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Quality of Life of Long‐term childhood Acute Lymphoblastic Leukemia survivors: Comparison with healthy controls

Quality of Life of Long‐term childhood Acute Lymphoblastic Leukemia survivors: Comparison with healthy controls
Quality of Life of Long‐term childhood Acute Lymphoblastic Leukemia survivors: Comparison with healthy controls
Objective: Improved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need to elucidate the long-term quality of life (QoL) and domains of complaints in these patients. Furthermore, the main priorities of these patients need to be clarified. We assessed long-term QoL outcomes of survivors of childhood ALL compared to matched population controls.

Methods: QoL data were collected from survivors recruited in France and Belgium between 2012 and 2017, including the Short Form Health Survey (SF-12) and the Quality of Life Systemic Inventory (QLSI). The Wilcoxon test was used to compare SF-12 scale scores between survivors and matched population controls. For the QLSI, comparisons were mainly descriptive.

Results: one hundred and eighty-six survivors (mean age: 27.6 years; range: 18.1–52.8) at follow-up completed QoL measures, amongst whom 180 were matched to controls. Overall, survivors had higher QoL on all SF12 scale scores, indicating that they had better functioning compared to controls. Statistically significant differences on the SF12 were observed for Vitality, Social Functioning, Role Limitations due to Emotional Problems and Mental Health scales. QLSI outcomes suggested that survivors were happier than controls with Couple and Social Relations. Controls were unhappiest compared to survivors with Money, Love life, Self-esteem, Nutrition and Paid Work.

Conclusions: our findings suggest that survivors of childhood ALL have better QoL outcomes on some domains compared to the general population, specifically around social and emotional functioning, and that they tend to prioritize their relationships more. Interventions for improving QoL outcomes, might build on existing positive experiences with family, friends and partners.
1057-9249
Chantziara, Sofia
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Musoro, Jammbe
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Rowsell, Alison C.
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Sleurs, Charlotte
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Coens, Corneel
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Pe, Madeline
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Suciu, Stefan
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Kicinski, Michal
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Missotten, Pierre
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Vandecruys, Els
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Uyttebroeck, Anne
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Dresse, Marie‐françoise
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Pluchart, Claire
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Ferster, Alina
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Freycon, Claire
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Van Der Werff Ten Bosch, Jutte
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Rohrlich, Pierre
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Benoit, Yves
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Darlington, Anne‐sophie
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Piette, Caroline
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And On Behalf Of The European Organisation For Research,
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Group (clg, Treatment Of Cancer (eortc) Quality Of Life (qlg) And Childr
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Chantziara, Sofia
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Musoro, Jammbe
da52f8ef-ac98-4f1e-8443-fdcdcb4d91b3
Rowsell, Alison C.
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Sleurs, Charlotte
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Coens, Corneel
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Pe, Madeline
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Suciu, Stefan
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Kicinski, Michal
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Missotten, Pierre
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Vandecruys, Els
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Uyttebroeck, Anne
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Dresse, Marie‐françoise
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Pluchart, Claire
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Ferster, Alina
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Freycon, Claire
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Van Der Werff Ten Bosch, Jutte
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Rohrlich, Pierre
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Benoit, Yves
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Darlington, Anne‐sophie
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Piette, Caroline
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And On Behalf Of The European Organisation For Research,
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Group (clg, Treatment Of Cancer (eortc) Quality Of Life (qlg) And Childr
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Chantziara, Sofia, Musoro, Jammbe, Rowsell, Alison C., Sleurs, Charlotte, Coens, Corneel, Pe, Madeline, Suciu, Stefan, Kicinski, Michal, Missotten, Pierre, Vandecruys, Els, Uyttebroeck, Anne, Dresse, Marie‐françoise, Pluchart, Claire, Ferster, Alina, Freycon, Claire, Van Der Werff Ten Bosch, Jutte, Rohrlich, Pierre, Benoit, Yves, Darlington, Anne‐sophie, Piette, Caroline, And On Behalf Of The European Organisation For Research, and Group (clg, Treatment Of Cancer (eortc) Quality Of Life (qlg) And Childr (2022) Quality of Life of Long‐term childhood Acute Lymphoblastic Leukemia survivors: Comparison with healthy controls. Psycho-Oncology. (doi:10.1002/pon.6060).

Record type: Article

Abstract

Objective: Improved treatment landscape has led to better outcomes for paediatric acute lymphoblastic leukemia (ALL) survivors. As the number of survivors increase, we need to elucidate the long-term quality of life (QoL) and domains of complaints in these patients. Furthermore, the main priorities of these patients need to be clarified. We assessed long-term QoL outcomes of survivors of childhood ALL compared to matched population controls.

Methods: QoL data were collected from survivors recruited in France and Belgium between 2012 and 2017, including the Short Form Health Survey (SF-12) and the Quality of Life Systemic Inventory (QLSI). The Wilcoxon test was used to compare SF-12 scale scores between survivors and matched population controls. For the QLSI, comparisons were mainly descriptive.

Results: one hundred and eighty-six survivors (mean age: 27.6 years; range: 18.1–52.8) at follow-up completed QoL measures, amongst whom 180 were matched to controls. Overall, survivors had higher QoL on all SF12 scale scores, indicating that they had better functioning compared to controls. Statistically significant differences on the SF12 were observed for Vitality, Social Functioning, Role Limitations due to Emotional Problems and Mental Health scales. QLSI outcomes suggested that survivors were happier than controls with Couple and Social Relations. Controls were unhappiest compared to survivors with Money, Love life, Self-esteem, Nutrition and Paid Work.

Conclusions: our findings suggest that survivors of childhood ALL have better QoL outcomes on some domains compared to the general population, specifically around social and emotional functioning, and that they tend to prioritize their relationships more. Interventions for improving QoL outcomes, might build on existing positive experiences with family, friends and partners.

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e-pub ahead of print date: 28 October 2022

Identifiers

Local EPrints ID: 472267
URI: http://eprints.soton.ac.uk/id/eprint/472267
ISSN: 1057-9249
PURE UUID: bbc209fc-d69b-4efd-b404-b9c414f89659

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Date deposited: 30 Nov 2022 17:42
Last modified: 02 Dec 2022 17:52

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Contributors

Author: Sofia Chantziara
Author: Jammbe Musoro
Author: Alison C. Rowsell
Author: Charlotte Sleurs
Author: Corneel Coens
Author: Madeline Pe
Author: Stefan Suciu
Author: Michal Kicinski
Author: Pierre Missotten
Author: Els Vandecruys
Author: Anne Uyttebroeck
Author: Marie‐françoise Dresse
Author: Claire Pluchart
Author: Alina Ferster
Author: Claire Freycon
Author: Jutte Van Der Werff Ten Bosch
Author: Pierre Rohrlich
Author: Yves Benoit
Author: Caroline Piette
Author: And On Behalf Of The European Organisation For Research
Author: Treatment Of Cancer (eortc) Quality Of Life (qlg) And Childr Group (clg

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