Distribution and association of interpregnancy weight change with subsequent pregnancy outcomes in Asian women
Distribution and association of interpregnancy weight change with subsequent pregnancy outcomes in Asian women
The extent of interpregnancy weight change and its association with subsequent pregnancy outcomes among Asians remain unclear. We examined changes in maternal body mass index (BMI) between the first two deliveries and outcomes in the second delivery. Medical records of women with their first two consecutive deliveries between 2015 and 2020 at KK Women’s and Children’s Hospital, Singapore were retrieved. Gestational-age-adjusted BMI was determined by standardising to 12 weeks gestation and interpregnancy BMI change was calculated as the difference between both pregnancies. Pregnancy outcomes were analysed using modified Poisson regression models. Of 6264 included women with a median interpregnancy interval of 1.44 years, 40.7% had a stable BMI change within ± 1 kg/m2, 10.3% lost > 1 kg/m2, 34.3% gained 1–3 kg/m2 and 14.8% gained ≥ 3 kg/m2. Compared to women with stable BMI change, those with > 1 kg/m2 loss had higher risk of low birthweight (adjusted risk ratio [RR] 1.36; 95% confidence interval 1.02–1.80), while those with 1–3 kg/m2 gain had higher risks of large-for-gestational-age birth (1.16; 1.03–1.31), gestational diabetes (1.25; 1.06–1.49) and emergency Caesarean delivery (1.16; 1.03–1.31); these risks were higher in those with ≥ 3 kg/m2 gain. Our study strengthens the case for interpregnancy weight management to improve subsequent pregnancy outcomes.
Ku, Chee Wai
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Cheng, Tuck Seng
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Ku, Chee Onn
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Zhou, Kathy Xinzhou
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Cheung, Yin Bun
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Godfrey, Keith M.
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Han, Wee Meng
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Yap, Fabian
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Chan, Jerry Kok Yen
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Loy, See Ling
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24 March 2023
Ku, Chee Wai
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Cheng, Tuck Seng
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Ku, Chee Onn
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Zhou, Kathy Xinzhou
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Cheung, Yin Bun
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Godfrey, Keith M.
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Han, Wee Meng
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Yap, Fabian
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Chan, Jerry Kok Yen
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Loy, See Ling
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Ku, Chee Wai, Cheng, Tuck Seng, Ku, Chee Onn, Zhou, Kathy Xinzhou, Cheung, Yin Bun, Godfrey, Keith M., Han, Wee Meng, Yap, Fabian, Chan, Jerry Kok Yen and Loy, See Ling
(2023)
Distribution and association of interpregnancy weight change with subsequent pregnancy outcomes in Asian women.
Scientific Reports, 13 (1), [4834].
(doi:10.1038/s41598-023-31954-5).
Abstract
The extent of interpregnancy weight change and its association with subsequent pregnancy outcomes among Asians remain unclear. We examined changes in maternal body mass index (BMI) between the first two deliveries and outcomes in the second delivery. Medical records of women with their first two consecutive deliveries between 2015 and 2020 at KK Women’s and Children’s Hospital, Singapore were retrieved. Gestational-age-adjusted BMI was determined by standardising to 12 weeks gestation and interpregnancy BMI change was calculated as the difference between both pregnancies. Pregnancy outcomes were analysed using modified Poisson regression models. Of 6264 included women with a median interpregnancy interval of 1.44 years, 40.7% had a stable BMI change within ± 1 kg/m2, 10.3% lost > 1 kg/m2, 34.3% gained 1–3 kg/m2 and 14.8% gained ≥ 3 kg/m2. Compared to women with stable BMI change, those with > 1 kg/m2 loss had higher risk of low birthweight (adjusted risk ratio [RR] 1.36; 95% confidence interval 1.02–1.80), while those with 1–3 kg/m2 gain had higher risks of large-for-gestational-age birth (1.16; 1.03–1.31), gestational diabetes (1.25; 1.06–1.49) and emergency Caesarean delivery (1.16; 1.03–1.31); these risks were higher in those with ≥ 3 kg/m2 gain. Our study strengthens the case for interpregnancy weight management to improve subsequent pregnancy outcomes.
Text
Interpreg weight manuscript SR 6Mar23_clean
- Accepted Manuscript
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s41598-023-31954-5
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Accepted/In Press date: 20 March 2023
e-pub ahead of print date: 24 March 2023
Published date: 24 March 2023
Additional Information:
Funding Information:
K.M.G. has received reimbursement to speak at conferences sponsored by companies that sell nutritional products. K.M.G. is part of an academic consortium who has received research funding from Abbott, Nutrition, Nestle and Danone. C.W.K., T.S.C., C.O.K., K.X.Z., Y.B.C., W.M.H., F.Y., J.K.Y.C., and S.L.L declare that they have no competing interests.
Funding Information:
The authors would like to thank KK Women’s and Children’s Hospital for the institutional support received during this study, and Ms Nathalie Ang for data cleaning.
Funding Information:
This research was supported by the KKH Health Services Model of Care Transformation Fund (MoCTF) Grant (MoCTF/01/2020, MoCTF/02/2020 and MoCTF/03/2020) and the Lien Foundation Optimising Maternal and Child Health Programme Fund (Grant number not applicable). The funding body did not influence either the data collection and analysis or the writing and the decision to submit the manuscript. C.W.K. and J.K.Y.C. are supported by the National Medical Research Council, Ministry of Health, Singapore (NMRC/MOH-000596-00 and NMRC/CSA-SI-008-2016, respectively). K.M.G. is supported by the National Institute for Health Research (NIHR Senior Investigator (NF-SI-0515-10042), NIHR Southampton 1000DaysPlus Global Nutrition Research Group (17/63/154) and NIHR Southampton Biomedical Research Center (IS-BRC-1215-20004), British Heart Foundation (RG/15/17/3174) and the European Union (Erasmus + Programme ImpENSA 598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP). For the purpose of Open Access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission. T.S.C. is partially supported by the UK Medical Research Council (MC_UU_00006/2).
Publisher Copyright:
© 2023, The Author(s).
Identifiers
Local EPrints ID: 476029
URI: http://eprints.soton.ac.uk/id/eprint/476029
ISSN: 2045-2322
PURE UUID: 92f6b2b9-f45b-4a0f-abdb-45f731b9fa5b
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Date deposited: 04 Apr 2023 16:49
Last modified: 17 Mar 2024 02:38
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Contributors
Author:
Chee Wai Ku
Author:
Tuck Seng Cheng
Author:
Chee Onn Ku
Author:
Kathy Xinzhou Zhou
Author:
Yin Bun Cheung
Author:
Wee Meng Han
Author:
Fabian Yap
Author:
Jerry Kok Yen Chan
Author:
See Ling Loy
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