, Isabella, Ordóñez-Mena, Jose, Yang, Yaling, Wolstenholme, Jane, Petrou, Stavros, Taylor, Clare J., O’Callaghan, Chris A., Fraser, Simon, Taal, Maarten, McManus, Richard J., Hirst, Jennifer A. and Hobbs, F.D.Richard
(2022)
Quality of life in older adults with chronic kidney disease and transient changes in renal function: findings from the Oxford Renal Cohort.
PLoS ONE, 17 (10), , [e0275572].
(doi:10.1371/journal.pone.0275572).
Abstract
Background: Quality of life (QoL) is an important measure of disease burden and general health perception. The relationship between early chronic kidney disease (CKD) and QoL remains poorly understood. The Oxford Renal Study (OxRen) cohort comprises 1063 adults aged ≥60 years from UK primary care practices screened for early CKD, grouped according to existing or screen-detected CKD diagnoses, or biochemistry results indicative of reduced renal function (referred to as transient estimated glomerular filtration rate (eGFR) reduction).
Objectives: This study aimed to compare QoL in participants known to have CKD at recruitment to those identified as having CKD through a screening programme.
Methods: Health profile data and multi-attribute utility scores were reported for two generic questionnaires: 5-level EuroQol-5 Dimension (EQ-5D-5L) and ICEpop CAPability measure for Adults (ICECAP-A). QoL was compared between patients with existing and screen-detected CKD; those with transient eGFR reduction served as the reference group in univariable and multivariable linear regression.
Results: Mean and standard deviation utility scores were not significantly different between the subgroups for EQ-5D-5L (screen-detected:0.785±0.156, n = 480, transient:0.779±0.157, n = 261, existing CKD:0.763±0.171, n = 322, p = 0.216) or ICECAP-A (screen-detected:0.909±0.094, transient:0.904±0.110, existing CKD:0.894±0.115, p = 0.200). Age, smoking status, and number of comorbidities were identified as independent predictors of QoL in this cohort.
Conclusion: QoL of participants with existing CKD diagnoses was not significantly different from those with screen-detected CKD or transient eGFR reduction and was similar to UK mean scores for the same age, suggesting that patient burden of early CKD is minor. Moreover, CKD-related comorbidities contribute more significantly to disease burden in earlier stages of CKD than renal function per se. Larger prospective studies are required to define the relationship between QoL and CKD progression more precisely. These data also confirm the essentially asymptomatic nature of CKD, implying that routine screening or case finding are required to diagnose it.
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OxRen manuscript final
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Accepted/In Press date: 19 September 2022
e-pub ahead of print date: 14 October 2022
Published date: 14 October 2022
Additional Information:
Funding Information:
This research was funded by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (OUHT BRC) (grant reference: BRC-1215-20008). JAH, JMOM and FDRH are partly supported by the NIHR Biomedical Research Centre, Oxford. JMOM and FDRH also receive support from the NIHR Applied Research Collaboration (ARC) Oxford Thames Valley. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2022 Busa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Local EPrints ID: 470752
URI: http://eprints.soton.ac.uk/id/eprint/470752
ISSN: 1932-6203
PURE UUID: e6681ebf-8e8d-4b19-bb34-5b5be0183407
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Date deposited: 19 Oct 2022 16:50
Last modified: 15 Oct 2024 01:41
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Contributors
Author:
Isabella Busa
Author:
Jose Ordóñez-Mena
Author:
Yaling Yang
Author:
Jane Wolstenholme
Author:
Stavros Petrou
Author:
Clare J. Taylor
Author:
Chris A. O’Callaghan
Author:
Maarten Taal
Author:
Richard J. McManus
Author:
Jennifer A. Hirst
Author:
F.D.Richard Hobbs
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