Modified T2 statistics for improved detection of aided cortical auditory evoked potentials in hearing-impaired infants
Modified T2 statistics for improved detection of aided cortical auditory evoked potentials in hearing-impaired infants
The cortical auditory evoked potential (CAEP) is a change in neural activity in response to sound, and is of interest for audiological assessment of infants, especially those who use hearing aids. Within this population, CAEP waveforms are known to vary substantially across individuals, which makes detecting the CAEP through visual inspection a challenging task. It also means that some of the best automated CAEP detection methods used in adults are probably not suitable for this population. This study therefore evaluates and optimizes the performance of new and existing methods for aided (i.e., the stimuli are presented through subjects’ hearing aid(s)) CAEP detection in infants with hearing loss. Methods include the conventional Hotellings T
2 test, various modified q-sample statistics, and two novel variants of T
2 statistics, which were designed to exploit the correlation structure underlying the data. Various additional methods from the literature were also evaluated, including the previously best-performing methods for adult CAEP detection. Data for the assessment consisted of aided CAEPs recorded from 59 infant hearing aid users with mild to profound bilateral hearing loss, and simulated signals. The highest test sensitivities were observed for the modified T
2 statistics, followed by the modified q-sample statistics, and lastly by the conventional Hotelling's T
2 test, which showed low detection rates for ensemble sizes <80 epochs. The high test sensitivities at small ensemble sizes observed for the modified T
2 and q-sample statistics are especially relevant for infant testing, as the time available for data collection tends to be limited in this population.
Hotelling's T test, aided CAEP detection, evoked potentials, hearing-impaired infants
Chesnaye, Michael
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Bell, Steven
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Harte, J.M.
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Simonsen, Lisbeth
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Visram, A.
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Stone, M.A.
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Munro, K.J.
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Simpson, David
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Chesnaye, Michael
5f337509-3255-4322-b1bf-d4d3836b36ec
Bell, Steven
91de0801-d2b7-44ba-8e8e-523e672aed8a
Harte, J.M.
20107083-3305-4997-8426-0372ff0b9954
Simonsen, Lisbeth
0f557be3-7c81-4604-ba2f-e7d852c9fd08
Visram, A.
fc4d761f-6800-4dfe-ade3-11e2a19cf347
Stone, M.A.
11600fb5-532b-4b5e-b07a-f96047dae057
Munro, K.J.
bcb0f186-5af1-433e-9ed1-a2ee77f46381
Simpson, David
53674880-f381-4cc9-8505-6a97eeac3c2a
Chesnaye, Michael, Bell, Steven, Harte, J.M., Simonsen, Lisbeth, Visram, A., Stone, M.A., Munro, K.J. and Simpson, David
(2023)
Modified T2 statistics for improved detection of aided cortical auditory evoked potentials in hearing-impaired infants.
Trends in Hearing, 27.
(doi:10.1177/23312165231154035).
Abstract
The cortical auditory evoked potential (CAEP) is a change in neural activity in response to sound, and is of interest for audiological assessment of infants, especially those who use hearing aids. Within this population, CAEP waveforms are known to vary substantially across individuals, which makes detecting the CAEP through visual inspection a challenging task. It also means that some of the best automated CAEP detection methods used in adults are probably not suitable for this population. This study therefore evaluates and optimizes the performance of new and existing methods for aided (i.e., the stimuli are presented through subjects’ hearing aid(s)) CAEP detection in infants with hearing loss. Methods include the conventional Hotellings T
2 test, various modified q-sample statistics, and two novel variants of T
2 statistics, which were designed to exploit the correlation structure underlying the data. Various additional methods from the literature were also evaluated, including the previously best-performing methods for adult CAEP detection. Data for the assessment consisted of aided CAEPs recorded from 59 infant hearing aid users with mild to profound bilateral hearing loss, and simulated signals. The highest test sensitivities were observed for the modified T
2 statistics, followed by the modified q-sample statistics, and lastly by the conventional Hotelling's T
2 test, which showed low detection rates for ensemble sizes <80 epochs. The high test sensitivities at small ensemble sizes observed for the modified T
2 and q-sample statistics are especially relevant for infant testing, as the time available for data collection tends to be limited in this population.
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Accepted/In Press date: 11 January 2023
e-pub ahead of print date: 27 February 2023
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Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This article presents independent research funded by the National Institute for Health Research (NIHR) under its Research for Patient Benefit (RfPB) Programme (Grant Reference Number PB-PG-0214-33009). K.J.M. and M.A.S. were supported by the NIHR Manchester Biomedial Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. This work was funded by the William Demant Foundation.
Publisher Copyright:
© The Author(s) 2023.
Keywords:
Hotelling's T test, aided CAEP detection, evoked potentials, hearing-impaired infants
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Local EPrints ID: 476810
URI: http://eprints.soton.ac.uk/id/eprint/476810
ISSN: 2331-2165
PURE UUID: 3dff4e7d-0a16-4084-b01a-cee750103046
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Date deposited: 16 May 2023 16:59
Last modified: 17 Mar 2024 02:56
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Author:
Michael Chesnaye
Author:
J.M. Harte
Author:
Lisbeth Simonsen
Author:
A. Visram
Author:
M.A. Stone
Author:
K.J. Munro
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