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The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts

The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts
The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts

Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the role of inflammation in comorbid anxiety and depression in three asthma patient cohorts of the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project. Methods: U-BIOPRED was conducted by a European Union consortium of 16 academic institutions in 11 European countries. A subset dataset from subjects with valid anxiety and depression measures and a large blood biomarker dataset were analysed, including 198 non-smoking patients with severe asthma (SAn), 65 smoking patients with severe asthma (SAs), 61 non-smoking patients with mild-to-moderate asthma (MMA), and 20 healthy non-smokers (HC). The Hospital Anxiety and Depression Scale was used to measure anxiety and depression and a series of inflammatory markers were analysed by the SomaScan v3 platform (SomaLogic, Boulder, Colo). ANOVA and the Kruskal-Wallis test were used for multiple-group comparisons as appropriate. Results: There were significant group effects on anxiety and depression among the four cohort groups (p < 0.05). Anxiety and depression of SAn and SAs groups were significantly higher than that of MMA and HC groups (p < 0.05. There were significant differences in serum IL6, MCP1, CCL18, CCL17, IL8, and Eotaxin among the four groups (p < 0.05). Depression was significantly associated with IL6, MCP1, CCL18 level, and CCL17; whereas anxiety was associated with CCL17 only (p < 0.05). Conclusions: The current study suggests that severe asthma patients are associated with higher levels of anxiety and depression, and inflammatory responses may underlie this comorbid condition.

Anxiety, Asthma, Depression, Inflammation, U-BIOPRED
0889-1591
249–258
Hou, Ruihua
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Ye, Gang
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Cheng, Xiaojing
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Shaw, Dominick E.
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Bakke, Per S.
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Caruso, Massimo
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Dahlen, Barbro
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Dahlen, Sven Erik
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Fowler, Stephen J.
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Horváth, Ildikó
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Howarth, Peter H.
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Krug, Norbert
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Montuschi, Paolo
5f2586d1-3599-4f35-9a57-c0301fdc2ec4
Sanak, Marek
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Sandström, Thomas
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Auffray, Charles
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Meulder, Bertrand De
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Sousa, Ana R.
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Adcock, Ian M.
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Chung, Kian Fan
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Sterk, Peter J.
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Skipp, Paul
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Schofield, James Philip Robertso
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Djukanović, Ratko
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Hou, Ruihua
470bdcbc-93a9-4dad-aac5-26d455c34376
Ye, Gang
fc583a08-c1a8-45d1-a123-527378b71bc2
Cheng, Xiaojing
9a93d740-2d0f-42af-8e05-0608f7bb3461
Shaw, Dominick E.
83e98e0a-fd2d-4c44-9249-6ac3ebd9614f
Bakke, Per S.
14e4943c-16b0-4f9f-ab31-a72c6f02b581
Caruso, Massimo
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Dahlen, Barbro
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Dahlen, Sven Erik
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Fowler, Stephen J.
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Horváth, Ildikó
58e508ba-1b62-4ea5-a656-dda9498f90c7
Howarth, Peter H.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Krug, Norbert
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Montuschi, Paolo
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Sanak, Marek
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Sandström, Thomas
77a4c11d-a84f-4a52-9bfe-4ec83f62363a
Auffray, Charles
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Meulder, Bertrand De
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Sousa, Ana R.
66270f3e-43c9-4d6a-a82f-ae83f5b02944
Adcock, Ian M.
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Chung, Kian Fan
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Sterk, Peter J.
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Skipp, Paul
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Schofield, James Philip Robertso
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Djukanović, Ratko
654da06e-0d3c-405c-8d0c-24716b302fcd

Hou, Ruihua, Ye, Gang, Cheng, Xiaojing, Shaw, Dominick E., Bakke, Per S., Caruso, Massimo, Dahlen, Barbro, Dahlen, Sven Erik, Fowler, Stephen J., Horváth, Ildikó, Howarth, Peter H., Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Auffray, Charles, Meulder, Bertrand De, Sousa, Ana R., Adcock, Ian M., Chung, Kian Fan, Sterk, Peter J., Skipp, Paul, Schofield, James Philip Robertso and Djukanović, Ratko (2023) The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts. Brain, Behavior and Immunity, 111, 249–258. (doi:10.1016/j.bbi.2023.04.011).

Record type: Article

Abstract

Background: Growing evidence indicates high comorbid anxiety and depression in patients with asthma. However, the mechanisms underlying this comorbid condition remain unclear. The aim of this study was to investigate the role of inflammation in comorbid anxiety and depression in three asthma patient cohorts of the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project. Methods: U-BIOPRED was conducted by a European Union consortium of 16 academic institutions in 11 European countries. A subset dataset from subjects with valid anxiety and depression measures and a large blood biomarker dataset were analysed, including 198 non-smoking patients with severe asthma (SAn), 65 smoking patients with severe asthma (SAs), 61 non-smoking patients with mild-to-moderate asthma (MMA), and 20 healthy non-smokers (HC). The Hospital Anxiety and Depression Scale was used to measure anxiety and depression and a series of inflammatory markers were analysed by the SomaScan v3 platform (SomaLogic, Boulder, Colo). ANOVA and the Kruskal-Wallis test were used for multiple-group comparisons as appropriate. Results: There were significant group effects on anxiety and depression among the four cohort groups (p < 0.05). Anxiety and depression of SAn and SAs groups were significantly higher than that of MMA and HC groups (p < 0.05. There were significant differences in serum IL6, MCP1, CCL18, CCL17, IL8, and Eotaxin among the four groups (p < 0.05). Depression was significantly associated with IL6, MCP1, CCL18 level, and CCL17; whereas anxiety was associated with CCL17 only (p < 0.05). Conclusions: The current study suggests that severe asthma patients are associated with higher levels of anxiety and depression, and inflammatory responses may underlie this comorbid condition.

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Accepted/In Press date: 23 April 2023
e-pub ahead of print date: 3 May 2023
Published date: July 2023
Additional Information: Publisher Copyright: © 2023 The Author(s)
Keywords: Anxiety, Asthma, Depression, Inflammation, U-BIOPRED

Identifiers

Local EPrints ID: 477362
URI: http://eprints.soton.ac.uk/id/eprint/477362
ISSN: 0889-1591
PURE UUID: 7ab69cc3-5a05-434a-ab99-19ab2f67e6de
ORCID for Ruihua Hou: ORCID iD orcid.org/0000-0001-6127-1478
ORCID for Paul Skipp: ORCID iD orcid.org/0000-0002-2995-2959

Catalogue record

Date deposited: 05 Jun 2023 16:43
Last modified: 03 May 2024 01:40

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Contributors

Author: Ruihua Hou ORCID iD
Author: Gang Ye
Author: Xiaojing Cheng
Author: Dominick E. Shaw
Author: Per S. Bakke
Author: Massimo Caruso
Author: Barbro Dahlen
Author: Sven Erik Dahlen
Author: Stephen J. Fowler
Author: Ildikó Horváth
Author: Norbert Krug
Author: Paolo Montuschi
Author: Marek Sanak
Author: Thomas Sandström
Author: Charles Auffray
Author: Bertrand De Meulder
Author: Ana R. Sousa
Author: Ian M. Adcock
Author: Kian Fan Chung
Author: Peter J. Sterk
Author: Paul Skipp ORCID iD
Author: James Philip Robertso Schofield
Author: Ratko Djukanović

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