A patient's perspective on the side effects of tyrosine kinase inhibitors in the treatment of advanced and metastatic gastrointestinal stromal tumors

Aim: to provide the gastrointestinal stromal tumor patient's perspective on side effects of tyrosine kinase inhibitors and compare this with that of healthcare professionals.
Materials & methods: semi-structured interviews were conducted with 19 patients with an advanced or metastatic gastrointestinal stromal tumor, as well as six healthcare professionals, and five patients paricipated in a focus group. Thematic analysis was used to interpret the data.
Results: most participants (n = 29) reported gastrointestinal symptoms followed by tiredness (n = 25), edema (n = 22), muscle cramps (n = 21), skin problems (n = 21), eye problems (n = 11) and trouble sleeping (n = 10). Patients, but not healthcare professionals, reported cognitive problems or symptoms of depression.
Conclusion: these results underline the importance of including the patient's perspective, as there is a gap in symptom reporting between patients and healthcare professionals.

adverse events, gastrointestinal stromal tumors, interviews, patient-reported outcome, qualitative research, side effects, tyrosine kinase inhibitors

10.2217/fon-2022-0730

1479-6694

299 - 314

van de Wal, Deborah

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Venkatesh, Shreenila

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Benson, Charlotte

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Van Der Graaf, Winette T. A.

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Johnson, Colin D.

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Husson, Olga

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Sodergren, Samantha

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11 April 2023

van de Wal, Deborah

bab7f082-dbdc-4524-997a-60b8e1ec4da0

Venkatesh, Shreenila

45ce84f7-750e-4059-abae-c6cc8c11edf2

Benson, Charlotte

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Van Der Graaf, Winette T. A.

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Johnson, Colin D.

6aac1c24-a8f7-4e30-9aa6-2b2945e50464

Husson, Olga

37964f59-bb82-46c7-8f67-88c45ba50463

Sodergren, Samantha

d66fc3fa-2c98-403d-8ae5-410ef95de46e

van de Wal, Deborah, Venkatesh, Shreenila, Benson, Charlotte, Van Der Graaf, Winette T. A., Johnson, Colin D., Husson, Olga and Sodergren, Samantha (2023) A patient's perspective on the side effects of tyrosine kinase inhibitors in the treatment of advanced and metastatic gastrointestinal stromal tumors. Future Oncology, 19 (4), 299 - 314. (doi:10.2217/fon-2022-0730).

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Accepted/In Press date: 26 January 2023

Published date: 11 April 2023

Additional Information: Funding Information: The authors would like to thank the participants of this study and acknowledge the support received by GIST Cancer UK. The authors would also like to thank S Wheelwright for her assistance with moderation of the focus group. Financial & competing interests disclosure Funding Information: This study was supported by a grant from the European Organization for Research and Treatment of Cancer Quality of Life Group (010-2010). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. Publisher Copyright: © 2023 The Authors.

Keywords: adverse events, gastrointestinal stromal tumors, interviews, patient-reported outcome, qualitative research, side effects, tyrosine kinase inhibitors