International validation of the EORTC QLQ-ANL27, a field study to test the anal cancer-specific health-related quality of life questionnaire
International validation of the EORTC QLQ-ANL27, a field study to test the anal cancer-specific health-related quality of life questionnaire
Purpose: The European Organisation for Research and Treatment of Cancer (EORTC) health-related quality of life questionnaire for anal cancer (QLQ-ANL27) supplements the EORTC cancer generic measure (QLQ-C30) to measure concerns specific to people with anal cancer treated with chemoradiotherapy. This study tested the psychometric properties and acceptability of the QLQ-ANL27. Methods and Materials: People with anal cancer were recruited from 15 countries to complete the QLQ-C30 and QLQ-ANL27 and provide feedback on the QLQ-ANL27. Item responses, scale structure (multitrait scaling, factor analysis), reliability (internal consistency and reproducibility) and sensitivity (known group comparisons and responsiveness to change) of the QLQ-ANL27 were evaluated. Results: Data from 382 people were included in the analyses. The EORTC QLQ-ANL27 was acceptable, comprehensive, and easy to complete, taking an average 8 minutes to complete. Psychometric analyses supported the EORTC QLQ-ANL27 items and reliability (Cronbach's α ranging from 0.71-0.93 and test-retest coefficients above 0.7) and validity of the scales (particularly nonstoma bowel symptoms and pain/discomfort). Most scales distinguished people according to treatment phase and performance status. Bowel (nonstoma), pain/discomfort, and vaginal symptoms were sensitive to deteriorations over time. The stoma-related scales remained untested because of low numbers of people with a stoma. Revisions to the scoring and question ordering of the sexual items were proposed. Conclusions: The QLQ-ANL27 has good psychometric properties and is available in 16 languages for people treated with chemoradiotherapy for anal cancer. It is used in clinical trials and has a potential role in clinical practice.
Sodergren, Samantha
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Johnson, Colin
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Darlington, Anne-Sophie
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Nugent, Karen
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Gilbert, Alexandra
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Cocks, Kim
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Guren, Marianne Grønlie
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Rivin del Campo, Eleonor
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Brennan, Christine
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Christensen, Peter
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Chu, William
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Chung, Hans
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Dennis, Kristopher
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Gilbert, Duncan C.
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Glynne-Jones, Rob
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Jefford, Michaeel
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Johansson, Mia
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Johnsson, Anders
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Juul, Therese
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Kardamakis, Dimitrios
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Lai-Kwon, Julia
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McFarlane, Vicky
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Miguel, Isalia M.C.
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Nugent, Karen
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Peters, Femke
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Riechelmann, Rachel P.
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Turhal, Nazim S.
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Wong, Shun
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Vassiliou, Vassilios
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Sodergren, Samantha
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Johnson, Colin
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Darlington, Anne-Sophie
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Nugent, Karen
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Gilbert, Alexandra
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Cocks, Kim
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Guren, Marianne Grønlie
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Rivin del Campo, Eleonor
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Brennan, Christine
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Christensen, Peter
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Chu, William
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Chung, Hans
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Dennis, Kristopher
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Gilbert, Duncan C.
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Glynne-Jones, Rob
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Jefford, Michaeel
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Johansson, Mia
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Johnsson, Anders
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Juul, Therese
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Kardamakis, Dimitrios
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Lai-Kwon, Julia
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McFarlane, Vicky
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Miguel, Isalia M.C.
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Nugent, Karen
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Peters, Femke
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Riechelmann, Rachel P.
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Turhal, Nazim S.
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Wong, Shun
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Vassiliou, Vassilios
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Sodergren, Samantha, Johnson, Colin, Darlington, Anne-Sophie, Nugent, Karen, Gilbert, Alexandra, Cocks, Kim, Guren, Marianne Grønlie, Rivin del Campo, Eleonor, Brennan, Christine, Christensen, Peter, Chu, William, Chung, Hans, Dennis, Kristopher, Gilbert, Duncan C., Glynne-Jones, Rob, Jefford, Michaeel, Johansson, Mia, Johnsson, Anders, Juul, Therese, Kardamakis, Dimitrios, Lai-Kwon, Julia, McFarlane, Vicky, Miguel, Isalia M.C., Nugent, Karen, Peters, Femke, Riechelmann, Rachel P., Turhal, Nazim S., Wong, Shun and Vassiliou, Vassilios
(2022)
International validation of the EORTC QLQ-ANL27, a field study to test the anal cancer-specific health-related quality of life questionnaire.
International Journal of Radiation Oncology*Biology*Physics.
(doi:10.1016/j.ijrobp.2022.11.002).
Abstract
Purpose: The European Organisation for Research and Treatment of Cancer (EORTC) health-related quality of life questionnaire for anal cancer (QLQ-ANL27) supplements the EORTC cancer generic measure (QLQ-C30) to measure concerns specific to people with anal cancer treated with chemoradiotherapy. This study tested the psychometric properties and acceptability of the QLQ-ANL27. Methods and Materials: People with anal cancer were recruited from 15 countries to complete the QLQ-C30 and QLQ-ANL27 and provide feedback on the QLQ-ANL27. Item responses, scale structure (multitrait scaling, factor analysis), reliability (internal consistency and reproducibility) and sensitivity (known group comparisons and responsiveness to change) of the QLQ-ANL27 were evaluated. Results: Data from 382 people were included in the analyses. The EORTC QLQ-ANL27 was acceptable, comprehensive, and easy to complete, taking an average 8 minutes to complete. Psychometric analyses supported the EORTC QLQ-ANL27 items and reliability (Cronbach's α ranging from 0.71-0.93 and test-retest coefficients above 0.7) and validity of the scales (particularly nonstoma bowel symptoms and pain/discomfort). Most scales distinguished people according to treatment phase and performance status. Bowel (nonstoma), pain/discomfort, and vaginal symptoms were sensitive to deteriorations over time. The stoma-related scales remained untested because of low numbers of people with a stoma. Revisions to the scoring and question ordering of the sexual items were proposed. Conclusions: The QLQ-ANL27 has good psychometric properties and is available in 16 languages for people treated with chemoradiotherapy for anal cancer. It is used in clinical trials and has a potential role in clinical practice.
Text
International validation of the EORTC QLQ_ANL27
- Accepted Manuscript
More information
Accepted/In Press date: 1 November 2022
e-pub ahead of print date: 17 November 2022
Additional Information:
Funding Information:
This work was supported by funding from the European Organisation for Research and Treatment of Cancer Quality of Life Group (grant reference 014-2016).
Funding Information:
We thank Kirsty Bracewell, Alison Porges (Brighton and Sussex Hospital, UK), Ashkan Mehrnejad (Peter MacCallum Cancer Center, Victoria, Australia), Maurodsd Dsd (A.C. Camargo Cancer Center, Sao Paulo, Brazil), Edward Chow, Yasmeen M. Razvi (Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto), Saara Ali, Kaitlyn Chambers (Ottawa, Canada), Loukia Georgiou, Elisavet Papagergiou, Ioannis Stylianou, (Bank of Cyprus Oncology Centre, Nicosia, Cyprus), Manon Le Normand, Elisa Bertin (Cancerest, Paris, France), Nicola Flego (University of Florence, Florence, Italy), Tara Chalk (Mount Vernon Cancer Centre, Northwood, UK), Ragnhild Tvedt (Oslo University Hospital, Oslo, Norway), João Geraldes Freire, Mariana Laranjeiro Gouveia Santos (Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon, Portugal), Anna Hultqvist (Skåne University Hospital, Lund, Sweden), Karen-Lise Garm Spindler (Aarhus University Hospital, Denmark), Richard Cole, Catherine Coltart, Andrew Jackson, Emma Jarvis (University Hospital Southampton, UK), and Amy Din (University of Southampton). We also acknowledge the help and support provided by the CHES team. This work was supported by funding from the European Organisation for Research and Treatment of Cancer Quality of Life Group (grant reference 014-2016).
Publisher Copyright:
© 2022 Elsevier Inc.
Identifiers
Local EPrints ID: 472918
URI: http://eprints.soton.ac.uk/id/eprint/472918
ISSN: 0360-3016
PURE UUID: 29723486-4869-4451-95bb-6079ed4cdacd
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Date deposited: 06 Jan 2023 11:31
Last modified: 17 Mar 2024 07:36
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Contributors
Author:
Alexandra Gilbert
Author:
Kim Cocks
Author:
Marianne Grønlie Guren
Author:
Eleonor Rivin del Campo
Author:
Christine Brennan
Author:
Peter Christensen
Author:
William Chu
Author:
Hans Chung
Author:
Kristopher Dennis
Author:
Duncan C. Gilbert
Author:
Rob Glynne-Jones
Author:
Michaeel Jefford
Author:
Mia Johansson
Author:
Anders Johnsson
Author:
Therese Juul
Author:
Dimitrios Kardamakis
Author:
Julia Lai-Kwon
Author:
Vicky McFarlane
Author:
Isalia M.C. Miguel
Author:
Karen Nugent
Author:
Femke Peters
Author:
Rachel P. Riechelmann
Author:
Nazim S. Turhal
Author:
Shun Wong
Author:
Vassilios Vassiliou
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