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Parallel randomized controlled feasibility trials of the "Active Brains" digital intervention to protect cognitive health in adults aged 60-85

Parallel randomized controlled feasibility trials of the "Active Brains" digital intervention to protect cognitive health in adults aged 60-85
Parallel randomized controlled feasibility trials of the "Active Brains" digital intervention to protect cognitive health in adults aged 60-85
Introduction: Multidomain interventions to address modifiable risk factors for dementia are promising, but require more cost-effective, scalable delivery. This study investigated the feasibility of the “Active Brains” digital behavior change intervention and its trial procedures.

Materials and methods: Active Brains aims to reduce cognitive decline by promoting physical activity, healthy eating, and online cognitive training. We conducted 12-month parallel-design randomized controlled feasibility trials of “Active Brains” amongst “lower cognitive scoring” (n = 180) and “higher cognitive scoring” (n = 180) adults aged 60–85.

Results: We collected 67.2 and 76.1% of our 12-month primary outcome (Baddeley verbal reasoning task) data for the “lower cognitive score” and “higher cognitive score” groups, respectively. Usage of “Active Brains” indicated overall feasibility and satisfactory engagement with the physical activity intervention content (which did not require sustained online engagement), but engagement with online cognitive training was limited. Uptake of the additional brief telephone support appeared to be higher in the “lower cognitive score” trial. Preliminary descriptive trends in the primary outcome data might indicate a protective effect of Active Brains against cognitive decline, but further investigation in fully-powered trials is required to answer this definitively.

Discussion: Whilst initial uptake and engagement with the online intervention was modest, it was in line with typical usage of other digital behavior change interventions, and early indications from the descriptive analysis of the primary outcome and behavioral data suggest that further exploration of the potential protective benefits of Active Brains are warranted. The study also identified minor modifications to procedures, particularly to improve online primary-outcome completion. Further investigation of Active Brains will now seek to determine its efficacy in protecting cognitive performance amongst adults aged 60–85 with varied levels of existing cognitive performance.
behavior change, cognitive training, dementia prevention, healthy eating, physical activity
2296-2565
Essery, Rosie
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Pollet, Sebastien
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Bradbury, Katherine
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Western, Max J. J.
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Grey, Elisabeth
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Denison-Day, James
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Smith, Kirsten A.
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Hayter, Victoria
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Kelly, Joanne
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Somerville, Jane
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Stuart, Beth
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Becque, Taeko
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Zhang, Jin
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Slodkowska-Barabasz, Joanna
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Mowbray, Fiona
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Ferrey, Anne
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Yao, Guiqing
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Zhu, Shihua
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Kendrick, Tony
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Griffin, Simon
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Mutrie, Nanette
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Robinson, Sian
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Brooker, Helen
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Griffiths, Gareth
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Robinson, Louise
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Rossor, Martin
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Ballard, Clive
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Gallacher, John
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Rathod, Shanaya
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Gudgin, Bernard
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Phillips, Rosemary
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Stokes, Tom
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Niven, John
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Little, Paul
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Yardley, Lucy
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Essery, Rosie
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Pollet, Sebastien
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Bradbury, Katherine
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Western, Max J. J.
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Grey, Elisabeth
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Denison-Day, James
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Smith, Kirsten A.
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Hayter, Victoria
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Kelly, Joanne
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Somerville, Jane
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Stuart, Beth
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Becque, Taeko
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Zhang, Jin
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Mowbray, Fiona
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Ferrey, Anne
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Yao, Guiqing
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Zhu, Shihua
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Kendrick, Tony
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Griffin, Simon
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Robinson, Sian
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Brooker, Helen
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Rossor, Martin
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Ballard, Clive
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Gallacher, John
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Rathod, Shanaya
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Gudgin, Bernard
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Phillips, Rosemary
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Stokes, Tom
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Niven, John
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Little, Paul
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Yardley, Lucy
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Essery, Rosie, Pollet, Sebastien, Bradbury, Katherine, Western, Max J. J., Grey, Elisabeth, Denison-Day, James, Smith, Kirsten A., Hayter, Victoria, Kelly, Joanne, Somerville, Jane, Stuart, Beth, Becque, Taeko, Zhang, Jin, Slodkowska-Barabasz, Joanna, Mowbray, Fiona, Ferrey, Anne, Yao, Guiqing, Zhu, Shihua, Kendrick, Tony, Griffin, Simon, Mutrie, Nanette, Robinson, Sian, Brooker, Helen, Griffiths, Gareth, Robinson, Louise, Rossor, Martin, Ballard, Clive, Gallacher, John, Rathod, Shanaya, Gudgin, Bernard, Phillips, Rosemary, Stokes, Tom, Niven, John, Little, Paul and Yardley, Lucy (2022) Parallel randomized controlled feasibility trials of the "Active Brains" digital intervention to protect cognitive health in adults aged 60-85. Frontiers in Public Health, 10, [962873]. (doi:10.3389/fpubh.2022.962873).

Record type: Article

Abstract

Introduction: Multidomain interventions to address modifiable risk factors for dementia are promising, but require more cost-effective, scalable delivery. This study investigated the feasibility of the “Active Brains” digital behavior change intervention and its trial procedures.

Materials and methods: Active Brains aims to reduce cognitive decline by promoting physical activity, healthy eating, and online cognitive training. We conducted 12-month parallel-design randomized controlled feasibility trials of “Active Brains” amongst “lower cognitive scoring” (n = 180) and “higher cognitive scoring” (n = 180) adults aged 60–85.

Results: We collected 67.2 and 76.1% of our 12-month primary outcome (Baddeley verbal reasoning task) data for the “lower cognitive score” and “higher cognitive score” groups, respectively. Usage of “Active Brains” indicated overall feasibility and satisfactory engagement with the physical activity intervention content (which did not require sustained online engagement), but engagement with online cognitive training was limited. Uptake of the additional brief telephone support appeared to be higher in the “lower cognitive score” trial. Preliminary descriptive trends in the primary outcome data might indicate a protective effect of Active Brains against cognitive decline, but further investigation in fully-powered trials is required to answer this definitively.

Discussion: Whilst initial uptake and engagement with the online intervention was modest, it was in line with typical usage of other digital behavior change interventions, and early indications from the descriptive analysis of the primary outcome and behavioral data suggest that further exploration of the potential protective benefits of Active Brains are warranted. The study also identified minor modifications to procedures, particularly to improve online primary-outcome completion. Further investigation of Active Brains will now seek to determine its efficacy in protecting cognitive performance amongst adults aged 60–85 with varied levels of existing cognitive performance.

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ESSERY - FRONTIERS _ RECON Feasibility Trial manuscript full draft FINAL - Accepted Manuscript
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More information

Accepted/In Press date: 30 August 2022
Published date: 20 September 2022
Additional Information: Copyright © 2022 Essery, Pollet, Bradbury, Western, Grey, Denison-Day, Smith, Hayter, Kelly, Somerville, Stuart, Becque, Zhang, Slodkowska-Barabasz, Mowbray, Ferrey, Yao, Zhu, Kendrick, Griffin, Mutrie, Robinson, Brooker, Griffiths, Robinson, Rossor, Ballard, Gallacher, Rathod, Gudgin, Phillips, Stokes, Niven, Little and Yardley.
Keywords: behavior change, cognitive training, dementia prevention, healthy eating, physical activity

Identifiers

Local EPrints ID: 471274
URI: http://eprints.soton.ac.uk/id/eprint/471274
ISSN: 2296-2565
PURE UUID: 76ae7234-6041-4ba6-94bd-1c0eaef99588
ORCID for Sebastien Pollet: ORCID iD orcid.org/0000-0001-9924-9225
ORCID for Katherine Bradbury: ORCID iD orcid.org/0000-0001-5513-7571
ORCID for Beth Stuart: ORCID iD orcid.org/0000-0001-5432-7437
ORCID for Taeko Becque: ORCID iD orcid.org/0000-0002-0362-3794
ORCID for Fiona Mowbray: ORCID iD orcid.org/0000-0002-3297-4163
ORCID for Tony Kendrick: ORCID iD orcid.org/0000-0003-1618-9381
ORCID for Sian Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for Gareth Griffiths: ORCID iD orcid.org/0000-0002-9579-8021
ORCID for Lucy Yardley: ORCID iD orcid.org/0000-0002-3853-883X

Catalogue record

Date deposited: 01 Nov 2022 17:52
Last modified: 02 Nov 2022 02:46

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Contributors

Author: Rosie Essery
Author: Max J. J. Western
Author: Elisabeth Grey
Author: Victoria Hayter
Author: Joanne Kelly
Author: Jane Somerville
Author: Beth Stuart ORCID iD
Author: Taeko Becque ORCID iD
Author: Jin Zhang
Author: Fiona Mowbray ORCID iD
Author: Anne Ferrey
Author: Guiqing Yao
Author: Shihua Zhu
Author: Tony Kendrick ORCID iD
Author: Simon Griffin
Author: Nanette Mutrie
Author: Sian Robinson ORCID iD
Author: Helen Brooker
Author: Louise Robinson
Author: Martin Rossor
Author: Clive Ballard
Author: John Gallacher
Author: Shanaya Rathod
Author: Bernard Gudgin
Author: Rosemary Phillips
Author: Tom Stokes
Author: John Niven
Author: Paul Little
Author: Lucy Yardley ORCID iD

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