Parent-offspring associations in body composition: findings from the Southampton women's survey prospective cohort study
Parent-offspring associations in body composition: findings from the Southampton women's survey prospective cohort study
Context: children born to parents who are overweight or obese have a high risk of adult obesity, but it is unclear if transgenerational associations relating to unfavorable body composition differ by parent.
Objective: to examine differential mother-offspring and father-offspring associations in body composition in early childhood.
Methods: a total of 240 mother-father-offspring trios from a prospective UK population-based pre-birth cohort (Southampton Women's Survey) were included for anthropometry and dual-energy x-ray absorptiometry assessment of whole-body-less-head body composition in the offspring at 3 different ages (4, 6-7, and 8-9 years) and in the mother and father at the 8- to 9-year offspring visit. Associations were assessed using linear regression adjusting for the other parent.
Results: positive associations between mother-daughter body mass index (BMI) and fat mass were observed at ages 6 to 7 (BMI: β = .29 SD/SD, 95% CI = .10, .48; fat mass β = .27 SD/SD, 95% CI = .05, .48) and 8 to 9 years (BMI: β = .33 SD/SD, 95% CI = .13, .54; fat mass β = .31 SD/SD, 95% CI = .12, .49), with similar associations at age 4 years but bounding the 95% CI. The mother-son, father-son, and father-daughter associations for BMI and fat mass were weaker at each of the ages studied.
Conclusion: 8A strong association between the fat mass of mothers and their daughters but not their sons was observed. In contrast, father-offspring body composition associations were not evident. The dimorphic parent-offspring effects suggest particular attention should be given to early prevention of unfavorable body composition in girls born to mothers with excess adiposity.
Moon, Rebecca J.
954fb3ed-9934-4649-886d-f65944985a6b
D'Angelo, Stefania
13375ecd-1117-4b6e-99c0-32239f52eed6
Holroyd, Christopher R.
5283dd8d-2025-412f-b604-350a11fa0243
Crozier, Sarah R.
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Davies, Justin H.
9f18fcad-f488-4c72-ac23-c154995443a9
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Moon, Rebecca J.
954fb3ed-9934-4649-886d-f65944985a6b
D'Angelo, Stefania
13375ecd-1117-4b6e-99c0-32239f52eed6
Holroyd, Christopher R.
5283dd8d-2025-412f-b604-350a11fa0243
Crozier, Sarah R.
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Davies, Justin H.
9f18fcad-f488-4c72-ac23-c154995443a9
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Moon, Rebecca J., D'Angelo, Stefania, Holroyd, Christopher R., Crozier, Sarah R., Godfrey, Keith M., Davies, Justin H., Cooper, Cyrus and Harvey, Nicholas C.
(2023)
Parent-offspring associations in body composition: findings from the Southampton women's survey prospective cohort study.
Journal of Clinical Endocrinology & Metabolism.
(doi:10.1210/clinem/dgad128).
Abstract
Context: children born to parents who are overweight or obese have a high risk of adult obesity, but it is unclear if transgenerational associations relating to unfavorable body composition differ by parent.
Objective: to examine differential mother-offspring and father-offspring associations in body composition in early childhood.
Methods: a total of 240 mother-father-offspring trios from a prospective UK population-based pre-birth cohort (Southampton Women's Survey) were included for anthropometry and dual-energy x-ray absorptiometry assessment of whole-body-less-head body composition in the offspring at 3 different ages (4, 6-7, and 8-9 years) and in the mother and father at the 8- to 9-year offspring visit. Associations were assessed using linear regression adjusting for the other parent.
Results: positive associations between mother-daughter body mass index (BMI) and fat mass were observed at ages 6 to 7 (BMI: β = .29 SD/SD, 95% CI = .10, .48; fat mass β = .27 SD/SD, 95% CI = .05, .48) and 8 to 9 years (BMI: β = .33 SD/SD, 95% CI = .13, .54; fat mass β = .31 SD/SD, 95% CI = .12, .49), with similar associations at age 4 years but bounding the 95% CI. The mother-son, father-son, and father-daughter associations for BMI and fat mass were weaker at each of the ages studied.
Conclusion: 8A strong association between the fat mass of mothers and their daughters but not their sons was observed. In contrast, father-offspring body composition associations were not evident. The dimorphic parent-offspring effects suggest particular attention should be given to early prevention of unfavorable body composition in girls born to mothers with excess adiposity.
Text
SWS triads body comp revision final 17012023 CLEAN
- Accepted Manuscript
Restricted to Repository staff only until 21 March 2024.
Request a copy
More information
Accepted/In Press date: 28 February 2023
e-pub ahead of print date: 21 March 2023
Additional Information:
For the purpose of Open Access, the author has applied a Creative Commons Attribution (CC BY) license to any Author Accepted Manuscript version arising from this submission. MRC & NIHR funding.
Funding: This work was supported by grants from Medical Research Council (MRC) [MC_PC_21003; MC_PC_21001], British Heart Foundation, National Institute for Health and Care Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, NIHR Oxford Biomedical Research Centre, University of Oxford.
Identifiers
Local EPrints ID: 475715
URI: http://eprints.soton.ac.uk/id/eprint/475715
ISSN: 0021-972X
PURE UUID: a8d91ef2-9172-4c0d-88c4-9054c478c7ad
Catalogue record
Date deposited: 27 Mar 2023 16:30
Last modified: 01 Apr 2023 01:45
Export record
Altmetrics
Contributors
Author:
Rebecca J. Moon
Author:
Stefania D'Angelo
Author:
Christopher R. Holroyd
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics