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How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals

How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals
How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals

We undertook a survey of UK healthcare professionals through the UK Dermatology Clinical Trials Network and British Dermatological Nursing Group to understand clinicians' routine practice of prescribing oral isotretinoin for treatment of acne vulgaris. We also wanted to understand clinicians' experiences and views on prescribing low daily dose regimens. Overall, the survey showed that clinicians adopted a patient-centred approach when deciding isotretinoin dosing. The rationale for using a low-dose regimen varied, but was focused on patient wellbeing during treatment. Some clinicians were concerned that use of a low-dose regimen could be less effective and lead to longer treatment durations. The survey results will be useful to inform a clinical trial investigating the effectiveness and safety of low daily dose isotretinoin for the treatment of acne.

Acne Vulgaris/drug therapy, Administration, Oral, Dermatologic Agents/therapeutic use, Dermatology, Humans, Isotretinoin/therapeutic use, Treatment Outcome, United Kingdom
0307-6938
20-23
Moledina, Zahra
fde6d28d-5ed5-4351-a7a5-aa00b1470657
McPhee, Margaret
77faabbb-7dc6-4c5f-8bd6-26401eadb8f5
Ravenscroft, Jane C
3829aaf0-1391-48a8-945a-e05d278b35d6
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
Radley, Kathy
870ce00b-0f91-48cd-a787-22e6476ccdf5
Thomas, Kim S
75e143ff-868e-47dc-b892-c9745a7e496a
Burden-Teh, Esther
4b1ee272-e52e-40dc-b517-cdaa9dac233b
Sach, Tracey
5c09256f-ebed-4d14-853a-181f6c92d6f2
Acne-ID Trial Development Team
Moledina, Zahra
fde6d28d-5ed5-4351-a7a5-aa00b1470657
McPhee, Margaret
77faabbb-7dc6-4c5f-8bd6-26401eadb8f5
Ravenscroft, Jane C
3829aaf0-1391-48a8-945a-e05d278b35d6
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
Radley, Kathy
870ce00b-0f91-48cd-a787-22e6476ccdf5
Thomas, Kim S
75e143ff-868e-47dc-b892-c9745a7e496a
Burden-Teh, Esther
4b1ee272-e52e-40dc-b517-cdaa9dac233b
Sach, Tracey
5c09256f-ebed-4d14-853a-181f6c92d6f2

Sach, Tracey , Acne-ID Trial Development Team (2023) How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals. Clinical and Experimental Dermatology, 48 (1), 20-23. (doi:10.1093/ced/llac015).

Record type: Article

Abstract

We undertook a survey of UK healthcare professionals through the UK Dermatology Clinical Trials Network and British Dermatological Nursing Group to understand clinicians' routine practice of prescribing oral isotretinoin for treatment of acne vulgaris. We also wanted to understand clinicians' experiences and views on prescribing low daily dose regimens. Overall, the survey showed that clinicians adopted a patient-centred approach when deciding isotretinoin dosing. The rationale for using a low-dose regimen varied, but was focused on patient wellbeing during treatment. Some clinicians were concerned that use of a low-dose regimen could be less effective and lead to longer treatment durations. The survey results will be useful to inform a clinical trial investigating the effectiveness and safety of low daily dose isotretinoin for the treatment of acne.

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How is isotretinoin prescribed for the treatment of acne vulgaris - Revised MANUSCRIPT_clean copy - Accepted Manuscript
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Accepted/In Press date: 15 September 2022
Published date: 20 January 2023
Additional Information: © The Author(s) 2022. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Keywords: Acne Vulgaris/drug therapy, Administration, Oral, Dermatologic Agents/therapeutic use, Dermatology, Humans, Isotretinoin/therapeutic use, Treatment Outcome, United Kingdom

Identifiers

Local EPrints ID: 471567
URI: http://eprints.soton.ac.uk/id/eprint/471567
DOI: doi:10.1093/ced/llac015
ISSN: 0307-6938
PURE UUID: 0821da0e-d4f9-43f8-982c-4ab425c790a2
ORCID for Tracey Sach: ORCID iD orcid.org/0000-0002-8098-9220

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Date deposited: 11 Nov 2022 17:41
Last modified: 17 Mar 2024 07:33

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Contributors

Author: Zahra Moledina
Author: Margaret McPhee
Author: Jane C Ravenscroft
Author: Eugene Healy
Author: Kathy Radley
Author: Kim S Thomas
Author: Esther Burden-Teh
Author: Tracey Sach ORCID iD
Corporate Author: Acne-ID Trial Development Team

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