The University of Southampton
University of Southampton Institutional Repository

Effect of maternal immunisation with multivalent vaccines containing inactivated poliovirus vaccine (IPV) on infant IPV immune response: a phase 4, multi-centre randomised trial

Effect of maternal immunisation with multivalent vaccines containing inactivated poliovirus vaccine (IPV) on infant IPV immune response: a phase 4, multi-centre randomised trial
Effect of maternal immunisation with multivalent vaccines containing inactivated poliovirus vaccine (IPV) on infant IPV immune response: a phase 4, multi-centre randomised trial
Multivalent diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine (DTaP/IPV) has been offered to pregnant women in the United Kingdom since 2012. To assess the impact of maternal DTaP/IPV immunisation on the infant immune response to IPV, we measured poliovirus-specific neutralising antibodies at 2, 5 and 13 months of age in a randomised, phase 4 study of Repevax or Boostrix/IPV in pregnancy and in a non-randomised group born to women not given DTaP/IPV in pregnancy. Infants whose mothers received DTaP/IPV were less likely to seroconvert after three IPV doses than those whose mothers did not receive DTaP/IPV. At 13 months of age, 63/110 (57.2 %), 46/108 (42.6 %) and 40/108 (37.0 %) were seropositive to types 1 to 3, compared with 20/22 (90.9 %), 20/22 (90.9 %) and 14/20 (70.0 %) (p-values 0.003, <0.001 and 0.012). UK infants whose mothers are given DTaP/IPV in pregnancy may be insufficiently protected against poliomyelitis until their pre-school booster.
0264-410X
1299 - 1302
Grassly, Nicholas C.
617151d3-82bb-42d5-a885-f4750244b485
Andrews, Nick
ea7589a4-0be1-492e-983c-42b82ad39004
Cooper, Gillian
0f2d78ff-5da1-4b88-8bd8-913ba6e5d24c
Stephens, Laura
592404f6-4e45-4aa9-80db-c27a5d969657
Waight, Pauline
f52160c5-5d48-4b0b-9e3f-50c26dd33c23
Jones, Christine E
48229079-8b58-4dcb-8374-d9481fe7b426
Heath, Paul T.
63cb2105-87d1-4f26-802a-c6b12fd3a493
Calvert, Anna
81e418f7-2180-46d4-af9e-61e79e703d65
Southern, Jo
b4536d6a-8449-48c5-bc05-d240f41e74a3
Martin, Javier
2bdde26e-9aa9-4079-95cd-018fc9ac4ad3
Miller, Elizabeth
0c76582b-6457-4215-98a8-bb869b8b1eb6
Grassly, Nicholas C.
617151d3-82bb-42d5-a885-f4750244b485
Andrews, Nick
ea7589a4-0be1-492e-983c-42b82ad39004
Cooper, Gillian
0f2d78ff-5da1-4b88-8bd8-913ba6e5d24c
Stephens, Laura
592404f6-4e45-4aa9-80db-c27a5d969657
Waight, Pauline
f52160c5-5d48-4b0b-9e3f-50c26dd33c23
Jones, Christine E
48229079-8b58-4dcb-8374-d9481fe7b426
Heath, Paul T.
63cb2105-87d1-4f26-802a-c6b12fd3a493
Calvert, Anna
81e418f7-2180-46d4-af9e-61e79e703d65
Southern, Jo
b4536d6a-8449-48c5-bc05-d240f41e74a3
Martin, Javier
2bdde26e-9aa9-4079-95cd-018fc9ac4ad3
Miller, Elizabeth
0c76582b-6457-4215-98a8-bb869b8b1eb6

Grassly, Nicholas C., Andrews, Nick, Cooper, Gillian, Stephens, Laura, Waight, Pauline, Jones, Christine E, Heath, Paul T., Calvert, Anna, Southern, Jo, Martin, Javier and Miller, Elizabeth (2023) Effect of maternal immunisation with multivalent vaccines containing inactivated poliovirus vaccine (IPV) on infant IPV immune response: a phase 4, multi-centre randomised trial. Vaccine, 41 (7), 1299 - 1302.

Record type: Article

Abstract

Multivalent diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine (DTaP/IPV) has been offered to pregnant women in the United Kingdom since 2012. To assess the impact of maternal DTaP/IPV immunisation on the infant immune response to IPV, we measured poliovirus-specific neutralising antibodies at 2, 5 and 13 months of age in a randomised, phase 4 study of Repevax or Boostrix/IPV in pregnancy and in a non-randomised group born to women not given DTaP/IPV in pregnancy. Infants whose mothers received DTaP/IPV were less likely to seroconvert after three IPV doses than those whose mothers did not receive DTaP/IPV. At 13 months of age, 63/110 (57.2 %), 46/108 (42.6 %) and 40/108 (37.0 %) were seropositive to types 1 to 3, compared with 20/22 (90.9 %), 20/22 (90.9 %) and 14/20 (70.0 %) (p-values 0.003, <0.001 and 0.012). UK infants whose mothers are given DTaP/IPV in pregnancy may be insufficiently protected against poliomyelitis until their pre-school booster.

Text
iMAP2 polio revisedliz clean - Accepted Manuscript
Available under License Creative Commons Attribution.
Download (66kB)
Text
1-s2.0-S0264410X23000579-main - Version of Record
Available under License Creative Commons Attribution.
Download (268kB)

More information

Accepted/In Press date: 15 January 2023
e-pub ahead of print date: 15 January 2023
Published date: 15 January 2023

Identifiers

Local EPrints ID: 474728
URI: http://eprints.soton.ac.uk/id/eprint/474728
ISSN: 0264-410X
PURE UUID: 6d60e69a-4116-4d96-861c-4aa7a8ea65f7
ORCID for Christine E Jones: ORCID iD orcid.org/0000-0003-1523-2368

Catalogue record

Date deposited: 02 Mar 2023 17:35
Last modified: 17 Mar 2024 03:45

Export record

Contributors

Author: Nicholas C. Grassly
Author: Nick Andrews
Author: Gillian Cooper
Author: Laura Stephens
Author: Pauline Waight
Author: Paul T. Heath
Author: Anna Calvert
Author: Jo Southern
Author: Javier Martin
Author: Elizabeth Miller

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×