Parent-offspring associations in body composition: findings from the Southampton women's survey prospective cohort study
Parent-offspring associations in body composition: findings from the Southampton women's survey prospective cohort study
Context: children born to parents who are overweight or obese have a high risk of adult obesity, but it is unclear if transgenerational associations relating to unfavorable body composition differ by parent.
Objective: to examine differential mother-offspring and father-offspring associations in body composition in early childhood.
Methods: a total of 240 mother-father-offspring trios from a prospective UK population-based pre-birth cohort (Southampton Women's Survey) were included for anthropometry and dual-energy x-ray absorptiometry assessment of whole-body-less-head body composition in the offspring at 3 different ages (4, 6-7, and 8-9 years) and in the mother and father at the 8- to 9-year offspring visit. Associations were assessed using linear regression adjusting for the other parent.
Results: positive associations between mother-daughter body mass index (BMI) and fat mass were observed at ages 6 to 7 (BMI: β = .29 SD/SD, 95% CI = .10, .48; fat mass β = .27 SD/SD, 95% CI = .05, .48) and 8 to 9 years (BMI: β = .33 SD/SD, 95% CI = .13, .54; fat mass β = .31 SD/SD, 95% CI = .12, .49), with similar associations at age 4 years but bounding the 95% CI. The mother-son, father-son, and father-daughter associations for BMI and fat mass were weaker at each of the ages studied.
Conclusion: 8A strong association between the fat mass of mothers and their daughters but not their sons was observed. In contrast, father-offspring body composition associations were not evident. The dimorphic parent-offspring effects suggest particular attention should be given to early prevention of unfavorable body composition in girls born to mothers with excess adiposity.
adiposity, developmental programming, obesity
e726-e733
Moon, Rebecca J.
954fb3ed-9934-4649-886d-f65944985a6b
D'Angelo, Stefania
13375ecd-1117-4b6e-99c0-32239f52eed6
Holroyd, Christopher R.
5283dd8d-2025-412f-b604-350a11fa0243
Crozier, Sarah R.
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Davies, Justin H.
9f18fcad-f488-4c72-ac23-c154995443a9
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
1 September 2023
Moon, Rebecca J.
954fb3ed-9934-4649-886d-f65944985a6b
D'Angelo, Stefania
13375ecd-1117-4b6e-99c0-32239f52eed6
Holroyd, Christopher R.
5283dd8d-2025-412f-b604-350a11fa0243
Crozier, Sarah R.
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Davies, Justin H.
9f18fcad-f488-4c72-ac23-c154995443a9
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Moon, Rebecca J., D'Angelo, Stefania, Holroyd, Christopher R., Crozier, Sarah R., Godfrey, Keith M., Davies, Justin H., Cooper, Cyrus and Harvey, Nicholas C.
(2023)
Parent-offspring associations in body composition: findings from the Southampton women's survey prospective cohort study.
Journal of Clinical Endocrinology & Metabolism, 108 (9), .
(doi:10.1210/clinem/dgad128).
Abstract
Context: children born to parents who are overweight or obese have a high risk of adult obesity, but it is unclear if transgenerational associations relating to unfavorable body composition differ by parent.
Objective: to examine differential mother-offspring and father-offspring associations in body composition in early childhood.
Methods: a total of 240 mother-father-offspring trios from a prospective UK population-based pre-birth cohort (Southampton Women's Survey) were included for anthropometry and dual-energy x-ray absorptiometry assessment of whole-body-less-head body composition in the offspring at 3 different ages (4, 6-7, and 8-9 years) and in the mother and father at the 8- to 9-year offspring visit. Associations were assessed using linear regression adjusting for the other parent.
Results: positive associations between mother-daughter body mass index (BMI) and fat mass were observed at ages 6 to 7 (BMI: β = .29 SD/SD, 95% CI = .10, .48; fat mass β = .27 SD/SD, 95% CI = .05, .48) and 8 to 9 years (BMI: β = .33 SD/SD, 95% CI = .13, .54; fat mass β = .31 SD/SD, 95% CI = .12, .49), with similar associations at age 4 years but bounding the 95% CI. The mother-son, father-son, and father-daughter associations for BMI and fat mass were weaker at each of the ages studied.
Conclusion: 8A strong association between the fat mass of mothers and their daughters but not their sons was observed. In contrast, father-offspring body composition associations were not evident. The dimorphic parent-offspring effects suggest particular attention should be given to early prevention of unfavorable body composition in girls born to mothers with excess adiposity.
Text
SWS triads body comp revision final 17012023 CLEAN
- Accepted Manuscript
More information
Accepted/In Press date: 28 February 2023
e-pub ahead of print date: 21 March 2023
Published date: 1 September 2023
Additional Information:
Funding Information:
This work was supported by grants from Medical Research Council (MRC) [MC_PC_21003; MC_PC_21001], British Heart Foundation, National Institute for Health and Care Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, NIHR Oxford Biomedical Research Centre, University of Oxford. The work leading to these results was supported by the European Union’s Seventh Framework Programme (FP7/ 2007–2013), projects EarlyNutrition, ODIN and LifeCycle under grant agreements numbers 289346, 613977 and 733206, and by the BBSRC (HDHL-Biomarkers, BB/ P028179/1), as part of the ALPHABET project, supported by an award made through the ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL), Horizon 2020 grant agreement number 696295. K.M.G. is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research (NIHR Senior Investigator (NF-SI-0515-10042) and NIHR Southampton Biomedical Research Centre (IS-BRC-1215-20004)), the European Union (Erasmus + Programme ImpENSA 598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP), British Heart Foundation (RG/15/17/ 3174, SP/F/21/150013) and the US National Institute On Aging of the National Institutes of Health (Award No. U24AG047867). R.J.M. is funded by Health Education England (HEE)/NIHR for this research project. For the purpose of Open Access, the author has applied a Creative Commons Attribution (CC BY) license to any Author Accepted Manuscript version arising from this submission.
Publisher Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.
Keywords:
adiposity, developmental programming, obesity
Identifiers
Local EPrints ID: 475715
URI: http://eprints.soton.ac.uk/id/eprint/475715
ISSN: 0021-972X
PURE UUID: a8d91ef2-9172-4c0d-88c4-9054c478c7ad
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Date deposited: 27 Mar 2023 16:30
Last modified: 21 Mar 2024 05:01
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Author:
Rebecca J. Moon
Author:
Stefania D'Angelo
Author:
Christopher R. Holroyd
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