Determination of non-freezing water in different nonfouling materials by differential scanning calorimetry
Determination of non-freezing water in different nonfouling materials by differential scanning calorimetry
Nonfouling materials have attracted increasing interest for their excellent biocompatibility and low immunogenicity. Strong hydration is believed to be the key reason for their resisting capability to nonspecific protein adsorption. However, little attention has been paid to quantifying their strong water binding capacity. In this study, we synthesized four zwitterionic polymers, including poly(sulfobetaine methacrylate) (pSBMA), poly(carboxybetaine methacrylate) (pCBMA), poly(carboxybetaine acrylamide) (pCBAA) and poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC), and compared non-freezing water of these zwitterionic polymers with typical antifouling polymer poly(ethylene glycol) (PEG) using differential scanning calorimetry (DSC). Non-freezing water of their monomers was also investigated. The non-freezing water of the polymers (per unit) is pMPC (10.7 ± 1.4) ≈ pCBAA (10.8 ± 1.5) > pCBMA (9.0 ± 0.6) > pSBMA (6.6 ± 0.4) > PEG20000 (0.60 ± 0.04). Similar trend is observed for their monomers. For all studied zwitterionic materials, they showed higher binding capacity than PEG. We attribute the stronger hydration of zwitterionic polymers to their strong electrostatic interactions.
Non-freezing water, PEG, antifouling, zwitterionic
1012-1024
Ma, Guanglong
4ba2ed72-fcf8-4116-8548-6d4774a80934
Ji, Fangqin
8d4fc77d-58e8-4fa0-af95-6b3131d29a39
Lin, Weifeng
c2c2839e-c0dd-4522-a820-cdb677460f72
Chen, Shengfu
d75ea226-c200-4a3a-bc47-ddbfcbcfad76
3 February 2022
Ma, Guanglong
4ba2ed72-fcf8-4116-8548-6d4774a80934
Ji, Fangqin
8d4fc77d-58e8-4fa0-af95-6b3131d29a39
Lin, Weifeng
c2c2839e-c0dd-4522-a820-cdb677460f72
Chen, Shengfu
d75ea226-c200-4a3a-bc47-ddbfcbcfad76
Ma, Guanglong, Ji, Fangqin, Lin, Weifeng and Chen, Shengfu
(2022)
Determination of non-freezing water in different nonfouling materials by differential scanning calorimetry.
Journal of Biomaterials Science, Polymer Edition, 33 (8), .
(doi:10.1080/09205063.2022.2034285).
Abstract
Nonfouling materials have attracted increasing interest for their excellent biocompatibility and low immunogenicity. Strong hydration is believed to be the key reason for their resisting capability to nonspecific protein adsorption. However, little attention has been paid to quantifying their strong water binding capacity. In this study, we synthesized four zwitterionic polymers, including poly(sulfobetaine methacrylate) (pSBMA), poly(carboxybetaine methacrylate) (pCBMA), poly(carboxybetaine acrylamide) (pCBAA) and poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC), and compared non-freezing water of these zwitterionic polymers with typical antifouling polymer poly(ethylene glycol) (PEG) using differential scanning calorimetry (DSC). Non-freezing water of their monomers was also investigated. The non-freezing water of the polymers (per unit) is pMPC (10.7 ± 1.4) ≈ pCBAA (10.8 ± 1.5) > pCBMA (9.0 ± 0.6) > pSBMA (6.6 ± 0.4) > PEG20000 (0.60 ± 0.04). Similar trend is observed for their monomers. For all studied zwitterionic materials, they showed higher binding capacity than PEG. We attribute the stronger hydration of zwitterionic polymers to their strong electrostatic interactions.
Text
TBSP2034285-GM
- Accepted Manuscript
More information
Accepted/In Press date: 21 January 2022
e-pub ahead of print date: 24 January 2022
Published date: 3 February 2022
Additional Information:
Funding Information:
This research is supported by the National Natural Science Foundation of China (21975216, 21674092, and 21474085) and Natural Science Foundation of Zhejiang Province (LZ20B040001). We would like to thank Prof. J. Yuan from Nanjing Normal University for part of the DSC measurements.
Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
Keywords:
Non-freezing water, PEG, antifouling, zwitterionic
Identifiers
Local EPrints ID: 477409
URI: http://eprints.soton.ac.uk/id/eprint/477409
ISSN: 0920-5063
PURE UUID: 63614ef0-7237-460f-a783-f72577e13c73
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Date deposited: 06 Jun 2023 16:51
Last modified: 17 Mar 2024 07:13
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Author:
Guanglong Ma
Author:
Fangqin Ji
Author:
Weifeng Lin
Author:
Shengfu Chen
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