Drug delivery strategies for antibiofilm therapy
Drug delivery strategies for antibiofilm therapy
Although new antibiofilm agents have been developed to prevent and eliminate pathogenic biofilms, their widespread clinical use is hindered by poor biocompatibility and bioavailability, unspecific interactions and insufficient local concentrations. The development of innovative drug-delivery strategies can facilitate penetration of antimicrobials through biofilms, promote drug dispersal and synergistic bactericidal effects, and provide novel paradigms for clinical application. In this Review, we discuss the potential benefits of such emerging techniques for improving the clinical efficacy of antibiofilm agents, as well as highlighting the existing limitations and future prospects for these therapies in the clinic
antibiofilm therapy, drug delivery strategies
555-572
Choi, Victor
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Rohn, Jennifer L.
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Stoodley, Paul
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Carugo, Dario
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Stride, Eleanor
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September 2023
Choi, Victor
ce368a31-638e-4d1f-b9aa-a0f7d4ea185d
Rohn, Jennifer L.
b3cabf19-18c0-406a-8347-fb3759c7118b
Stoodley, Paul
08614665-92a9-4466-806e-20c6daeb483f
Carugo, Dario
0a4be6cd-e309-4ed8-a620-20256ce01179
Stride, Eleanor
c0143e95-81fa-47c8-b9bc-5b4fc319bba6
Choi, Victor, Rohn, Jennifer L., Stoodley, Paul, Carugo, Dario and Stride, Eleanor
(2023)
Drug delivery strategies for antibiofilm therapy.
Nature Reviews Microbiology, 21 (9), .
(doi:10.1038/s41579-023-00905-2).
Abstract
Although new antibiofilm agents have been developed to prevent and eliminate pathogenic biofilms, their widespread clinical use is hindered by poor biocompatibility and bioavailability, unspecific interactions and insufficient local concentrations. The development of innovative drug-delivery strategies can facilitate penetration of antimicrobials through biofilms, promote drug dispersal and synergistic bactericidal effects, and provide novel paradigms for clinical application. In this Review, we discuss the potential benefits of such emerging techniques for improving the clinical efficacy of antibiofilm agents, as well as highlighting the existing limitations and future prospects for these therapies in the clinic
Text
natrev delivery final
- Accepted Manuscript
More information
Accepted/In Press date: 28 April 2023
e-pub ahead of print date: 31 May 2023
Published date: September 2023
Additional Information:
Funding Information:
The authors acknowledge their funding sources: the Engineering and Physical Sciences Research Council (EP/V026623/1).
Publisher Copyright:
© 2023, Springer Nature Limited.
Keywords:
antibiofilm therapy, drug delivery strategies
Identifiers
Local EPrints ID: 477220
URI: http://eprints.soton.ac.uk/id/eprint/477220
ISSN: 1740-1526
PURE UUID: 60334e17-8f55-4c34-861e-d986023f493f
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Date deposited: 01 Jun 2023 16:46
Last modified: 05 Jun 2024 18:56
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Author:
Victor Choi
Author:
Jennifer L. Rohn
Author:
Eleanor Stride
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