Optical diffraction-based silicon sensors for the detection of DNA sequences
Optical diffraction-based silicon sensors for the detection of DNA sequences
This thesis describes the design, fabrication and characterisation of diffraction-based sensors on silicon (100) substrates for the detection of complementary DNA sequences using colloidal gold labels. In-depth analysis of variations of DNA sequence within the human genome and association with diseases is expected to lead to personalised medical treatment. There is a great need for DNA analysis technologies and for techniques to determine whether sequence variations occur on the same chromosomal strand with applications in disease screening and diagnosis. Novel two-dimensional diffraction structures are designed and fabricated. It is shown that two-dimensional diffraction approaches may potentially offer multiplexing of DNA detection assays.
Weld, Andrew Mark
6cb1b99f-64b4-4f86-9fc7-b1283d45e699
29 June 2007
Weld, Andrew Mark
6cb1b99f-64b4-4f86-9fc7-b1283d45e699
Weld, Andrew Mark
(2007)
Optical diffraction-based silicon sensors for the detection of DNA sequences.
University of Southampton, Optoelectronic Research Centre, Doctoral Thesis, 249pp.
Record type:
Thesis
(Doctoral)
Abstract
This thesis describes the design, fabrication and characterisation of diffraction-based sensors on silicon (100) substrates for the detection of complementary DNA sequences using colloidal gold labels. In-depth analysis of variations of DNA sequence within the human genome and association with diseases is expected to lead to personalised medical treatment. There is a great need for DNA analysis technologies and for techniques to determine whether sequence variations occur on the same chromosomal strand with applications in disease screening and diagnosis. Novel two-dimensional diffraction structures are designed and fabricated. It is shown that two-dimensional diffraction approaches may potentially offer multiplexing of DNA detection assays.
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Weld_2007_thesis_3858.pdf
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Published date: 29 June 2007
Organisations:
University of Southampton
Identifiers
Local EPrints ID: 47762
URI: http://eprints.soton.ac.uk/id/eprint/47762
PURE UUID: a386888a-0cb0-4590-a8a5-1b77bfdaae61
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Date deposited: 15 Aug 2007
Last modified: 15 Mar 2024 09:36
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Author:
Andrew Mark Weld
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